Protein Alignment Cul6 and CUL4

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_568658.1
• Gene: CUL4 / 834663
• AraportID: AT5G46210
• Length: 792
• Species: Arabidopsis thaliana
• Alignment Length: 658
• Identity: 140/658 - (21%)
• Similarity: 224/658 - (34%)
• Gaps: 234/658 - (35%)

  Fly    72 GNVTEIDLS--RRGLSGNFPFDSVCEIQSLEKLSLG----FNSLSGIIPSDLKNCTSLKYLDLGN 130
            ||..|.||:  ::|:.....|.|    |...|:|||    |..|     .|:|.  .|:.::...
plant   646 GNAFEKDLAAGQQGVGRKHSFSS----QLQNKVSLGSPRLFQEL-----QDVKR--DLEVVEQIT 699

  Fly   131 NLFSGAFPEFSSLNQ---------LQFLY---------LNNSAFSGVFPWKSLRNA--TSLVVLS 175
            .|.|.....:.:||.         ||.|.         .|........|.|:.::.  .|.:|:.
plant   700 QLISTLHGTYQNLNMTVAQDWCLGLQRLVRLKEEEIQSANKCHLQLQLPRKADKSGRPMSFMVVF 764

  Fly   176 LGDNPFDATADFPVEVVSLKKLSW---LYLSNCSIAGKIPPAIGDLTELRNLEIS----DSGLTG 233
            :..||             |.|:||   |:|:..::..:..|  |.|......::.    ...|..
plant   765 ITPNP-------------LSKISWVNRLHLAKIALREENQP--GWLCPEEEKKVKAPFWSPTLVC 814

  Fly   234 EIPSEISKLTNLWQLELYNNSLTGKLPTGFGNLKNLTYLDASTNLLQGDL------------SEL 286
            .:|:..:|..:|        .|.|.:.|...| ..|.:...||:|.||.|            .::
plant   815 RLPAFSTKAADL--------QLGGAVHTPVQN-SLLGFSSVSTSLPQGYLWVGGGQVGGAGHIQI 870

  Fly   287 RSLTNLVSLQMFE---------------------NEFSGEIPLEFGEFKDLV-------NLSLYT 323
            .|| |..|.:|.:                     |:...|.....|..:..|       ::.:|.
plant   871 FSL-NHTSPRMLKAFPLPSCVLCVENVCPRAPEGNDERDEEESAAGSARPAVCVGLQDGSIMVYG 934

  Fly   324 NKLTGS-----------------------LPQGL--GSLADFDFIDASENLLTGPIPPDMCK--N 361
            |..||:                       |..||  ||:|   ...|::..|..|..|.:.|  :
plant   935 NVDTGTPCLMAVGSPGVQPVKCLRHSPSFLCAGLQDGSVA---LYPATQGGLWDPGSPLVVKVGD 996

  Fly   362 GKMKALLLLQNNLTGSIPESYANCLTLQRFRVSENNLNGTVPAGLWGLPKLEIIDIEMNNFEG-- 424
            |.::|||::.    |.:   :|:|    |.||       ||         ||...::...||.
plant   997 GPVQALLVID----GCV---WASC----RNRV-------TV---------LEPGTLKTQTFEAVQ 1034

  Fly   425 ----PITADIKNGKMLGALYLGFNKLSD---------ELPEEIG-DTESLTKVELNNNRFTGK-- 473
                .||..:::|   |.:::.|:..|.         ||.:||. .|.::......|.|.|..
plant  1035 DEGISITHMVRSG---GGVWMAFSGGSSIRLFHTETLELLQEINIATRTMLLPGQKNPRITALLI 1096

  Fly   474 ------IPSSIG--------KLKGLSSL----KMQSNGFSGEIPDSIGSCSMLSDVNMAQNSISG 520
                  :.:.:|        ||:|:..:    .:..||..|.:.....:||.::...:..:..||
plant  1097 CQGLLWVGTDLGILVTLPVPKLEGIPKITGKGMVSLNGHCGPVQFLTLACSSIAPDELRTDQGSG 1161

  Fly   521 E-IPHTLG------------SLPTLNALNLSDNKLSGRIPESLSSLRLSLLDLSNNRLSGRIP-L 571
            | |..:.|            .||       |||....|:...|...||        |.:..:| |
plant  1162 EDISQSDGPAEPKEDTPDGPDLP-------SDNAPPSRLKGILLQYRL--------RGTSHLPGL 1211

  Fly   572 SLSSYNGS 579
            .||:..||
plant  1212 HLSAREGS 1219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	140/658 (21%)
CUL4	NP_568658.1	Cullin	96..693	CDD:459983	17/57 (30%)
		Cullin_Nedd8	724..784	CDD:463146	16/72 (22%)