Protein Alignment Cul6 and Cul5

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: XP_006243152.1
• Gene: Cul5 / 64624
• RGDID: 621742
• Length: 828
• Species: Rattus norvegicus
• Alignment Length: 767
• Identity: 176/767 - (22%)
• Similarity: 325/767 - (42%)
• Gaps: 140/767 - (18%)

  Fly    11 FDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDC 75
            :|.|.|:   :|:::.|     .|...|:...|:..::..|.    |::   |....::..|.:.
  Rat    94 WDFMRPI---VLKLLRQ-----ESVTKQQWFDLFSDVHAVCL----WDD---KGSSKIHQALKED 143

  Fly    76 LMKRLKNI-AWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERE--RLKGD 137
            :::.:|.. |.|:.:| ||.   .|:..|:..|..:...|:.|...........:.::  ..|.:
  Rat   144 ILEFIKQAQARVLSHQ-DDT---ALLKAYIVEWRKFFTQCDILPKPFCQLEVTLLGKQSSNKKSN 204

  Fly   138 KETYPIYRLAMISWKELVFEPSVTIL--AAIRLI-LSQMPREYNKSLEYQVYQVLQSIVELYAN- 198
            .|...:.:|.:.:|.|.:|......|  :|::|: ..::...::..|   |..|.:|.|.|.:|
  Rat   205 MEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQL---VIGVRESYVNLCSNP 266

  Fly   199 -DK---YQD---------------VSLPSRIDKIFTEKVMDF------------YKSTTLHEFQK 232
             ||   |:|               ...||.:.:...:..|.:            :|.|.|.|.|.
  Rat   267 EDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYLMECCVNALVTSFKETILAECQG 331

  Fly   233 IVVSNDYKDFKHFLRYACLAMPEIENGTQ--FKAILKRYLAARL-------QETRLSGKDYIQAF 288
            ::..|:.:  |..|.::  .|.::..|.:  .|.:.:..::|.|       :......:.|::..
  Rat   332 MIKRNETE--KLHLMFS--LMDKVPGGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQL 392

  Fly   289 LGLCR------------GPLQRALRDHTKLAEVVDA-VCKEEINRK----GQIIDP----TRLLV 332
            |.|..            .|.....||....|.|.|| :.|.|:..|    |....|    ..||.
  Rat   393 LTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLA 457

  Fly   333 TYANELMTK----RQESEEAIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVES 393
            .|.:.|:.|    ::.:.|.|..:||.::..::::.::..|:..:...|..|.|.:.|....:|.
  Rat   458 NYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEE 522

  Fly   394 IMYSLLNK--KMANFVTRCIYVQLRDVDKLRTLKKEFQD-HLNSKGIKLGFDFRPKCFKNDG--- 452
            .|...|.:  ..|::|.: :....:|:.....|.:.|:: |.|:| :.|..|.......|.|
  Rat   523 NMVEWLREVGMPADYVNK-LARMFQDIKVSEDLNQAFKEMHKNNK-LALPADSVNIKILNAGAWS 585

  Fly   453 -SFENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQM 516
             |.|...::||.||:....|...||  :|..|...:..::.:|:|.||.......|.|||:|.|:
  Rat   586 RSSEKVFVSLPTELEDLIPEVEEFY--KKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQL 648

  Fly   517 AVLMLFNRHER----FTEQELVTAL-GVEL-ETLQE--ALKQIKFLVYIEVNKVN---------Y 564
            |||..:|:..|    |...:|.|.| ..|| .||..  |..::|..|.:...:||         .
  Rat   649 AVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEGTL 713

  Fly   565 IEINMDFT---NRK--RRLFCN-----EPLPRKMRKIEEKSEIELKIRRDKQVDAAIVRIMKGQK 619
            ..:|.||:   |.|  :|...|     :....:||:.|.:..::|:|.|.::   ||::|||.:|
  Rat   714 FSVNQDFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQE---AIIQIMKMRK 775

  Fly   620 QLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERDNY-YNIYRYL 670
            ::..::|.:.:.|.||:...||...||:::::|:|.:|:.||.. .|.:.|:
  Rat   776 KISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDEADINTFIYM 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	171/751 (23%)
Cul5	XP_006243152.1	Cullin	94..720	CDD:459983	143/655 (22%)
		Cullin_Nedd8	759..820	CDD:463146	21/63 (33%)