Protein Alignment Cul6 and Cul2

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Alignment Length: 685
• Identity: 146/685 - (21%)
• Similarity: 273/685 - (39%)
• Gaps: 137/685 - (20%)

  Fly    99 LIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETY------------------PIYR 145
            |:.:|...|:.|.:..:.|:....:.|:..::::::...:..|                  .|:|
  Fly    92 LLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWR 156

  Fly   146 LAMISW--KELVFEPSVTILAAIRLILSQM--PREYNKSLEYQVYQVLQSIVELYANDK------ 200
            |.||.:  .|||           |.||..:  .|..|.:|::...|::..::..:...:
  Fly   157 LYMIEYLSSELV-----------RHILEGIAADRASNGTLDHHRVQIINGVIHSFVEVQDYKKTG 210

  Fly   201 ----YQDVSLPSRID---KIFTEKVMDFYKSTTLHEFQKIVV------SNDYKDFKH-------- 244
                ||::.....::   ..:|::........::.|:.:.|:      |...:.|.|
  Fly   211 SLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQKFLHVSSLPKLR 275

  Fly   245 -------------FLRYACLAMPEIENGTQFK---AILK--------RYLAARLQETRLSGKDYI 285
                         |:...|..|...|.....:   .:||        ..:...|...:..|...:
  Fly   276 KECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTV 340

  Fly   286 QAFLG--LCRGPLQRALRDHTKLAEVV--------------DAVCKEEINRKGQIIDPTR---LL 331
            .|..|  :....::..|:.|.|..|::              |..|...|||:.....|.|   .:
  Fly   341 SALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVINRRPTERQPCRSAEYV 405

  Fly   332 VTYANELMTKRQESEEAIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMY 396
            ..|.:.|:.|.:..|..|..:|...:...:::.|:..:...|.:.|..|.|:|.|.|...|..|.
  Fly   406 AKYCDTLLKKSKTCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMI 470

  Fly   397 SLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIKLGFDFRPKCFKND----GSFENF 457
            :.|.:......|..::....|:.....|..:|..||....:.||.:...|..:..    ||.:..
  Fly   471 NRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVI 535

  Fly   458 NLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEI-TCHLNQSVYILEVSTLQMAVLML 521
            ...:|.|.:::.|.|..:|  .||.|...:...:.:..||: ..||.:| ||:.:.|.|||:::|
  Fly   536 PFAVPQEFEKSIKMFEDYY--HKLFSGRKLTWLHHMCHGELKLSHLKKS-YIVTMQTYQMAIILL 597

  Fly   522 FNRHERFTEQELVTALGVELETLQEALKQIKFLVYIEVNKVN----------YIEINMDFTNRKR 576
            |...:..:.:|:...|.:..||.|:.::.|     ||...:|          .||:|:|:||::.
  Fly   598 FETCDSLSCREIQNTLQLNDETFQKHMQPI-----IESKLLNASSENLAGETRIELNLDYTNKRT 657

  Fly   577 RLFCNEPLPRKMRKIEEKSEIELKIR---RDKQ--VDAAIVRIMKGQKQLEYSELISLVYEELKD 636
            :...:..|.:     |...|:|..|.   .|::  :.||||||||.:|.|:::.||..|....|.
  Fly   658 KFKISSALQK-----ETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKV 717

  Fly   637 RVKPQVSFIKKRLDYLVEREYLERD-NYYNIYRYL 670
            ...|.::.|||.::.|::::|:||. |..:.|.|:
  Fly   718 SFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYM 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	145/683 (21%)
Cul2	NP_610117.1	Cullin	14..652	CDD:459983	112/578 (19%)
		Cullin_Nedd8	683..745	CDD:463146	23/61 (38%)