Protein Alignment Cul6 and cul1

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001039255.1
• Gene: cul1 / 734121
• XenbaseID: XB-GENE-945766
• Length: 776
• Species: Xenopus tropicalis
• Alignment Length: 786
• Identity: 202/786 - (25%)
• Similarity: 343/786 - (43%)
• Gaps: 167/786 - (21%)

  Fly    25 VNQIFDD--------YT--SFDGQKLMHLYHLIYKQCAAERNWNN------PAQKN--------- 64
            ::||:||        ||  |....:.|.||..:|..|.:....|.      |..|:
 Frog    17 LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGA 81

  Fly    65 ---GRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNR 126
               |..||..|.:.|...|.|:....|:.:|::    ::..|.:.|..|:.|.:.||..|.:.||
 Frog    82 QFVGLELYKRLKEFLKNYLTNLLKDGEDLMDES----VLKFYTQQWEDYRFSSKVLNGICAYLNR 142

  Fly   127 NWVERERLKGDKETYPIYRLAMISWKELVFEP---SVT--ILAAI-----------RLI------ 169
            :||.||..:|.|..|.||.||:::|::.:|:|   .||  :|..|           |||
 Frog   143 HWVRRECDEGRKGIYEIYSLALVTWRDCLFKPLNKQVTNAVLKLIEKERNGETINTRLISGVVQS 207

  Fly   170 --------------------------------------------LSQMP-REYNKSLEYQVYQVL 189
                                                        |.|.| .||.|..|.::.:.
 Frog   208 YVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEE- 271

  Fly   190 QSIVELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMP 254
            |..|::|.::..|| .|..:.:::..||.::.:.:    |||.::.::..:|......    .:.
 Frog   272 QRRVQVYLHESTQD-ELARKCEQVLIEKHLEIFHT----EFQNLLDADKNEDLGRMYN----LVS 327

  Fly   255 EIENGTQFKAILKRYLAARLQETRLSG------------KDYIQAFLGLCR---GPLQRALRDHT 304
            .|::|.   ..||:.|...:....|:.            |.|:|..|.:.:   ..:..|..:..
 Frog   328 RIQDGL---GELKKLLETHIHNQGLAAIEKCGEAAQNDPKMYVQTVLDVHKKYNALVMSAFNNDA 389

  Fly   305 KLAEVVDAVCKEEINRKG------QIIDPTRLLVTYANELMTKRQES-EEA-IIDELKRIVKCVE 361
            .....:|..|...||...      .......||..|.:.|:.|..:: ||| :.|.|.:::...:
 Frog   390 GFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFK 454

  Fly   362 FLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKK 426
            ::.|:..|...|.|.|..|.:::.|.||..|:.|.|.|.:......|..:....:|:...:.|.:
 Frog   455 YIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNE 519

  Fly   427 EFQDHL-NSKGIKLGFDFRPKCFKNDGS--FENF-NLTLPDELQQAWKEFRIFYEARKLQSKAII 487
            :|:.|| ||:.:.|.|..:   ..:.||  |:.| ...||.||:::::.|..||.:|....|  :
 Frog   520 QFKKHLTNSEPLDLDFSIQ---VLSSGSWPFQQFCTFALPSELERSYQRFTAFYASRHSGRK--L 579

  Fly   488 QLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALK--- 549
            ....:||.||:..:..::.|.|:.||.|||:|:.:|..:.:|.|:|..:..::::.|.:.|:
 Frog   580 TWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILVQVLQILL 644

  Fly   550 QIKFLVYIEVN-KVNYIEINMD--------FTNRKRRLFCNEPLPRKMRKIEEKSEIEL---KIR 602
            :.|.||..:.| .|:.:::..|        :.|:|.|:..|.|:     |.|:|.|.|.   .|.
 Frog   645 KSKLLVLEDENANVDDVDLKPDILIKLYLGYKNKKLRVNINVPM-----KTEQKQEQETTHKNIE 704

  Fly   603 RDKQ--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLER-DNYY 664
            .|::  :.||||||||.:|.|::.:|:..|..:|..|.||:|..|||.:|.|:|:||||| |...
 Frog   705 EDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEK 769

  Fly   665 NIYRYL 670
            :.|.||
 Frog   770 DTYSYL 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	200/784 (26%)
cul1	NP_001039255.1	Cullin	21..662	CDD:459983	155/662 (23%)
		Cullin_Nedd8	706..768	CDD:463146	30/61 (49%)