Protein Alignment Cul6 and cul4a

DIOPT Version :9

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001015893.1
• Gene: cul4a / 548647
• XenbaseID: XB-GENE-1014775
• Length: 753
• Species: Xenopus tropicalis
• Alignment Length: 763
• Identity: 169/763 - (22%)
• Similarity: 294/763 - (38%)
• Gaps: 182/763 - (23%)

  Fly    30 DDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRLKNI------AWVME 88
            |.||....|||....:.|....:.:.|.....|.........:|..|.|:|:.:      |.:.:
 Frog    50 DSYTQDTWQKLQEAVNAIESSTSIKYNLEELYQAVENLCSYKVSHTLYKQLRQVCEEHMKAQIHQ 114

  Fly    89 NQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYP--------IYR 145
            .:.|.......:.|....|..:.|....:.......:|.:|.:..:      .|        ::|
 Frog   115 FREDSLDSFLFLKKVNRCWKDHCRQMIMIRSIFLFLDRTYVLQNSM------LPSIWDMGLELFR 173

  Fly   146 LAMISWKELVFEPSVTILAAIRLILSQ-----MPREYNKSL-----EYQVY------QVLQSIVE 194
            ..::|.:.:..:   ||...::||..:     :.|...:||     :.|||      :.|:....
 Frog   174 CHVVSDRMVQIK---TIDGILKLIEQERSGEAVDRSLLRSLLGMLSDLQVYKESFETKFLEETNC 235

  Fly   195 LYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLH--------EFQKIVVSNDYKDFKHFLRYACL 251
            |||.:.          .::..|:.:..|    ||        |..:::...|:...|..:  ||:
 Frog   236 LYAAEG----------QRLMQEREVPEY----LHHVNRRLEEEVDRVITYLDHGTHKPLI--ACV 284

  Fly   252 AMPEIENGTQFKAILKRYLAARLQE-------------TRLSG---------KDYIQAF-LGLCR 293
            ....:  |....|||::.|...|.|             :|:.|         .:||:.| .||..
 Frog   285 EKQLL--GEHLTAILQKGLKNMLDENRDPELTLMYQLFSRVKGGQIILLQHWGEYIKNFGSGLVI 347

  Fly   294 GP------LQRALRDHTKLAEVVDAVC-----------KEE----INRKGQIIDPTRLLVTYANE 337
            .|      :|..|.....:..::| ||           ||.    |||:..  .|..|:..|.:.
 Frog   348 NPEKDKDMVQELLDFKDNVDHIID-VCFQKNEKFVNTMKESFETFINRRAN--KPAELIAKYVDS 409

  Fly   338 LMTKRQESEEAIIDELKRIVKCV----EFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSL 398
            .:  |..::||..:||:|::..:    .|:..:..|...|.|.|..|.:...|.|...|..|.|.
 Frog   410 KL--RSGNKEATDEELERLLDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSK 472

  Fly   399 LNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIKLGFDFRPKCFKNDGSFENFNLT--- 460
            |..:.....|..:....:|::..:.:..:|:.|:                :|.....|.:||
 Frog   473 LKHECGAAFTSKLEGMFKDMELSKDVMVQFKQHM----------------QNHSDPGNIDLTVNI 521

  Fly   461 ---------------LPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEITCHLNQSVYILE 510
                           ||.|:.:..:.|:.||..:  .|...:|..:.|....:.....:....|:
 Frog   522 LTMGYWPTYTPVDVHLPAEMVKLQEIFKAFYLGK--HSGRRLQWQSTLGHAVLKADFKEEKKELQ 584

  Fly   511 VSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI---KFLVYIEVNKVNYIE------ 566
            ||..|..||:|||:.:.|..:|:....|:|...|:..|:.:   |..|..:..|...:|
 Frog   585 VSLFQTLVLLLFNKGDEFGFEEIKITTGIEDNELRRTLQSLACGKARVLNKSPKSKDVEDGDRFC 649

  Fly   567 INMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKIR--------RDKQVDAAIVRIMKGQKQLEY 623
            .|.||.::..|:        |:.:|:.|..:|.::.        |..|:|||||||||.:|.|.:
 Frog   650 FNADFKHKLYRI--------KINQIQMKETVEEQVNTTERVFQDRQYQIDAAIVRIMKMRKTLTH 706

  Fly   624 SELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERD-NYYNIYRYL 670
            :.|:|.:|.:||..|||  ..:|||::.|::|:|:||| :....|.||
 Frog   707 NLLVSELYNQLKFPVKP--GDLKKRIESLIDRDYMERDKDNAKQYHYL 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	167/761 (22%)
		CULLIN	362..500	CDD:214545	29/155 (19%)
		Cullin_Nedd8	606..661	CDD:287520	27/54 (50%)
cul4a	NP_001015893.1	Cullin	58..653	CDD:279260	126/644 (20%)
		CULLIN	436..576	CDD:214545	29/157 (18%)
		Cullin_Nedd8	682..747	CDD:214883	30/66 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010