Protein Alignment Cul6 and CUL2

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_171797.2
• Gene: CUL2 / 839415
• AraportID: AT1G02980
• Length: 742
• Species: Arabidopsis thaliana
• Alignment Length: 791
• Identity: 179/791 - (22%)
• Similarity: 321/791 - (40%)
• Gaps: 213/791 - (26%)

  Fly    22 LQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAER-----------------NWNN----PAQKNG 65
            ||.:.:...|...||..:.|.||..::..|..:.                 ::|.    ||.:..
plant    22 LQKILEEVPDEPPFDPVQRMQLYTTVHNLCTQKPPNDYSQQIYDRYGGVYVDYNKQTVLPAIREK 86

  Fly    66 RSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVE 130
            ...|::..  |:||     |.  ||       :::.::|.|:..|             .:|.:..
plant    87 HGEYMLRE--LVKR-----WA--NQ-------KILVRWLSHFFEY-------------LDRFYTR 122

  Fly   131 RERLKGDKETYPIYRLAMISWKELVFEPSVTILAAIRLILSQMPRE---YNKSLEYQVYQVLQSI 192
            |    |...|  :..:..||:::||::...:......|.|....||   .:::|       |:::
plant   123 R----GSHPT--LSAVGFISFRDLVYQELQSKAKDAVLALIHKEREGEQIDRAL-------LKNV 174

  Fly   193 VELYAND------KY------------------------QDVSLPS---------RIDKIFTEKV 218
            :::|..:      ||                        |:.|.|.         |::|   |:|
plant   175 IDVYCGNGMGELVKYEEDFESFLLEDSASYYSRNASRWNQENSCPDYMIKAEESLRLEK---ERV 236

  Fly   219 MDFYKSTT------------LHEFQKIVVSNDYKDFKHFLR----------YACLAMPEIENGTQ 261
            .::..|||            |....|.::.|::...:..||          |. |..| |..|..
plant   237 TNYLHSTTEPKLVAKVQNELLVVVAKQLIENEHSGCRALLRDDKMDDLARMYR-LYHP-IPQGLD 299

  Fly   262 -----FK--------AILKRYL-AARLQETRLSG---------------KDYIQAFLGLCRGPLQ 297
                 ||        |::|:.. ||..:....||               .|....::..|   .|
plant   300 PVADLFKQHITVEGSALIKQATEAATDKAASTSGLKVQDQVLIRQLIDLHDKFMVYVDEC---FQ 361

  Fly   298 RALRDHTKLAEVVDAVCKEEINRKGQIIDPTRLLVTYANELM-----TKRQESEEAIIDELKRIV 357
            :....|..|.|..:..|    |:....:....:|.||.:.::     .::.|:|:..: .|:::|
plant   362 KHSLFHKALKEAFEVFC----NKTVAGVSSAEILATYCDNILKTGGGIEKLENEDLEL-TLEKVV 421

  Fly   358 KCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLR 422
            |.:.::||:..|.:.:.|....|.:.:.:.:|..|..:.:...:.:....|..:...|.|:
plant   422 KLLVYISDKDLFAEFFRKKQARRLLFDRNGNDYHERSLLTKFKELLGAQFTSKMEGMLTDM---- 482

  Fly   423 TLKKEFQDHL-----NSKGIKLGFDFRPKCFKND--GSFENFNLTLPDELQQAWKEFRIFYEARK 480
            ||.||.|.:.     .:|..|||.||........  .|::..:|.||.|:....:.|:.:| ..|
plant   483 TLAKEHQTNFVEFLSVNKTKKLGMDFTVTVLTTGFWPSYKTTDLNLPIEMVNCVEAFKAYY-GTK 546

  Fly   481 LQSKAIIQLNNELSSGEITCHL----NQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGV-- 539
            ..|:   :|:...|.|  ||.|    ::....:.|:|.|.|||:|||..||.:..|::..|.:
plant   547 TNSR---RLSWIYSLG--TCQLAGKFDKKTIEIVVTTYQAAVLLLFNNTERLSYTEILEQLNLGH 606

  Fly   540 -ELETLQEALKQIKFLVYIE------VNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEI 597
             :|..|..:|..:|:.:.|:      ::..:..|.|..||::.||:  ..|||    .::|:.:|
plant   607 EDLARLLHSLSCLKYKILIKEPMSRNISNTDTFEFNSKFTDKMRRI--RVPLP----PMDERKKI 665

  Fly   598 ELKIRRDKQ--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLER 660
            ...:.:|::  :|||:|||||.:|.|.:.:|:|...|.|....||.:..||||::.|:.|:||||
plant   666 VEDVDKDRRYAIDAALVRIMKSRKVLGHQQLVSECVEHLSKMFKPDIKMIKKRIEDLISRDYLER 730

  Fly   661 D-NYYNIYRYL 670
            | :..|.::||
plant   731 DTDNPNTFKYL 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	175/786 (22%)
CUL2	NP_171797.2	Cullin	12..645	CDD:459983	139/687 (20%)
		RMtype1_S_TRD-CR_like	<641..689	CDD:365779	19/53 (36%)
		Cullin_Nedd8	672..734	CDD:463146	28/61 (46%)