Protein Alignment Cul6 and Cul1

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_036172.1
• Gene: Cul1 / 26965
• MGIID: 1349658
• Length: 776
• Species: Mus musculus
• Alignment Length: 783
• Identity: 204/783 - (26%)
• Similarity: 348/783 - (44%)
• Gaps: 161/783 - (20%)

  Fly    25 VNQIFDD--------YT--SFDGQKLMHLYHLIYKQCAAERNWNN------PAQKN--------- 64
            ::||:||        ||  |....:.|.||..:|..|.:....|.      |..|:
Mouse    17 LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGA 81

  Fly    65 ---GRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNR 126
               |..||..|.:.|...|.|:....|:.:|::    ::..|.:.|..|:.|.:.||..|.:.||
Mouse    82 QFVGLELYKRLKEFLKNYLTNLLKDGEDLMDES----VLKFYTQQWEDYRFSSKVLNGICAYLNR 142

  Fly   127 NWVERERLKGDKETYPIYRLAMISWKELVFEP---SVT--ILAAI-----------RLI------ 169
            :||.||..:|.|..|.||.||:::|::.:|.|   .||  :|..|           |||
Mouse   143 HWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQS 207

  Fly   170 --------------------------------------------LSQMP-REYNKSLEYQVYQVL 189
                                                        |.|.| .||.|..|.::.:.
Mouse   208 YVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEE- 271

  Fly   190 QSIVELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMP 254
            |..|::|.::..|| .|..:.:::..||.::.:.:    |||.::.::..:|......    .:.
Mouse   272 QRRVQVYLHESTQD-ELARKCEQVLIEKHLEIFHT----EFQNLLDADKNEDLGRMYN----LVS 327

  Fly   255 EIENGT-QFKAILKRY-----LAA--RLQETRLSG-KDYIQAFLGLCR---GPLQRALRDHTKLA 307
            .|::|. :.|.:|:.:     |||  :..|..|:. |.|:|..|.:.:   ..:..|..:.....
Mouse   328 RIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFV 392

  Fly   308 EVVDAVCKEEINRKG------QIIDPTRLLVTYANELMTKRQES-EEA-IIDELKRIVKCVEFLS 364
            ..:|..|...||...      .......||..|.:.|:.|..:: ||| :.|.|.:::...:::.
Mouse   393 AALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIE 457

  Fly   365 DEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQ 429
            |:..|...|.|.|..|.:::.|.||..|:.|.|.|.:......|..:....:|:...:.|.::|:
Mouse   458 DKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFK 522

  Fly   430 DHL-NSKGIKLGFDFRPKCFKNDGSF---ENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLN 490
            .|| ||:.:.|.|..:   ..:.||:   ::....||.||:::::.|..||.:|....|  :...
Mouse   523 KHLTNSEPLDLDFSIQ---VLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRK--LTWL 582

  Fly   491 NELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALK---QIK 552
            .:||.||:..:..::.|.|:.||.|||:|:.:|..:.:|.|:|..:..::::.|.:.|:   :.|
Mouse   583 YQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSK 647

  Fly   553 FLVYIEVN-KVNYIEINMD--------FTNRKRRLFCNEPLPRKMRKIEEKSEIEL---KIRRDK 605
            .||..:.| .|:.:|:..|        :.|:|.|:..|.|:     |.|:|.|.|.   .|..|:
Mouse   648 LLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPM-----KTEQKQEQETTHKNIEEDR 707

  Fly   606 Q--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLER-DNYYNIY 667
            :  :.||||||||.:|.|::.:|:..|..:|..|.||:|..|||.:|.|:|:||||| |...:.|
Mouse   708 KLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTY 772

  Fly   668 RYL 670
            .||
Mouse   773 SYL 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	202/781 (26%)
Cul1	NP_036172.1	Cullin	21..660	CDD:459983	156/657 (24%)
		Cullin_Nedd8	706..768	CDD:463146	30/61 (49%)