Protein Alignment Cul6 and cul4b

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001116316.1
• Gene: cul4b / 560313
• ZFINID: ZDB-GENE-041008-208
• Length: 864
• Species: Danio rerio
• Alignment Length: 761
• Identity: 169/761 - (22%)
• Similarity: 309/761 - (40%)
• Gaps: 185/761 - (24%)

  Fly    30 DDYTSFDGQKLM-----------------HLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLM 77
            ::||:...|||.                 .||..:...|:     :..:.|..:.|.:|..|.:.
Zfish   161 ENYTNETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCS-----HKISAKLYKQLRVVCEDHIK 220

  Fly    78 KRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYP 142
            .::...   .|:.||.   :..:.|..:.|..:.|....:.......:|.:|.:..:      .|
Zfish   221 AQIDQF---REDALDS---VLFLKKIDKCWQDHCRQMIMIRSIFLFLDRTYVLQNSM------LP 273

  Fly   143 --------IYRLAMISWKELVFEPSVTILAAIRLILSQMPREYNKSLEYQVYQVLQSIVELYAN- 198
                    ::|..:||  :|..: |.||...:.||      |..:|.|.....:|:|::.:.::
Zfish   274 SIWDMGLELFRFYIIS--DLKVQ-SKTIDGILLLI------ERERSGEAVDRSLLRSLLSMLSDL 329

  Fly   199 DKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFL-----RYACLAMPEIEN 258
            ..|||     ..::.|.|:....|.:    |.|:::...:..::.|.:     ..|...:..::.
Zfish   330 QIYQD-----SFEQRFLEETNRLYAA----EGQRLMQEREVPEYLHHVNKRLEEEADRVITYLDQ 385

  Fly   259 GTQ---------------FKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRAL-------- 300
            .||               ..|||::.|...|.|.|:.....:.......||.:|..|
Zfish   386 STQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIK 450

  Fly   301 -----------RDHTKLAEVVD---------AVC--KEE-------------INRKGQIIDPTRL 330
                       :|.|.:.|::|         .||  |.|             ||::..  .|..|
Zfish   451 AFGSTIVINPEKDKTMVQELLDFKDKVDHIIDVCFMKNEKFVNGMKEAFETFINKRPN--KPAEL 513

  Fly   331 LVTYANELMTKRQESEEAIIDELKRIVKCV----EFLSDEYKFIDMYLKALRIRQINETSTSDGV 391
            :..|.:..:  |..::||..:||::::..:    .|:..:..|...|.|.|..|.:...|.|...
Zfish   514 IAKYVDSKL--RAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDA 576

  Fly   392 ESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIK---------LGFDFRPKC 447
            |..|.|.|..:.....|..:....:|::..:.:..:|:.|:..:.|.         |...:.|
Zfish   577 EKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQHMQCQNIPGNIELTVNILTMGYWP-- 639

  Fly   448 FKNDGSFENFNLTLPDELQQAWKEFRIFY----EARKLQSKAII---QLNNELSSGEITCHLNQS 505
                 ::....:.||.|:.:..:.|:.||    ..||||.::.:   .|..|...|:..
Zfish   640 -----TYVPMEVHLPAEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKE------ 693

  Fly   506 VYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI---KFLVYIEVNKVNYIE- 566
               |:||..|..||::||..|.|:.:::..|.|:|...|:..|:.:   |..|..::.|...:|
Zfish   694 ---LQVSLFQTLVLLMFNEGEEFSLEDIKLATGIEDSELRRTLQSLACGKARVLTKIPKSKDVED 755

  Fly   567 -----INMDFTNRKRRLFCNEPLPRKMRK-IEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEY 623
                 .|.||.::..|:..|:   .:|:: :||::....::.:|:  |:|||||||||.:|.|.:
Zfish   756 GDKFSCNDDFKHKLFRIKINQ---IQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSH 817

  Fly   624 SELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERD----NYYN 665
            :.|:|.||.:||..|||  :.:|||::.|::|:|:|||    |.||
Zfish   818 NLLVSEVYNQLKFPVKP--ADLKKRIESLIDRDYMERDKENPNQYN 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	169/761 (22%)
cul4b	NP_001116316.1	Cullin	168..765	CDD:459983	126/651 (19%)
		Cullin_Nedd8	796..856	CDD:463146	31/61 (51%)