DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and CUL2

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001318910.1	Gene:	CUL2 / 839415	AraportID:	AT1G02980	Length:	742	Species:	Arabidopsis thaliana

Alignment Length:	791	Identity:	179/791 - (22%)
Similarity:	321/791 - (40%)	Gaps:	213/791 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAER-----------------NWNN----PAQKNG 65
            ||.:.:...|...||..:.|.||..::..|..:.                 ::|.    ||.:..
plant    22 LQKILEEVPDEPPFDPVQRMQLYTTVHNLCTQKPPNDYSQQIYDRYGGVYVDYNKQTVLPAIREK 86

  Fly    66 RSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVE 130
            ...|::..  |:||     |.  ||       :::.::|.|:..|             .:|.:..
plant    87 HGEYMLRE--LVKR-----WA--NQ-------KILVRWLSHFFEY-------------LDRFYTR 122

  Fly   131 RERLKGDKETYPIYRLAMISWKELVFEPSVTILAAIRLILSQMPRE---YNKSLEYQVYQVLQSI 192
            |    |...|  :..:..||:::||::...:......|.|....||   .:::|       |:::
plant   123 R----GSHPT--LSAVGFISFRDLVYQELQSKAKDAVLALIHKEREGEQIDRAL-------LKNV 174

  Fly   193 VELYAND------KY------------------------QDVSLPS---------RIDKIFTEKV 218
            :::|..:      ||                        |:.|.|.         |::|   |:|
plant   175 IDVYCGNGMGELVKYEEDFESFLLEDSASYYSRNASRWNQENSCPDYMIKAEESLRLEK---ERV 236

  Fly   219 MDFYKSTT------------LHEFQKIVVSNDYKDFKHFLR----------YACLAMPEIENGTQ 261
            .::..|||            |....|.::.|::...:..||          |. |..| |..|..
plant   237 TNYLHSTTEPKLVAKVQNELLVVVAKQLIENEHSGCRALLRDDKMDDLARMYR-LYHP-IPQGLD 299

  Fly   262 -----FK--------AILKRYL-AARLQETRLSG---------------KDYIQAFLGLCRGPLQ 297
                 ||        |::|:.. ||..:....||               .|....::..|   .|
plant   300 PVADLFKQHITVEGSALIKQATEAATDKAASTSGLKVQDQVLIRQLIDLHDKFMVYVDEC---FQ 361

  Fly   298 RALRDHTKLAEVVDAVCKEEINRKGQIIDPTRLLVTYANELM-----TKRQESEEAIIDELKRIV 357
            :....|..|.|..:..|    |:....:....:|.||.:.::     .::.|:|:..: .|:::|
plant   362 KHSLFHKALKEAFEVFC----NKTVAGVSSAEILATYCDNILKTGGGIEKLENEDLEL-TLEKVV 421

  Fly   358 KCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLR 422
            |.:.::||:..|.:.:.|....|.:.:.:.:|..|..:.:...:.:....|..:...|.|:
plant   422 KLLVYISDKDLFAEFFRKKQARRLLFDRNGNDYHERSLLTKFKELLGAQFTSKMEGMLTDM---- 482

  Fly   423 TLKKEFQDHL-----NSKGIKLGFDFRPKCFKND--GSFENFNLTLPDELQQAWKEFRIFYEARK 480
            ||.||.|.:.     .:|..|||.||........  .|::..:|.||.|:....:.|:.:| ..|
plant   483 TLAKEHQTNFVEFLSVNKTKKLGMDFTVTVLTTGFWPSYKTTDLNLPIEMVNCVEAFKAYY-GTK 546

  Fly   481 LQSKAIIQLNNELSSGEITCHL----NQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGV-- 539
            ..|:   :|:...|.|  ||.|    ::....:.|:|.|.|||:|||..||.:..|::..|.:
plant   547 TNSR---RLSWIYSLG--TCQLAGKFDKKTIEIVVTTYQAAVLLLFNNTERLSYTEILEQLNLGH 606

  Fly   540 -ELETLQEALKQIKFLVYIE------VNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEI 597
             :|..|..:|..:|:.:.|:      ::..:..|.|..||::.||:  ..|||    .::|:.:|
plant   607 EDLARLLHSLSCLKYKILIKEPMSRNISNTDTFEFNSKFTDKMRRI--RVPLP----PMDERKKI 665

  Fly   598 ELKIRRDKQ--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLER 660
            ...:.:|::  :|||:|||||.:|.|.:.:|:|...|.|....||.:..||||::.|:.|:||||
plant   666 VEDVDKDRRYAIDAALVRIMKSRKVLGHQQLVSECVEHLSKMFKPDIKMIKKRIEDLISRDYLER 730

  Fly   661 D-NYYNIYRYL 670
            | :..|.::||
plant   731 DTDNPNTFKYL 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	175/786 (22%)
		CULLIN	362..500	CDD:214545	33/144 (23%)
		Cullin_Nedd8	606..661	CDD:287520	25/56 (45%)
CUL2	NP_001318910.1	Cullin	12..645	CDD:366357	139/687 (20%)
CUL2	NP_001318910.1	Cullin_Nedd8	669..736	CDD:214883	28/66 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820