Protein Alignment Cul6 and Cul4a

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001120773.1
• Gene: Cul4a / 361181
• RGDID: 1563853
• Length: 759
• Species: Rattus norvegicus
• Alignment Length: 753
• Identity: 164/753 - (21%)
• Similarity: 290/753 - (38%)
• Gaps: 162/753 - (21%)

  Fly    30 DDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRLKNI------AWVME 88
            |:||....:||......|....:...|.....|.........:|..|.|:|:.:      |.::.
  Rat    56 DNYTQDTWRKLHEAVKAIQSSTSIRYNLEELYQAVENLCSHKVSPTLYKQLRQVCEDHVQAQILP 120

  Fly    89 NQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAMISWKE 153
            .:.|....:..:.|....|..:.|....:.......:|.:|.:..:...     |:.:.:..::.
  Rat   121 FREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPS-----IWDMGLELFRN 180

  Fly   154 LVFEPSVTILAAIRLILSQMPRE-----YNKSL---------EYQVY------QVLQSIVELYAN 198
            .:....:.....|..||..:.||     .::||         :.|||      :.|:....|||.
  Rat   181 HIISDRMVQSKTIDGILLLIGRERSGEAVDRSLLRSLLSMLSDLQVYKDSFELKFLEETNCLYAA 245

  Fly   199 D---KYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMPEIENGT 260
            :   ..||..:|..::.:  .|.::       .|..:::...|:...|..:  ||:....:  |.
  Rat   246 EGQRLMQDREVPEYLNHV--SKRLE-------EEADRVITYLDHSTQKPLI--ACVEKQLL--GE 297

  Fly   261 QFKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRALRDH---------------------- 303
            ...|||::.|...|.|.|:.....:.......:|. |.||..|
  Rat   298 HLTAILQKGLEQLLDENRVPDLTQMYQLFSRVKGG-QHALLQHWSEYIKTFGTTIVINPEKDKDM 361

  Fly   304 --------TKLAEVVDAVC-----------KEE----INRKGQIIDPTRLLVTYANELMTKRQES 345
                    .|:..||: ||           ||.    ||::..  .|..|:..:.:..:  |..:
  Rat   362 VQDLLDFKDKVDHVVE-VCFQRNERFINLMKESFETFINKRPN--KPAELIAKHVDSKL--RAGN 421

  Fly   346 EEAIIDELKRIVKCVEFLSDEYKFID-------MYLKALRIRQINETSTSDGVESIMYSLLNKKM 403
            :||..:||:||:..:..|   ::||.       .|.|.|..|.:...|.|...|..|.|.|..:.
  Rat   422 KEATDEELERILDKIMIL---FRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHEC 483

  Fly   404 ANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIK---------LGFDFRPKCFKNDGSFENFNL 459
            ....|..:....:|::..:.:...|:.|:.::...         |...:.|       ::....:
  Rat   484 GAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSAPGPIDLTVNILTMGYWP-------TYTPMEV 541

  Fly   460 TLPDELQQAWKEFRIFY----EARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLM 520
            .||.|:.:..:.|:.||    ..|||      |....|....:.....:.....:||..|..||:
  Rat   542 HLPPEMVRLQEVFKTFYLGKHSGRKL------QWQTTLGHAVLKADFKEGKKEFQVSLFQTLVLL 600

  Fly   521 LFNRHERFTEQELVTALGVELETLQEALKQI---KFLVYIEVNKVNYIE------INMDFTNRKR 576
            :||..:.|:.:|:..|.|:|...|:..|:.:   |..|.|:..|...:|      .|.||.::..
  Rat   601 MFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNADFKHKLF 665

  Fly   577 RLFCNEPLPRKMRKIEEKSEIELKIR--------RDKQVDAAIVRIMKGQKQLEYSELISLVYEE 633
            |:        |:.:|:.|..:|.::.        |..|:|||||||||.:|.|.::.|:|.:|.:
  Rat   666 RI--------KINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQ 722

  Fly   634 LKDRVKPQVSFIKKRLDYLVEREYLERD-NYYNIYRYL 670
            ||..|||  ..:|||::.|::|:|:||| :..|.|.|:
  Rat   723 LKFPVKP--GDLKKRIESLIDRDYMERDKDSPNQYHYV 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	163/751 (22%)
Cul4a	NP_001120773.1	Cullin	63..660	CDD:459983	121/636 (19%)
		Cullin_Nedd8	688..753	CDD:214883	30/66 (45%)