DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and Cul4a

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001120773.1	Gene:	Cul4a / 361181	RGDID:	1563853	Length:	759	Species:	Rattus norvegicus

Alignment Length:	753	Identity:	164/753 - (21%)
Similarity:	290/753 - (38%)	Gaps:	162/753 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRLKNI------AWVME 88
            |:||....:||......|....:...|.....|.........:|..|.|:|:.:      |.::.
  Rat    56 DNYTQDTWRKLHEAVKAIQSSTSIRYNLEELYQAVENLCSHKVSPTLYKQLRQVCEDHVQAQILP 120

  Fly    89 NQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAMISWKE 153
            .:.|....:..:.|....|..:.|....:.......:|.:|.:..:...     |:.:.:..::.
  Rat   121 FREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPS-----IWDMGLELFRN 180

  Fly   154 LVFEPSVTILAAIRLILSQMPRE-----YNKSL---------EYQVY------QVLQSIVELYAN 198
            .:....:.....|..||..:.||     .::||         :.|||      :.|:....|||.
  Rat   181 HIISDRMVQSKTIDGILLLIGRERSGEAVDRSLLRSLLSMLSDLQVYKDSFELKFLEETNCLYAA 245

  Fly   199 D---KYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMPEIENGT 260
            :   ..||..:|..::.:  .|.::       .|..:::...|:...|..:  ||:....:  |.
  Rat   246 EGQRLMQDREVPEYLNHV--SKRLE-------EEADRVITYLDHSTQKPLI--ACVEKQLL--GE 297

  Fly   261 QFKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRALRDH---------------------- 303
            ...|||::.|...|.|.|:.....:.......:|. |.||..|
  Rat   298 HLTAILQKGLEQLLDENRVPDLTQMYQLFSRVKGG-QHALLQHWSEYIKTFGTTIVINPEKDKDM 361

  Fly   304 --------TKLAEVVDAVC-----------KEE----INRKGQIIDPTRLLVTYANELMTKRQES 345
                    .|:..||: ||           ||.    ||::..  .|..|:..:.:..:  |..:
  Rat   362 VQDLLDFKDKVDHVVE-VCFQRNERFINLMKESFETFINKRPN--KPAELIAKHVDSKL--RAGN 421

  Fly   346 EEAIIDELKRIVKCVEFLSDEYKFID-------MYLKALRIRQINETSTSDGVESIMYSLLNKKM 403
            :||..:||:||:..:..|   ::||.       .|.|.|..|.:...|.|...|..|.|.|..:.
  Rat   422 KEATDEELERILDKIMIL---FRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHEC 483

  Fly   404 ANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIK---------LGFDFRPKCFKNDGSFENFNL 459
            ....|..:....:|::..:.:...|:.|:.::...         |...:.|       ::....:
  Rat   484 GAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSAPGPIDLTVNILTMGYWP-------TYTPMEV 541

  Fly   460 TLPDELQQAWKEFRIFY----EARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLM 520
            .||.|:.:..:.|:.||    ..|||      |....|....:.....:.....:||..|..||:
  Rat   542 HLPPEMVRLQEVFKTFYLGKHSGRKL------QWQTTLGHAVLKADFKEGKKEFQVSLFQTLVLL 600

  Fly   521 LFNRHERFTEQELVTALGVELETLQEALKQI---KFLVYIEVNKVNYIE------INMDFTNRKR 576
            :||..:.|:.:|:..|.|:|...|:..|:.:   |..|.|:..|...:|      .|.||.::..
  Rat   601 MFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNADFKHKLF 665

  Fly   577 RLFCNEPLPRKMRKIEEKSEIELKIR--------RDKQVDAAIVRIMKGQKQLEYSELISLVYEE 633
            |:        |:.:|:.|..:|.::.        |..|:|||||||||.:|.|.::.|:|.:|.:
  Rat   666 RI--------KINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQ 722

  Fly   634 LKDRVKPQVSFIKKRLDYLVEREYLERD-NYYNIYRYL 670
            ||..|||  ..:|||::.|::|:|:||| :..|.|.|:
  Rat   723 LKFPVKP--GDLKKRIESLIDRDYMERDKDSPNQYHYV 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	163/751 (22%)
		CULLIN	362..500	CDD:214545	30/157 (19%)
		Cullin_Nedd8	606..661	CDD:287520	27/54 (50%)
Cul4a	NP_001120773.1	Cullin	63..660	CDD:395716	121/636 (19%)
Cul4a	NP_001120773.1	Cullin_Nedd8	688..753	CDD:214883	30/66 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820