DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and Cul2

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	XP_006254134.1	Gene:	Cul2 / 361258	RGDID:	1310644	Length:	745	Species:	Rattus norvegicus

Alignment Length:	791	Identity:	158/791 - (19%)
Similarity:	309/791 - (39%)	Gaps:	178/791 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRVKRISNYFDSMLPLIDNILQVV----------NQIFDDYTSFDGQKLMHLYHLIYKQCAAER 55
            |:...|:.::.::...|:..|..||          |..|.|               ||..|.|
  Rat     1 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSD---------------IYALCVA-- 48

  Fly    56 NWNNPAQKNGRSLYIVLSDCLMKRLKNI-AWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNL 119
             :..|.   |..||......|...:::: ..|:|::      .:::..|..:|..|.:..:.::.
  Rat    49 -YPEPL---GERLYAETKIFLENHVRHLYKRVLESE------EQVLVMYHRYWEEYSKGADYMDC 103

  Fly   120 ACYHFNRNWVERERLKGDKETY------------PIYRLAMISWKELVFEPSVTILAAIRLILSQ 172
            ...:.|..::::.:|......|            .|..||:..|::|:.||...||  ||::|.:
  Rat   104 LYRYLNTQYIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQNIL--IRMLLRE 166

  Fly   173 MP-----------------------REYNKSLEYQVYQ------VLQSIVELY---ANDKYQDVS 205
            :.                       .:|.|....:.||      .|....|.|   |::..|:.:
  Rat   167 IKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESN 231

  Fly   206 LPSRIDKIFTEKVMDFYK---------------STTLHEFQKIVVSNDYKDFKHFLRYAC--LAM 253
            ...     :.|||:...|               :..:||.|:.:|:    |...||...|  :..
  Rat   232 CSQ-----YMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVA----DHLQFLHSECHSIIR 287

  Fly   254 PEIENGTQFKAILKRYLAARL-----QETRLSGKDYIQAFLGLCRGPL-----QRALRDHTKLAE 308
            .|.:|......:|.|.:::.|     :..|....:.::|...|.:..:     :..|..|.|..:
  Rat   288 HERKNDMANMYVLLRAVSSGLPHMIEELQRHIHDEGLRATSNLTQEHMPTLFVESVLEVHGKFVQ 352

  Fly   309 VVDAVCKEE--------------INRK--GQIIDPTRLLVTYANELMTKRQE--SEEAIIDELKR 355
            :::.|...:              :|.:  ..:.....||..|.:.|:.|..:  :|..:.|:|..
  Rat   353 LINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTS 417

  Fly   356 IVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDK 420
            .:...:::.|:..|...|.:.|..|.|:..|.|...|..|.:.|.:......|..::....|:..
  Rat   418 FITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSV 482

  Fly   421 LRTLKKEFQDHLNSKG--IKLGFDFR---------PKCFKNDGSFENFNLTLPDELQQAWKEFRI 474
            ...|..:|.:.:.::.  |.||..|:         |.......:|     .:|.||:::.:.|.:
  Rat   483 SADLNNKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTF-----AIPQELEKSVQMFEL 542

  Fly   475 FYEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGV 539
            || ::....:.:..| :.|.:||:..:.....|:..|:|.|||||:.||..|..:.:||..:..:
  Rat   543 FY-SQHFSGRKLTWL-HYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQM 605

  Fly   540 ELETLQEALKQIKFLVYIEVNKVNY------------IEINMDFTNRKRRLFCNEPLPRKMRKIE 592
            ..:.|.:.:|.:     ::|..:|:            ..:||.|::::.:......:.:...:..
  Rat   606 NEKELTKTIKSL-----LDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKDTPQEL 665

  Fly   593 EKSEIELKIRRDKQVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREY 657
            |::...:...|...:.||||||||.:|.|.::.||..|..:.:.|..|.:|.|||.::.|::::|
  Rat   666 EQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQY 730

  Fly   658 LER-----DNY 663
            :||     |.|
  Rat   731 IERSQASADEY 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	153/767 (20%)
		CULLIN	362..500	CDD:214545	31/148 (21%)
		Cullin_Nedd8	606..661	CDD:287520	23/59 (39%)
Cul2	XP_006254134.1	Cullin	14..644	CDD:395716	128/679 (19%)
Cul2	XP_006254134.1	Cullin_Nedd8	675..735	CDD:402267	24/59 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820