DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and cul1

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001039255.1	Gene:	cul1 / 734121	XenbaseID:	XB-GENE-945766	Length:	776	Species:	Xenopus tropicalis

Alignment Length:	786	Identity:	202/786 - (25%)
Similarity:	343/786 - (43%)	Gaps:	167/786 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VNQIFDD--------YT--SFDGQKLMHLYHLIYKQCAAERNWNN------PAQKN--------- 64
            ::||:||        ||  |....:.|.||..:|..|.:....|.      |..|:
Frog    17 LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGA 81

  Fly    65 ---GRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNR 126
               |..||..|.:.|...|.|:....|:.:|::    ::..|.:.|..|:.|.:.||..|.:.||
Frog    82 QFVGLELYKRLKEFLKNYLTNLLKDGEDLMDES----VLKFYTQQWEDYRFSSKVLNGICAYLNR 142

  Fly   127 NWVERERLKGDKETYPIYRLAMISWKELVFEP---SVT--ILAAI-----------RLI------ 169
            :||.||..:|.|..|.||.||:::|::.:|:|   .||  :|..|           |||
Frog   143 HWVRRECDEGRKGIYEIYSLALVTWRDCLFKPLNKQVTNAVLKLIEKERNGETINTRLISGVVQS 207

  Fly   170 --------------------------------------------LSQMP-REYNKSLEYQVYQVL 189
                                                        |.|.| .||.|..|.::.:.
Frog   208 YVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEE- 271

  Fly   190 QSIVELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMP 254
            |..|::|.::..|| .|..:.:::..||.::.:.:    |||.::.::..:|......    .:.
Frog   272 QRRVQVYLHESTQD-ELARKCEQVLIEKHLEIFHT----EFQNLLDADKNEDLGRMYN----LVS 327

  Fly   255 EIENGTQFKAILKRYLAARLQETRLSG------------KDYIQAFLGLCR---GPLQRALRDHT 304
            .|::|.   ..||:.|...:....|:.            |.|:|..|.:.:   ..:..|..:..
Frog   328 RIQDGL---GELKKLLETHIHNQGLAAIEKCGEAAQNDPKMYVQTVLDVHKKYNALVMSAFNNDA 389

  Fly   305 KLAEVVDAVCKEEINRKG------QIIDPTRLLVTYANELMTKRQES-EEA-IIDELKRIVKCVE 361
            .....:|..|...||...      .......||..|.:.|:.|..:: ||| :.|.|.:::...:
Frog   390 GFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFK 454

  Fly   362 FLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKK 426
            ::.|:..|...|.|.|..|.:::.|.||..|:.|.|.|.:......|..:....:|:...:.|.:
Frog   455 YIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNE 519

  Fly   427 EFQDHL-NSKGIKLGFDFRPKCFKNDGS--FENF-NLTLPDELQQAWKEFRIFYEARKLQSKAII 487
            :|:.|| ||:.:.|.|..:   ..:.||  |:.| ...||.||:::::.|..||.:|....|  :
Frog   520 QFKKHLTNSEPLDLDFSIQ---VLSSGSWPFQQFCTFALPSELERSYQRFTAFYASRHSGRK--L 579

  Fly   488 QLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALK--- 549
            ....:||.||:..:..::.|.|:.||.|||:|:.:|..:.:|.|:|..:..::::.|.:.|:
Frog   580 TWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILVQVLQILL 644

  Fly   550 QIKFLVYIEVN-KVNYIEINMD--------FTNRKRRLFCNEPLPRKMRKIEEKSEIEL---KIR 602
            :.|.||..:.| .|:.:::..|        :.|:|.|:..|.|:     |.|:|.|.|.   .|.
Frog   645 KSKLLVLEDENANVDDVDLKPDILIKLYLGYKNKKLRVNINVPM-----KTEQKQEQETTHKNIE 704

  Fly   603 RDKQ--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLER-DNYY 664
            .|::  :.||||||||.:|.|::.:|:..|..:|..|.||:|..|||.:|.|:|:||||| |...
Frog   705 EDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEK 769

  Fly   665 NIYRYL 670
            :.|.||
Frog   770 DTYSYL 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	200/784 (26%)
		CULLIN	362..500	CDD:214545	40/141 (28%)
		Cullin_Nedd8	606..661	CDD:287520	28/57 (49%)
cul1	NP_001039255.1	Cullin	21..662	CDD:366357	155/662 (23%)
cul1	NP_001039255.1	Cullin_Nedd8	703..770	CDD:214883	31/66 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0003709
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920