DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and CUL5

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_003469.2	Gene:	CUL5 / 8065	HGNCID:	2556	Length:	780	Species:	Homo sapiens

Alignment Length:	811	Identity:	175/811 - (21%)
Similarity:	326/811 - (40%)	Gaps:	201/811 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDC 75
            :|.|.|:   :|:::.|     .|...|:...|:..::..|.    |::   |....::..|.:.
Human    19 WDFMRPI---VLKLLRQ-----ESVTKQQWFDLFSDVHAVCL----WDD---KGPAKIHQALKED 68

  Fly    76 LMKRLKNI-AWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERE--RLKGD 137
            :::.:|.. |.|:.:| ||.   .|:..|:..|..:...|:.|...........:.::  ..|.:
Human    69 ILEFIKQAQARVLSHQ-DDT---ALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSN 129

  Fly   138 KETYPIYRLAMISWKELVFEPSVTIL--AAIRLI-LSQMPREYNKSLEYQVYQVLQSIVELYAN- 198
            .|...:.:|.:.:|.|.:|......|  :|::|: ..::...::..|   |..|.:|.|.|.:|
Human   130 VEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQL---VIGVRESYVNLCSNP 191

  Fly   199 -DK---YQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMPEIENG 259
             ||   |:|     ..:|.:.:....||::......|:..|.|       :::||...:.|.|.
Human   192 EDKLQIYRD-----NFEKAYLDSTERFYRTQAPSYLQQNGVQN-------YMKYADAKLKEEEK- 243

  Fly   260 TQFKAILKRYLAAR--------LQETRLSG--KDYIQAFLGLCRG-------------------- 294
               :|:  |||..|        |.|..::.  ..:.:..|..|:|
Human   244 ---RAL--RYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKV 303

  Fly   295 -----PLQRALRDHTKLAEVVDAVCKEE----------------INRKGQII------DP----- 327
                 |:.:.|.:|...|.:.|.|...|                .||..:::      ||
Human   304 PNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTA 368

  Fly   328 ------------------------------------TRLLVTYANELMTK----RQESEEAIIDE 352
                                                ..||..|.:.|:.|    ::.:.|.|..:
Human   369 RDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAK 433

  Fly   353 LKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNK--KMANFVTRCIYVQL 415
            ||.::..::::.::..|:..:...|..|.|.:.|....:|..|...|.:  ..|::|.: :....
Human   434 LKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNK-LARMF 497

  Fly   416 RDVDKLRTLKKEFQD-HLNSKGIKLGFDFRPKCFKNDG----SFENFNLTLPDELQQAWKEFRIF 475
            :|:.....|.:.|:: |.|:| :.|..|.......|.|    |.|...::||.||:....|...|
Human   498 QDIKVSEDLNQAFKEMHKNNK-LALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEF 561

  Fly   476 YEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHER----FTEQELVTA 536
            |  :|..|...:..::.:|:|.||.......|.|||:|.|:|||..:|:..|    |...:|.|.
Human   562 Y--KKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATE 624

  Fly   537 L-GVEL-ETLQE--ALKQIKFLVYIEVNKVNYIEINMDFT-------NRKRRLFCNEPLPR---- 586
            | ..|| .||..  |..::|..|.:...:||..:   |||       |::..|..|..:.:
Human   625 LPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPK---DFTEGTLFSVNQEFSLIKNAKVQKRGKI 686

  Fly   587 -----------KMRKIEEKSEIELKIRRDKQVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKP 640
                       :||:.|.:..::|:|.|.::   ||::|||.:|::..::|.:.:.|.||:...|
Human   687 NLIGRLQLTTERMREEENEGIVQLRILRTQE---AIIQIMKMRKKISNAQLQTELVEILKNMFLP 748

  Fly   641 QVSFIKKRLDYLVEREYLERD-NYYNIYRYL 670
            |...||:::::|:|.:|:.|| :..|.:.|:
Human   749 QKKMIKEQIEWLIEHKYIRRDESDINTFIYM 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	170/795 (21%)
		CULLIN	362..500	CDD:214545	34/144 (24%)
		Cullin_Nedd8	606..661	CDD:287520	17/54 (31%)
CUL5	NP_003469.2	Cullin	19..672	CDD:395716	146/699 (21%)
CUL5	NP_003469.2	Cullin_Nedd8	711..771	CDD:402267	21/62 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820