DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and CUL3B

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001319357.1	Gene:	CUL3B / 843303	AraportID:	AT1G69670	Length:	732	Species:	Arabidopsis thaliana

Alignment Length:	768	Identity:	153/768 - (19%)
Similarity:	301/768 - (39%)	Gaps:	205/768 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LMHLYHLIYKQCAA-------ERN-WNNPAQKNGRSLYIVLSDCLMKRLKNIAWVMENQL----- 91
            |.|..|.||...|:       .|| :|....|.|..||..|...:...||.|...:|...
plant    32 LEHAIHEIYNHNASGLSFEELYRNAYNMVLHKYGDKLYTGLVTTMTFHLKEICKSIEEAQGGAFL 96

  Fly    92 --------DDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAM 148
                    |.||.:::|...|                      .:::|..:...|:|: ::.|.:
plant    97 ELLNRKWNDHNKALQMIRDIL----------------------MYMDRTYVSTTKKTH-VHELGL 138

  Fly   149 ISWKELVFEPSVTILAAIRLILSQMPREYNKSLEYQVYQVLQSIVELY---ANDKYQDVSLPSRI 210
            ..|::.|...|......:..:|..:.:|....:..:|  :::::::::   ....|||     ..
plant   139 HLWRDNVVYSSKIQTRLLNTLLDLVHKERTGEVIDRV--LMRNVIKMFMDLGESVYQD-----DF 196

  Fly   211 DKIFTEKVMDFYKSTTLHEFQKIVVSNDY---------KDFKHFLRYACLAMPEIENGTQFKAIL 266
            :|.|.|...:|||..:: ||.:.....:|         ::.:..:.|.     :.::..:..:::
plant   197 EKPFLEASAEFYKVESM-EFIESCDCGEYLKKAEKPLVEEVERVVNYL-----DAKSEAKITSVV 255

  Fly   267 KRYLAARLQETRLSGKDYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEINRKGQIIDPTRLL 331
            :|.:.|          :::|..:             |.:.:.:|:.:..::....|::..   |.
plant   256 EREMIA----------NHVQRLV-------------HMENSGLVNMLLNDKYEDMGRMYS---LF 294

  Fly   332 VTYANELMTKRQESEEAIIDELKRIVKCVEFLSDEYKFI-------DMYLKALRIRQINETSTSD 389
            ...||.|:|.|......:.:..|::|...|...|..:|:       |.|.:.:.:...|:.:..:
plant   295 RRVANGLVTVRDVMTLHLREMGKQLVTDPEKSKDPVEFVQRLLDERDKYDRIINMAFNNDKTFQN 359

  Fly   390 GVESIM--YSLLNKKMANFVTRCIYVQLR---------DV----DKLRTL----------KKEFQ 429
            .:.|..  :..||.:...|::..:..:||         ||    ||:..|          :|.::
plant   360 ALNSSFEYFVNLNTRSPEFISLFVDDKLRKGLKGVGEEDVDLILDKVMMLFRYLQEKDVFEKYYK 424

  Fly   430 DHLNSK---G------------IKL----GFDFRPKCFKNDGSFENFNLT--------------- 460
            .||..:   |            :||    |:.|..|.   :|.|.:...:
plant   425 QHLAKRLLSGKTVSDDAERNLIVKLKTECGYQFTSKL---EGMFTDMKTSHDTLLGFYNSHPELS 486

  Fly   461 ------------------------LPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEITCH 501
                                    ||.|:....::||.:|.......:...|.|  :.:.:|...
plant   487 EGPTLVVQVLTTGSWPTQPTIQCNLPAEVSVLCEKFRSYYLGTHTGRRLSWQTN--MGTADIKAV 549

  Fly   502 LNQ-SVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI----------KFLV 555
            ..: ..:.|.|||.||.||||||..:|.:.:|:..|..:....|:..|:.:          |..:
plant   550 FGKGQKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPTPDLKRCLQSMACVKGKNVLRKEPM 614

  Fly   556 YIEVNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKIRRDK--QVDAAIVRIMKGQ 618
            ..|:.:.::..:|..|.::..::.....:.:|..: .||.|...::..|:  |::||||||||.:
plant   615 SKEIAEEDWFVVNDRFASKFYKVKIGTVVAQKETE-PEKQETRQRVEEDRKPQIEAAIVRIMKSR 678

  Fly   619 KQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERDNY-YNIYRYL 670
            :.|:::.:|:.|.::|:.|.....:.||||::.|:||::|||||. ..:||||
plant   679 RVLDHNNIIAEVTKQLQTRFLANPTEIKKRIESLIERDFLERDNTDRKLYRYL 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	151/766 (20%)
		CULLIN	362..500	CDD:214545	36/227 (16%)
		Cullin_Nedd8	606..661	CDD:287520	23/54 (43%)
CUL3B	NP_001319357.1	Cullin	29..630	CDD:366357	117/664 (18%)
CUL3B	NP_001319357.1	Cullin_Nedd8	659..726	CDD:214883	27/66 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820