Protein Alignment Cul6 and cul1b

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_998660.1
• Gene: cul1b / 406816
• ZFINID: ZDB-GENE-040426-2887
• Length: 774
• Species: Danio rerio
• Alignment Length: 783
• Identity: 201/783 - (25%)
• Similarity: 346/783 - (44%)
• Gaps: 163/783 - (20%)

  Fly    25 VNQIFDD--------YT--SFDGQKLMHLYHLIYKQCAAERN-------WNNPAQKN-------- 64
            :.||:||        ||  |....:.|.||..:|..|.:...       .:.|::|.
Zfish    17 LEQIWDDLRSGIQQVYTRQSMARSRYMELYTHVYNYCTSVHQARPTGIPSSKPSKKTPTPGGAQF 81

  Fly    65 -GRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNW 128
             |..||..|.|.|...|.|:....|:.:|::    ::..|.:.|..|:.|.:.|:..|.:.||:|
Zfish    82 VGLELYKRLKDFLRSYLTNLLKDGEDLMDES----VLKFYTQQWEDYRFSSKVLDGICAYLNRHW 142

  Fly   129 VERERLKGDKETYPIYRLAMISWKELVFEP---SVTILAAIRLI--------------------- 169
            |.||..:|.|..|.||.||:.:|:|.:|.|   .|| .|.::|:
Zfish   143 VRRECDEGRKGIYEIYSLALATWRECLFRPLNKQVT-NAVLKLVEKERNGETINTRLVSGVVQSY 206

  Fly   170 -------------------------------------------LSQMP-REYNKSLEYQVYQVLQ 190
                                                       |.|.| .||.|..|.::.:. |
Zfish   207 VELGLNEDDAFVKGPTLSVYKEYFEAQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEE-Q 270

  Fly   191 SIVELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMPE 255
            ..|::|.::..|| .|..:.:::..||.::.:.:    |||.::.::..:|......    .:..
Zfish   271 RRVQVYLHESTQD-ELARKCEQVLIEKHLEIFHT----EFQNLLDADKNEDLGRMYN----LVSR 326

  Fly   256 IENGT-QFKAILKRY-----LAA--RLQETRLSG-KDYIQAFLGLCR---GPLQRALRDHTKLAE 308
            |.:|. :.|.:|:.:     |||  :..::.|:. |.|:|..|.:.:   ..:..|..:......
Zfish   327 ITDGLGELKKLLESHIHNQGLAAIEKCGDSALNDPKMYVQTTLDVHKKYNALVMSAFNNDAGFVA 391

  Fly   309 VVDAVCKEEIN-----RKGQIIDPT-RLLVTYANELMTKRQES-EEA-IIDELKRIVKCVEFLSD 365
            .:|..|...||     |..|....: .||..|.:.|:.|..:: ||| :.|.|.:::...:::.|
Zfish   392 ALDKACGRFINNNAVTRMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIED 456

  Fly   366 EYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQD 430
            :..|...|.|.|..|.:::.|.||..|:.|.|.|.:......|..:....:|:...:.|.::|:.
Zfish   457 KDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKK 521

  Fly   431 HL-NSKGIKLGFDFRPKCFKNDGSF---ENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNN 491
            || ||:.:.|.|..:   ..:.||:   ::....||.||:::::.|..||.:|....|  :....
Zfish   522 HLSNSEPLDLDFSIQ---VLSSGSWPFQQSCTFALPSELERSYQRFTAFYGSRHSGRK--LTWLY 581

  Fly   492 ELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALK---QIKF 553
            .||.||:..:..::.|.|:.||.|||:|:.||....::.|:|..:..::.:.|.:.|:   :.|.
Zfish   582 HLSKGELVTNCFKNRYTLQASTFQMAILLQFNTENCYSVQQLADSTQIKTDILVQVLQILLKSKL 646

  Fly   554 LVYIEVNKVN----------YIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIEL---KIRRDK 605
            || :|....|          .|::.:.:.|:|.|:..|.|:     |.|:|.|.|.   .|..|:
Zfish   647 LV-LEDENANIDEMDFKPDTLIKLFLGYKNKKLRVNINVPM-----KTEQKQEQETTHKNIEEDR 705

  Fly   606 Q--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLER-DNYYNIY 667
            :  :.||||||||.:|.|::.:|::.|..:|..|.||:|..|||.:|.|:|:||||| |...:.|
Zfish   706 KLLIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTY 770

  Fly   668 RYL 670
            .||
Zfish   771 SYL 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	199/781 (25%)
cul1b	NP_998660.1	Cullin	21..660	CDD:459983	154/659 (23%)
		Cullin_Nedd8	704..766	CDD:463146	30/61 (49%)