Protein Alignment Cul6 and cul5a

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001314988.1
• Gene: cul5a / 327215
• ZFINID: ZDB-GENE-030131-5426
• Length: 780
• Species: Danio rerio
• Alignment Length: 819
• Identity: 170/819 - (20%)
• Similarity: 320/819 - (39%)
• Gaps: 217/819 - (26%)

  Fly    11 FDSMLPLIDNILQ----VVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIV 71
            :|.|.|::..:|:    ...|.||.::.            ::..|.    |::   |....::..
Zfish    19 WDLMRPIVLKLLRQESVTKQQWFDQFSD------------VHAVCL----WDD---KGPAKIHQA 64

  Fly    72 LSDCLMKRLKNI-AWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERE--R 133
            |.:.::..:|.. |.|:.:| ||.   .|:..|:..|..:...|:.|...........:.::  .
Zfish    65 LKEDILDFIKQAQARVLSHQ-DDT---ALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSS 125

  Fly   134 LKGDKETYPIYRLAMISWKELVFEPSVTIL--AAIRLI-LSQMPREYNKSLEYQVYQVLQSIVEL 195
            .|.:.|...:.:|.:.:|.|.:|......|  :|::|: ..::...::..|   |..|.:|.|.|
Zfish   126 KKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQL---VIGVRESYVNL 187

  Fly   196 YAN--DK---YQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMPE 255
            .:|  ||   |:|     ..:|.:.:....||::......|:..|.|       :::||...:.|
Zfish   188 CSNPEDKLQIYRD-----NFEKSYLDSTERFYRTQAPSYLQQNGVQN-------YMKYADAKLRE 240

  Fly   256 IENGTQFKAILKRYLAAR--------LQETRLSG--KDYIQAFLGLCRG---------------- 294
            .|.    :|:  |||..|        |.|..::.  ..:.:..|..|.|
Zfish   241 EEK----RAL--RYLETRRECNSVQALMECCVNALVTSFKETILAECPGMIKRNETDKLHLMFSL 299

  Fly   295 ---------PLQRALRDHTKLAEVVDAVCKEE----------------INRKGQII------DP- 327
                     |:.:.|.:|...|.:.|.|...|                .||..:::      ||
Zfish   300 MDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPR 364

  Fly   328 ----------------------------------------TRLLVTYANELMTK----RQESEEA 348
                                                    ..||..|.:.|:.|    ::.:.|.
Zfish   365 FLTARDKAYKAVVNDATIFKLELPMKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSED 429

  Fly   349 IIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNK--KMANFVTRC- 410
            |..:||.::..::::.::..|:..:...|..|.|.:.|....:|..|...|.:  ..|::|.:.
Zfish   430 IELKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLA 494

  Fly   411 -IYVQLRDVDKLRTLKKEFQDH------LNSKGIKLGFDFRPKCFKNDG----SFENFNLTLPDE 464
             ::..::..:.|..:.||...|      .:|..||:         .|.|    |.|...::||.|
Zfish   495 RMFQDIKVSEDLNQVFKEMHKHNKLALPADSVNIKI---------LNAGAWSRSSEKVFVSLPTE 550

  Fly   465 LQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHER-- 527
            |:....|...||  :|..|...:..::.:|:|.||.......|.|||:|.|:|||..:|:..|
Zfish   551 LEDLIPEVEDFY--KKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREK 613

  Fly   528 --FTEQELVTAL-GVEL-ETLQE--ALKQIKFLVYIEVNKV----NYIEINMDFTNRKRRLFCNE 582
              |...:|.|.| ..|| .||..  |..::|..|.:...:|    ::.:..:.|.|::..|..|.
Zfish   614 ISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVSSPKDFTDSTLFFVNQEFSLIKNS 678

  Fly   583 PLPR---------------KMRKIEEKSEIELKIRRDKQVDAAIVRIMKGQKQLEYSELISLVYE 632
            ...:               :||:.|.:..::|:|.|.::   ||::|||.:|::..::|.:.:.|
Zfish   679 KAQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQE---AIIQIMKMRKKITNAQLQTELVE 740

  Fly   633 ELKDRVKPQVSFIKKRLDYLVEREYLERDNY-YNIYRYL 670
            .||:...||...||:::::|:|.:|::||.. .|.:.|:
Zfish   741 ILKNMFLPQKKMIKEQIEWLIEHKYIKRDETDINTFIYM 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	165/799 (21%)
cul5a	NP_001314988.1	Cullin	19..672	CDD:459983	141/707 (20%)
		Cullin_Nedd8	711..772	CDD:463146	21/63 (33%)