DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and Cul4

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	158/738 - (21%)
Similarity:	296/738 - (40%)	Gaps:	173/738 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYL 104
            |..||..:...|         :.|....||..|.:...:.:|....:.|........:.|:.| :
  Fly   142 LEELYQAVVNMC---------SHKMDAQLYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEK-I 196

  Fly   105 EHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAMISWKELVFEPSVTILAAIRLI 169
            .||  :...|:::.:....|  .:::|..:..:...:.|:.:.:..::....:.||.....:..:
  Fly   197 NHW--WLSFCQQMIMIRSIF--LYMDRTYVLQNSTVHSIWDMGLDLFRIHFAQNSVVQKRTVDGL 257

  Fly   170 LSQMPREYNKSLEYQVYQVLQSIVELYANDKYQDVSLPSRIDKIFTEKVMD----FYKSTTLHEF 230
            |:.:.:|...|...:  .:|:|:|.:..:.:....|        |.||.:|    .||:.:..:.
  Fly   258 LTLIEKERQGSTVDR--GLLKSLVRMLCDLQIYTSS--------FEEKFLDATNQLYKAESQRKM 312

  Fly   231 QKIVV-----------SNDYKDFKHFLRYACLAMPEIEN------GTQFKAILKRYLAARLQETR 278
            |::.|           :.:.:..:|:|. :....|.|.|      .....:||::.|.:.|::.|
  Fly   313 QELEVPEYLQHVNKRLAEENERLRHYLD-SSTKHPLIYNVEKELLAEHLTSILQKGLDSLLEDNR 376

  Fly   279 LSGKDYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEINRKGQ--IIDP-------------- 327
            ||.       |.|..|.|.|.....::|....:..    |.:||:  :|||
  Fly   377 LSD-------LTLLYGLLSRVKNGTSELCGNFNGF----IKKKGRTIVIDPEKDKSMVQDLLDFK 430

  Fly   328 ------TRLLVTYANELMTKRQESEEAIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETS 386
                  .|....:..:.....:|:.|..|::  |..|..|.::   |::||     ::|..|:.:
  Fly   431 DKMDVIVRTCFEHNEKFTNSLREAFEFFINQ--RANKPAELIA---KYVDM-----KLRSGNKGT 485

  Fly   387 TSDGVES------IMYSLLNKK-------MANFVTRCIYVQLRDVDK----LRTLKKE------- 427
            |.:.:|.      :::..::.|       ..:...|.:..:...||.    |..||:|
  Fly   486 TDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTS 550

  Fly   428 -----FQDHLNSKGIKLGFDFRPKCFKNDGSFENFNL------------------TLPDELQQAW 469
                 |:|...|:.|.:.  ||.....|:....|.:|                  |:|.:.....
  Fly   551 KLEGMFKDMELSRDINIA--FRGHALSNNRDVHNLDLCVSILTMGYWPTYAPTEVTMPPQFINPQ 613

  Fly   470 KEFRIFY----EARKLQSKAII---QLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHER 527
            :.|..||    ..||||.:..:   .|..:..:|...         |.||..|..||:|||....
  Fly   614 QIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKE---------LLVSLFQALVLLLFNDKPV 669

  Fly   528 FTEQELVTALGVELETLQEALKQI---KFLVYIEVNKVNYI------EINMDFTNRKRRLFCNEP 583
            .:.:|::.|..:|...|:..|:.:   :..|..:..|...|      :.|.:|||:..|:..|:.
  Fly   670 LSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGDQFDFNNEFTNKLFRIKINQI 734

  Fly   584 LPRKMRKIEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIK 646
            ..::..  ||:...|.::.:|:  |:|||||||||.:|.|.::.||:.::.:|...|||  :.:|
  Fly   735 QMKETN--EEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELFNQLTFPVKP--ADLK 795

  Fly   647 KRLDYLVEREYLERD----NYYN 665
            ||::.|::|:|:|||    |.||
  Fly   796 KRIESLIDRDYMERDKDNQNQYN 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	158/738 (21%)
		CULLIN	362..500	CDD:214545	35/191 (18%)
		Cullin_Nedd8	606..661	CDD:287520	25/54 (46%)
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	119/635 (19%)
		CULLIN	503..644	CDD:214545	27/142 (19%)
		Cullin_Nedd8	750..815	CDD:214883	28/66 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467941
Domainoid	1	1.000	52	1.000	Domainoid score	I2831
eggNOG	1	0.900	-	-		E1_COG5647
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850