Protein Alignment Cul6 and Cul5

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_082083.3
• Gene: Cul5 / 75717
• MGIID: 1922967
• Length: 780
• Species: Mus musculus
• Alignment Length: 808
• Identity: 176/808 - (21%)
• Similarity: 324/808 - (40%)
• Gaps: 195/808 - (24%)

  Fly    11 FDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDC 75
            :|.|.|:   :|:::.|     .|...|:...|:..::..|.    |::   |....::..|.:.
Mouse    19 WDFMHPI---VLKLLRQ-----ESVTKQQWFDLFSDVHAVCL----WDD---KGSSKIHQALKED 68

  Fly    76 LMKRLKNI-AWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERE--RLKGD 137
            :::.:|.. |.|:.:| ||.   .|:..|:..|..:...|:.|...........:.::  ..|.:
Mouse    69 ILEFIKQAQARVLSHQ-DDT---ALLKAYIVEWRKFFTQCDILPKPFCQLEVTLLGKQSSNKKSN 129

  Fly   138 KETYPIYRLAMISWKELVFEPSVTIL--AAIRLI-LSQMPREYNKSLEYQVYQVLQSIVELYAN- 198
            .|...:.:|.:.:|.|.:|......|  :|::|: ..::...::..|   |..|.:|.|.|.:|
Mouse   130 MEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQL---VIGVRESYVNLCSNP 191

  Fly   199 -DK---YQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMPEIENG 259
             ||   |:|     ..:|.:.:....||::......|:..|.|       :::||...:.|.|.
Mouse   192 EDKLQIYRD-----NFEKAYLDSTERFYRTQAPSYLQQNGVQN-------YMKYADAKLKEEEK- 243

  Fly   260 TQFKAILKRYLAAR--------LQETRLSG--KDYIQAFLGLCRG-------------------- 294
               :|:  |||..|        |.|..::.  ..:.:..|..|:|
Mouse   244 ---RAL--RYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKV 303

  Fly   295 -----PLQRALRDHTKLAEVVDAVCKEE----------------INRKGQII------DP----- 327
                 |:.:.|.:|...|.:.|.|...|                .||..:::      ||
Mouse   304 PNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTA 368

  Fly   328 ------------------------------------TRLLVTYANELMTK----RQESEEAIIDE 352
                                                ..||..|.:.|:.|    ::.:.|.|..:
Mouse   369 RDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAK 433

  Fly   353 LKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNK--KMANFVTRCIYVQL 415
            ||.::..::::.::..|:..:...|..|.|.:.|....:|..|...|.:  ..|::|.: :....
Mouse   434 LKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNK-LARMF 497

  Fly   416 RDVDKLRTLKKEFQD-HLNSKGIKLGFDFRPKCFKNDG----SFENFNLTLPDELQQAWKEFRIF 475
            :|:.....|.:.|:: |.|:| :.|..|.......|.|    |.|...::||.||:....|...|
Mouse   498 QDIKVSEDLNQAFKEMHKNNK-LALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEF 561

  Fly   476 YEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHER----FTEQELVTA 536
            |  :|..|...:..::.:|:|.||.......|.|||:|.|:|||..:|:..|    |...:|.|.
Mouse   562 Y--KKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATE 624

  Fly   537 L-GVEL-ETLQE--ALKQIKFLVYIEVNKVN---------YIEINMDFT---NRK--RRLFCN-- 581
            | ..|| .||..  |..::|..|.:...:||         ...:|.||:   |.|  :|...|
Mouse   625 LPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEGTLFSVNQDFSLIKNAKVQKRGKINLI 689

  Fly   582 ---EPLPRKMRKIEEKSEIELKIRRDKQVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVS 643
               :....:||:.|.:..::|:|.|.::   ||::|||.:|::..::|.:.:.|.||:...||..
Mouse   690 GRLQLTTERMREEENEGIVQLRILRTQE---AIIQIMKMRKKISNAQLQTELVEILKNMFLPQKK 751

  Fly   644 FIKKRLDYLVEREYLERDNY-YNIYRYL 670
            .||:::::|:|..|:.||.. .|.:.|:
Mouse   752 MIKEQMEWLIEHRYIRRDEADINTFIYM 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	171/792 (22%)
Cul5	NP_082083.3	Cullin	19..672	CDD:459983	143/696 (21%)
		Cullin_Nedd8	711..772	CDD:463146	21/63 (33%)