Protein Alignment Cul6 and cul3a

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_955985.2
• Gene: cul3a / 324655
• ZFINID: ZDB-GENE-030131-3376
• Length: 774
• Species: Danio rerio
• Alignment Length: 810
• Identity: 169/810 - (20%)
• Similarity: 298/810 - (36%)
• Gaps: 214/810 - (26%)

  Fly     5 KRISNYFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLY 69
            |.::|.:|    |:.|.:|.:.:..:...||:     .||...|...         ..|:|..||
Zfish    34 KYVNNIWD----LLKNAIQEIQRKNNSGLSFE-----ELYRNAYTMV---------LHKHGEKLY 80

  Fly    70 IVLSDCLMKRLKN-IAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERER 133
            ..|.:.:.:.|.| :...:.:.|::|    .:....:.|..:|.:...:.....:.:|.:|::..
Zfish    81 TGLREVVTEHLINKVREDVLHSLNNN----FLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNN 141

  Fly   134 LKGDKETYPIYRLAMISWKELVFEPSVTILAAIR-----LILSQMPRE----------------- 176
            ::.      :|.|.:|     :|...|.....||     .:|..:.||
Zfish   142 VEN------VYNLGLI-----IFRDQVVRYGCIRDHLRQTLLDMIARERRGEVVDRGAIRNACQM 195

  Fly   177 -----------YNKSLEY-------QVYQ-------------VLQSIVELYANDKYQDVSLPSRI 210
                       |.:..|.       :.:|             |....||...|::.:.|.  ..:
Zfish   196 LMVLGLEGRSVYEEDFEIPFLDMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVM--HCL 258

  Fly   211 DKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLR------YACL--AMPEIENGTQFKAILK 267
            ||...|.::...:...:.:..|.:|..:.....|.|:      .||:  ....:.||      ||
Zfish   259 DKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFGRVPNG------LK 317

  Fly   268 RYLAARLQETRLSGK-------------DYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEI- 318
            ..........|..||             ||||..|.| :....|.|::...    .|.:.|:.|
Zfish   318 TMCECMSWYLREQGKALVSEEGEGKNPVDYIQGLLDL-KSRFDRFLQESFN----NDRLFKQTIA 377

  Fly   319 ---------NRKGQIIDPTRLLVTYANELMTK-----RQESEEAIIDELKRIVKCVEFLSDEYKF 369
                     |.:.     ...|..:.::.:.|     .::..|:|:|:...:.:   |:.::..|
Zfish   378 GDFEYFLNLNSRS-----PEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFR---FMQEKDVF 434

  Fly   370 IDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNS 434
            ...|.:.|..|.:...|.||..|..|.|.|..:.....|..:....||:....|...||:.||.:
Zfish   435 ERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRHHLQT 499

  Fly   435 KGIKL-GFDF---------------RPKCFKNDGSFENFNLTLPDELQQAWKEFRIFYEARKLQS 483
            ..:.| |.|.               .|||            .:|...:.|::.||.||.|:  .|
Zfish   500 SQVSLCGVDLTVRVLTTGYWPTQSATPKC------------NIPPSPRHAFEVFRRFYLAK--HS 550

  Fly   484 KAIIQLNNELSSGEITCHL----------------------NQSVYILEVSTLQMAVLMLFNRHE 526
            ...:.|.:.:.|.::....                      |...:||:|||.||.:|||||..|
Zfish   551 GRQLTLQHHMGSADLNATFYGPIKKEDGSDVGVGGALLTGSNTRKHILQVSTFQMTILMLFNNRE 615

  Fly   527 RFTEQELVTALGVELETLQEALKQI-----------KFLVYIEVNKVNYIEINMDFTNRKRRLFC 580
            :||.:|:.....:....|..||:.:           |.....|:...:...:|..||::..|:..
Zfish   616 KFTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGHVFTVNDQFTSKLHRVKI 680

  Fly   581 NEPLPRKMRKIEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVS 643
            .....::.....|:.|...|:..|:  :::||||||||.:|:::::.|::.|.::|:.|..|...
Zfish   681 QTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLPSPV 745

  Fly   644 FIKKRLDYLVEREYLER---DNYYNIYRYL 670
            .||||::.|:|||||.|   |.  .:|.|:
Zfish   746 VIKKRIEGLIEREYLARTPEDR--KVYTYV 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	162/788 (21%)
cul3a	NP_955985.2	Cullin	40..671	CDD:459983	132/698 (19%)
		Cullin_Nedd8	704..766	CDD:463146	26/61 (43%)