Protein Alignment Cul6 and CUL3B

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_177125.3
• Gene: CUL3B / 843303
• AraportID: AT1G69670
• Length: 732
• Species: Arabidopsis thaliana
• Alignment Length: 768
• Identity: 153/768 - (19%)
• Similarity: 301/768 - (39%)
• Gaps: 205/768 - (26%)

  Fly    40 LMHLYHLIYKQCAA-------ERN-WNNPAQKNGRSLYIVLSDCLMKRLKNIAWVMENQL----- 91
            |.|..|.||...|:       .|| :|....|.|..||..|...:...||.|...:|...
plant    32 LEHAIHEIYNHNASGLSFEELYRNAYNMVLHKYGDKLYTGLVTTMTFHLKEICKSIEEAQGGAFL 96

  Fly    92 --------DDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAM 148
                    |.||.:::|...|                      .:::|..:...|:|: ::.|.:
plant    97 ELLNRKWNDHNKALQMIRDIL----------------------MYMDRTYVSTTKKTH-VHELGL 138

  Fly   149 ISWKELVFEPSVTILAAIRLILSQMPREYNKSLEYQVYQVLQSIVELY---ANDKYQDVSLPSRI 210
            ..|::.|...|......:..:|..:.:|....:..:|  :::::::::   ....|||     ..
plant   139 HLWRDNVVYSSKIQTRLLNTLLDLVHKERTGEVIDRV--LMRNVIKMFMDLGESVYQD-----DF 196

  Fly   211 DKIFTEKVMDFYKSTTLHEFQKIVVSNDY---------KDFKHFLRYACLAMPEIENGTQFKAIL 266
            :|.|.|...:|||..:: ||.:.....:|         ::.:..:.|.     :.::..:..:::
plant   197 EKPFLEASAEFYKVESM-EFIESCDCGEYLKKAEKPLVEEVERVVNYL-----DAKSEAKITSVV 255

  Fly   267 KRYLAARLQETRLSGKDYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEINRKGQIIDPTRLL 331
            :|.:.|          :::|..:             |.:.:.:|:.:..::....|::..   |.
plant   256 EREMIA----------NHVQRLV-------------HMENSGLVNMLLNDKYEDMGRMYS---LF 294

  Fly   332 VTYANELMTKRQESEEAIIDELKRIVKCVEFLSDEYKFI-------DMYLKALRIRQINETSTSD 389
            ...||.|:|.|......:.:..|::|...|...|..:|:       |.|.:.:.:...|:.:..:
plant   295 RRVANGLVTVRDVMTLHLREMGKQLVTDPEKSKDPVEFVQRLLDERDKYDRIINMAFNNDKTFQN 359

  Fly   390 GVESIM--YSLLNKKMANFVTRCIYVQLR---------DV----DKLRTL----------KKEFQ 429
            .:.|..  :..||.:...|::..:..:||         ||    ||:..|          :|.::
plant   360 ALNSSFEYFVNLNTRSPEFISLFVDDKLRKGLKGVGEEDVDLILDKVMMLFRYLQEKDVFEKYYK 424

  Fly   430 DHLNSK---G------------IKL----GFDFRPKCFKNDGSFENFNLT--------------- 460
            .||..:   |            :||    |:.|..|.   :|.|.:...:
plant   425 QHLAKRLLSGKTVSDDAERNLIVKLKTECGYQFTSKL---EGMFTDMKTSHDTLLGFYNSHPELS 486

  Fly   461 ------------------------LPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEITCH 501
                                    ||.|:....::||.:|.......:...|.|  :.:.:|...
plant   487 EGPTLVVQVLTTGSWPTQPTIQCNLPAEVSVLCEKFRSYYLGTHTGRRLSWQTN--MGTADIKAV 549

  Fly   502 LNQ-SVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI----------KFLV 555
            ..: ..:.|.|||.||.||||||..:|.:.:|:..|..:....|:..|:.:          |..:
plant   550 FGKGQKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPTPDLKRCLQSMACVKGKNVLRKEPM 614

  Fly   556 YIEVNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKIRRDK--QVDAAIVRIMKGQ 618
            ..|:.:.::..:|..|.::..::.....:.:|..: .||.|...::..|:  |::||||||||.:
plant   615 SKEIAEEDWFVVNDRFASKFYKVKIGTVVAQKETE-PEKQETRQRVEEDRKPQIEAAIVRIMKSR 678

  Fly   619 KQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERDNY-YNIYRYL 670
            :.|:::.:|:.|.::|:.|.....:.||||::.|:||::|||||. ..:||||
plant   679 RVLDHNNIIAEVTKQLQTRFLANPTEIKKRIESLIERDFLERDNTDRKLYRYL 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	151/766 (20%)
CUL3B	NP_177125.3	Cullin	29..630	CDD:459983	117/664 (18%)
		Cullin_Nedd8	662..724	CDD:463146	27/61 (44%)