Protein Alignment Cul6 and CUL1

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_567243.1
• Gene: CUL1 / 825648
• AraportID: AT4G02570
• Length: 738
• Species: Arabidopsis thaliana
• Alignment Length: 775
• Identity: 184/775 - (23%)
• Similarity: 321/775 - (41%)
• Gaps: 163/775 - (21%)

  Fly     9 NYFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLS 73
            :|..:.:..:..||:.:|:     .:||.::.|.||..||..|.     ..|.....:.||....
plant    13 DYMQTGITKLKRILEGLNE-----PAFDSEQYMMLYTTIYNMCT-----QKPPHDYSQQLYDKYR 67

  Fly    74 DCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDK 138
            :...:.:.:.......:..|...:|.:.|   .|..::.....|:...|:.:|.::.|..|.
plant    68 EAFEEYINSTVLPALREKHDEFMLRELFK---RWSNHKVMVRWLSRFFYYLDRYFIARRSLP--- 126

  Fly   139 ETYPIYRLAMISWKELVFEP--SVTILAAIRLI-------------------------LSQMPRE 176
               |:..:.:..:::||:..  |....|.|.|:                         :.||.|
plant   127 ---PLNEVGLTCFRDLVYNELHSKVKQAVIALVDKEREGEQIDRALLKNVLDIYVEIGMGQMER- 187

  Fly   177 YNKSLEYQVYQVLQSIVELYANDKYQDVSLPSRIDKI------FTEKVMDFYKSTT--------L 227
            |.:..|..:.|...|.....|:...|:.|.|..:.|.      ..|:|..:..|::        .
plant   188 YEEDFESFMLQDTSSYYSRKASSWIQEDSCPDYMLKSEECLKKERERVAHYLHSSSEPKLVEKVQ 252

  Fly   228 HEFQKIVVSNDYKDFKHFLRYACLAM----------------PEIENGTQFKA-ILKRYLAAR-- 273
            ||. .:|.::...:.:|   ..|.|:                .:|..|.:..| |.|:::.|.
plant   253 HEL-LVVFASQLLEKEH---SGCRALLRDDKVDDLSRMYRLYHKILRGLEPVANIFKQHVTAEGN 313

  Fly   274 -------------------LQETRLSGK-----DYIQAFLGLCRGPLQRALRDHTKLAEVVDAVC 314
                               :||..|..|     |....::..|   .|.....|..|.|..:..|
plant   314 ALVQQAEDTATNQVANTASVQEQVLIRKVIELHDKYMVYVTEC---FQNHTLFHKALKEAFEIFC 375

  Fly   315 KEEINRKGQIIDPTRLLVTYANELMTK---RQESEEAIIDELKRIVKCVEFLSDEYKFIDMYLKA 376
            .:.:.....    ..||.|:.:.::.|   .:.|:|||.|.|:::||.:.::||:..|.:.|.|.
plant   376 NKTVAGSSS----AELLATFCDNILKKGGSEKLSDEAIEDTLEKVVKLLAYISDKDLFAEFYRKK 436

  Fly   377 LRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSK-----G 436
            |..|.:.:.|.:|..|..:.:.|.::.....|..:...:.|:...|..:..|:|:|.|.     |
plant   437 LARRLLFDRSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLARENQNSFEDYLGSNPAANPG 501

  Fly   437 IKLGF-----DFRPKCFKNDGSFENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSG 496
            |.|..     .|.|       |:::|::.||.|:.:..:.|:.|||.:....|    |....|.|
plant   502 IDLTVTVLTTGFWP-------SYKSFDINLPSEMIKCVEVFKGFYETKTKHRK----LTWIYSLG 555

  Fly   497 EITCHLN----QSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI---KFL 554
              |||:|    |....|.|||.|.|||:|||..::.:..|::..|.:..|.|...|..:   |:.
plant   556 --TCHINGKFDQKAIELIVSTYQAAVLLLFNTTDKLSYTEILAQLNLSHEDLVRLLHSLSCAKYK 618

  Fly   555 VYIE------VNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKIRRDKQ--VDAAI 611
            :.::      |::.:..|.|..||:|.||:  ..|||    .::|:.::...:.:|::  :||||
plant   619 ILLKEPNTKTVSQNDAFEFNSKFTDRMRRI--KIPLP----PVDERKKVVEDVDKDRRYAIDAAI 677

  Fly   612 VRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERDNYY-NIYRYL 670
            |||||.:|.|.:.:|:|...|:|....||.:..||||::.|:.|:|||||... |::|||
plant   678 VRIMKSRKVLGHQQLVSECVEQLSRMFKPDIKAIKKRMEDLITRDYLERDKENPNMFRYL 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	179/757 (24%)
CUL1	NP_567243.1	Cullin	12..641	CDD:459983	142/671 (21%)
		Cullin_Nedd8	668..730	CDD:463146	29/61 (48%)