Protein Alignment Cul6 and cul1a

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_955953.2
• Gene: cul1a / 323883
• ZFINID: ZDB-GENE-030131-2603
• Length: 777
• Species: Danio rerio
• Alignment Length: 784
• Identity: 205/784 - (26%)
• Similarity: 352/784 - (44%)
• Gaps: 162/784 - (20%)

  Fly    25 VNQIFDD--------YT--SFDGQKLMHLYHLIYKQCAAERNWN----------NPAQKN----- 64
            ::||:||        ||  |....:.|.||..:|..|.:....|          .|::|.
Zfish    17 LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQVRGGGPAPSKPSKKTPTPGG 81

  Fly    65 ----GRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFN 125
                |..||..|.:.|...|.|:....|:.:|::    ::..|.:.|..|:.|.:.||..|.:.|
Zfish    82 AQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDES----VLKFYTQQWEDYRFSSKVLNGICAYLN 142

  Fly   126 RNWVERERLKGDKETYPIYRLAMISWKELVFEP---SVT--ILAAI-----------RLI----- 169
            |:||.||..:|.|..|.||.||:::|:|.:|.|   .||  :|..|           |||
Zfish   143 RHWVRRECDEGRKGIYEIYSLALVTWRECLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQ 207

  Fly   170 ---------------------------------------------LSQMP-REYNKSLEYQVYQV 188
                                                         |.|.| .||.|..|.::.:.
Zfish   208 SYVELGLNEDDAFAKGPTLSVYKEYFETQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEE 272

  Fly   189 LQSIVELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAM 253
             |..|::|.::..|| .|..:.:::..||.::.:.:    |||.::.::..:|......    .:
Zfish   273 -QRRVQVYLHESTQD-ELARKCEQVLIEKHLEIFHT----EFQNLLDADKNEDLGRMYN----LV 327

  Fly   254 PEIENGT-QFKAILKRY-----LAA--RLQETRLSG-KDYIQAFLGLCR---GPLQRALRDHTKL 306
            ..|.:|. :.|.:|:.:     |||  :..|:.|:. |.|:|..|.:.:   ..:..|..:....
Zfish   328 SRITDGLGELKKLLETHIYNQGLAAIEKCGESALNDPKMYVQTILDVHKKYNALVMSAFNNDAGF 392

  Fly   307 AEVVDAVCKEEINRKG--QIIDPT----RLLVTYANELMTKRQES-EEA-IIDELKRIVKCVEFL 363
            ...:|..|...||...  :::..:    .||..|.:.|:.|..:: ||| :.|.|.:::...:::
Zfish   393 VAALDKACGRFINNNAVTKMVQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYI 457

  Fly   364 SDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEF 428
            .|:..|...|.|.|..|.:::.|.||..|:.|.|.|.:......|..:....:|:...:.|.::|
Zfish   458 EDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQF 522

  Fly   429 QDHL-NSKGIKLGFDFRPKCFKNDGSF---ENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQL 489
            :.|| ||:.:.|.|..:   ..:.||:   ::....||.||:::::.|..||.:|....|  :..
Zfish   523 KKHLTNSEPLDLDFSIQ---VLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRK--LTW 582

  Fly   490 NNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALK---QI 551
            ...||.||:..:..::.|.|:.||.|||:|:.:|..:.:|.|:|..:..::::.|.:.|:   :.
Zfish   583 LYHLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDVYTVQQLTDSTQIKIDILVQVLQILLKS 647

  Fly   552 KFLVYIEVN-KVNYIEINMD--------FTNRKRRLFCNEPLPRKMRKIEEKSEIEL---KIRRD 604
            |.||..:.| .|:.:|...|        :.|:|.|:..|.|:     |.|:|.|.|.   .|..|
Zfish   648 KLLVLEDENANVDEVEFKPDTLIKLFLGYKNKKLRVNINVPM-----KTEQKQEQETTHKNIEED 707

  Fly   605 KQ--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLER-DNYYNI 666
            ::  :.||||||||.:|.|::.:|::.|..:|..|.||:|..|||.:|.|:|:||||| |...:.
Zfish   708 RKLLIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDT 772

  Fly   667 YRYL 670
            |.||
Zfish   773 YSYL 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	203/782 (26%)
cul1a	NP_955953.2	Cullin	21..661	CDD:459983	157/658 (24%)
		Cullin_Nedd8	707..769	CDD:463146	30/61 (49%)