Protein Alignment Cul6 and Cul1

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 807
• Identity: 218/807 - (27%)
• Similarity: 354/807 - (43%)
• Gaps: 171/807 - (21%)

  Fly     1 MNR------VKRISNYFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAA------ 53
            |||      .:::.|..|....|::.|:||    |:...|....:.|..|..:|..|.:
  Fly     1 MNRSGNSQTTQKLVNLDDIWSELVEGIMQV----FEHEKSLTRSQYMRFYTHVYDYCTSVSAAPS 61

  Fly    54 --ERNWNNPAQKNGRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIR----LIAKYLEHWVPYQR 112
              .......||..|:.||..|...|...|..:       |...|.|.    |:::|.:.|..||.
  Fly    62 GRSSGKTGGAQLVGKKLYDRLEQFLKSYLSEL-------LTKFKAISGEEVLLSRYTKQWKSYQF 119

  Fly   113 SCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAMISWKELVF----EPSVTILAAIRLILSQM 173
            |...|:..|.:.|||||:||..:|.|..|.|||||:::||..:|    || ||     :.:|..:
  Fly   120 SSTVLDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEP-VT-----KAVLKSI 178

  Fly   174 PRE-----YNKSLEYQVYQVLQSIVELYANDKYQDV----------SLPSRI---DKIFTEKVMD 220
            ..|     .|:||   |..|::..|||..|::..|.          :..::.   ...|.||..|
  Fly   179 EEERQGKLINRSL---VRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESD 240

  Fly   221 FYKSTT-------------------------------LH-------------------------E 229
            .:.||.                               ||                         |
  Fly   241 AFLSTNTVTEYLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTE 305

  Fly   230 FQKIVVSNDYKDFKHFLRYACLAMPEIENGTQFKAILKRYL-------AARLQETRLSG--KDYI 285
            ||.::.::...|.|..  |:.:|:.. :|.|..|:||:.::       .|:...|..:.  |.|:
  Fly   306 FQNLLNADRNDDLKRM--YSLVALSS-KNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYV 367

  Fly   286 QAFLGLCR---GPLQRALRDHTKLAEVVDAVCKEEINRKGQII-----DPTRLLVTYANELMTKR 342
            |..|.:.:   ..:..|..:.......:|..|.:.||.....|     ....||..|.:.|:.|.
  Fly   368 QTILDVHKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKS 432

  Fly   343 QESEE--AIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMAN 405
            .::.|  .:.|.|.:::...:::.|:..|...|.|.|..|.:|.||.||..|::|.|.|.:....
  Fly   433 SKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGY 497

  Fly   406 FVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIKLGFDFRPKCFKNDGSFE---NFNLTLPDELQQ 467
            ..|..:....:|:...:.|...|:.:|..|.:.:..||..:.. :.||:.   :.|..||.||::
  Fly   498 EYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVL-SSGSWPFQLSNNFLLPSELER 561

  Fly   468 AWKEFRIFYEARKLQSKAIIQLN--NELSSGEITCHLNQ---SVYILEVSTLQMAVLMLFNRHER 527
            :.::|..||.||....|    ||  .::..||:..::|:   |.|.|:.||.||:||:.||....
  Fly   562 SVRQFNEFYAARHSGRK----LNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLS 622

  Fly   528 FTEQELVTALGVELETLQEALKQI-KFLVYIEV-------NKV---NYIEINMDFTNRKRRLFCN 581
            ||.|:|..    ..:|.||.|.|: :.|:..:|       |.:   :.:|:.:|:.|:|||:..|
  Fly   623 FTVQQLQD----NTQTQQENLIQVLQILLKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININ 683

  Fly   582 EPLPRKMRKIEEKSEIELKIRRDKQ--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSF 644
            :||..:: |:|::: :...|..|::  :.||||||||.:|:|.::.|||.|..:|..|.||:|..
  Fly   684 QPLKTEL-KVEQET-VHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPV 746

  Fly   645 IKKRLDYLVEREYLER-DNYYNIYRYL 670
            |||.:|.|:|:||||| :.:.:.|.||
  Fly   747 IKKCIDILIEKEYLERMEGHKDTYSYL 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	207/775 (27%)
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	168/684 (25%)
		Cullin_Nedd8	704..765	CDD:463146	31/60 (52%)