Protein Alignment Cul6 and Cul3

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001100393.2
• Gene: Cul3 / 301555
• RGDID: 1308190
• Length: 768
• Species: Rattus norvegicus
• Alignment Length: 802
• Identity: 175/802 - (21%)
• Similarity: 295/802 - (36%)
• Gaps: 204/802 - (25%)

  Fly    10 YFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSD 74
            |.:|:..|:.|.:|.:.:..:...||:     .||...|...         ..|:|..||..|.:
  Rat    29 YVNSIWDLLKNAIQEIQRKNNSGLSFE-----ELYRNAYTMV---------LHKHGEKLYTGLRE 79

  Fly    75 CLMKRLKN-IAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDK 138
            .:.:.|.| :...:.|.|::|    .:....:.|..:|.:...:.....:.:|.:|::..::.
  Rat    80 VVTEHLINKVREDVLNSLNNN----FLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVEN-- 138

  Fly   139 ETYPIYRLAMISWKELVF---------------------EPSVTILAAIR------LILS----- 171
                :|.|.:|.:::.|.                     :..|....|||      :||.
  Rat   139 ----VYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRS 199

  Fly   172 -----------QMPREY-----NKSLEYQVYQVLQSIVELYANDKYQDVSLPSRIDKIFTEKVMD 220
                       :|..|:     .|.|......|....||...|::.:.|.  ..:||...|.::.
  Rat   200 VYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVM--HCLDKSTEEPIVK 262

  Fly   221 FYKSTTLHEFQKIVVSNDYKDFKHFLR------YACL--AMPEIENGTQFKAILKRYLAARLQET 277
            ..:...:.:..|.:|..:.....|.|:      .||:  ....:.||      ||..........
  Rat   263 VVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNG------LKTMCECMSSYL 321

  Fly   278 RLSGK-------------DYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEINRKGQIIDPTR 329
            |..||             ||||..|.| :....|.|::...    .|.:.|:.|  .|..
  Rat   322 REQGKALVSEEGEGKNPVDYIQGLLDL-KSRFDRFLQESFN----NDRLFKQTI--AGDF----- 374

  Fly   330 LLVTYANELMTKRQESEEAIIDE-LKRIVK----------------CVEFLSDEYKFIDMYLKAL 377
               .|...|.::..|.....||: ||:.||                ...|:.::..|...|.:.|
  Rat   375 ---EYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHL 436

  Fly   378 RIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIKL-GF 441
            ..|.:...|.||..|..|.|.|..:.....|..:....||:....|...||:.||.:.|:.| |.
  Rat   437 ARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGV 501

  Fly   442 DF---------------RPKCFKNDGSFENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNN 491
            |.               .|||            .:|...:.|::.||.||.|:  .|...:.|.:
  Rat   502 DLTVRVLTTGYWPTQSATPKC------------NIPPAPRHAFEIFRRFYLAK--HSGRQLTLQH 552

  Fly   492 ELSSGEITCHL----------------------NQSVYILEVSTLQMAVLMLFNRHERFTEQELV 534
            .:.|.::....                      |...:||:|||.||.:|||||..|::|.:|:.
  Rat   553 HMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQ 617

  Fly   535 TALGVELETLQEALKQI-----------KFLVYIEVNKVNYIEINMDFTNRKRRLFCNEPLPRKM 588
            ....:....|..||:.:           |.....|:...:...:|..||::..|:.......::.
  Rat   618 QETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGHIFTVNDQFTSKLHRVKIQTVAAKQG 682

  Fly   589 RKIEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDY 651
            ....|:.|...|:..|:  :::||||||||.:|:::::.|::.|.::||.|..|....||||::.
  Rat   683 ESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEG 747

  Fly   652 LVEREYLER---DNYYNIYRYL 670
            |:|||||.|   |.  .:|.|:
  Rat   748 LIEREYLARTPEDR--KVYTYV 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	169/785 (22%)
Cul3	NP_001100393.2	Interaction with KLHL18. /evidence=ECO:0000250|UniProtKB:Q13618	2..41		4/11 (36%)
		Cullin	34..665	CDD:459983	137/691 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..698		3/20 (15%)
		Cullin_Nedd8	698..760	CDD:463146	27/61 (44%)