DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and Cul5

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_651665.2	Gene:	Cul5 / 43434	FlyBaseID:	FBgn0039632	Length:	852	Species:	Drosophila melanogaster

Alignment Length:	733	Identity:	159/733 - (21%)
Similarity:	283/733 - (38%)	Gaps:	195/733 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 QKLM------HLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRLKNIAWVMENQLDDNKP 96
            :|||      |::|.|..:..........|::||                           |...
  Fly   214 RKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNG---------------------------DAYD 251

  Fly    97 IRLIAKYLEHWVPYQRSCE-KLNLACYHFNRNW----VERERLKGDKE-------TYPIYRLAMI 149
            .:|:....|.:|....:.| ||.:...:|...:    ||..|||..::       .|..|..:.:
  Fly   252 AQLVVGVRESYVNLSSNAEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKL 316

  Fly   150 SWKEL----VFEPS-----------VTILAAIRLILSQMP---REYNKSLEYQVYQVLQSI---- 192
            ..:|:    ..|||           |.|:..:..|:::.|   |:|.......:::::..:
  Fly   317 REEEVRAKRYLEPSSFSILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGV 381

  Fly   193 -VELYANDKYQDVSLPSRIDKIFTEKVM----DFYKSTTLHEFQKI--VVSNDYKDFKHFLRYAC 250
             ||....|..:.:......|.:...:|:    :.|....|..|.|.  :|.|.:.|...||....
  Fly   382 GVEPMMGDLQRHIMSAGLADMLSASEVITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARD 446

  Fly   251 LAMPEIENGTQ-FKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRALRDHTKLAEVVDAVC 314
            :|...:.|.|. ||..|...:|.|       |..|                       ...::.|
  Fly   447 IAFKTVVNDTSVFKMELPTSIANR-------GVKY-----------------------TAPESKC 481

  Fly   315 KEEINRKGQIIDPTRLLVTYANEL-----MTKRQESEEAIID-ELKRIVKCVEFLSDEYKFIDMY 373
            .|             ||..|.:.|     ::||..||:  || .|:.::..:::::::..|:..:
  Fly   482 PE-------------LLANYCDMLLRRTPLSKRLTSEQ--IDARLRDVLLVLKYVNNKDVFMRYH 531

  Fly   374 LKALRIRQINETST-SDGVESIMYSLLNKKM-ANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKG 436
            ...|..|.|..||. |:..|.|:..|....| |::|.|              |.:.|||
  Fly   532 KVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNR--------------LARMFQD------ 576

  Fly   437 IKLGFD----FRPKCFKND---------GSF----ENFNLTLPDELQQAWKEFRIFYEARKLQSK 484
            ||:..|    ||....::|         |::    |..:::||.||:....:...||  :|..|.
  Fly   577 IKVSEDLNTQFRTSISRHDAINIKILNAGAWARCSERVSVSLPIELEDYIPDVEEFY--KKKHSG 639

  Fly   485 AIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFN--RHERFTEQELVTALGVELETLQEA 547
            ..:|..:.:|:|.||...|...|.|:|:|.|||||..:|  :|::.:.:.|..|..:....|:..
  Fly   640 RKLQWYHHMSNGTITFVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRT 704

  Fly   548 L----------KQIKFLVYIEVNK-VNYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKI 601
            |          |||..:....::. .::.|..|.:.|::..:..|....|: .|:.....::|..
  Fly   705 LWSLVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRR-GKLNLIGRLQLST 768

  Fly   602 RRDKQVD-------------AAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLV 653
            .|.:|.|             .||::|||.:|::..:.|...:.:.||:...|....||::|::|:
  Fly   769 ERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLI 833

  Fly   654 EREYLER-DNYYNIYRYL 670
            |.:|:.| |:..|::.|:
  Fly   834 ENKYMRRDDDDINMFIYV 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	158/731 (22%)
		CULLIN	362..500	CDD:214545	38/156 (24%)
		Cullin_Nedd8	606..661	CDD:287520	19/68 (28%)
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	132/622 (21%)
		CULLIN	520..655	CDD:214545	38/156 (24%)
		Cullin_Nedd8	779..846	CDD:214883	18/66 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850