Protein Alignment Cul6 and Cul3

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_057925.1
• Gene: Cul3 / 26554
• MGIID: 1347360
• Length: 768
• Species: Mus musculus
• Alignment Length: 797
• Identity: 175/797 - (21%)
• Similarity: 298/797 - (37%)
• Gaps: 194/797 - (24%)

  Fly    10 YFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSD 74
            |.:|:..|:.|.:|.:.:..:...||:     .||...|...         ..|:|..||..|.:
Mouse    29 YVNSIWDLLKNAIQEIQRKNNSGLSFE-----ELYRNAYTMV---------LHKHGEKLYTGLRE 79

  Fly    75 CLMKRLKN-IAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDK 138
            .:.:.|.| :...:.|.|::|    .:....:.|..:|.:...:.....:.:|.:|::..::.
Mouse    80 VVTEHLINKVREDVLNSLNNN----FLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVEN-- 138

  Fly   139 ETYPIYRLAMISWKELVF---------------------EPSVTILAAIR------LILS----- 171
                :|.|.:|.:::.|.                     :..|....|||      :||.
Mouse   139 ----VYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRS 199

  Fly   172 -----------QMPREY-----NKSLEYQVYQVLQSIVELYANDKYQDVSLPSRIDKIFTEKVMD 220
                       :|..|:     .|.|......|....||...|::.:.|.  ..:||...|.::.
Mouse   200 VYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVM--HCLDKSTEEPIVK 262

  Fly   221 FYKSTTLHEFQKIVVSNDYKDFKHFLR------YACL--AMPEIENGTQ-----FKAILKRYLAA 272
            ..:...:.:..|.:|..:.....|.|:      .||:  ....:.||.:     ....|:....|
Mouse   263 VVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSCYLREQGKA 327

  Fly   273 RLQETRLSGK---DYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEINRKGQIIDPTRLLVTY 334
            .:.|.. .||   ||||..|.| :....|.|::...    .|.:.|:.|  .|..        .|
Mouse   328 LVSEEG-EGKNPVDYIQGLLDL-KSRFDRFLQESFN----NDRLFKQTI--AGDF--------EY 376

  Fly   335 ANELMTKRQESEEAIIDE-LKRIVK----------------CVEFLSDEYKFIDMYLKALRIRQI 382
            ...|.::..|.....||: ||:.||                ...|:.::..|...|.:.|..|.:
Mouse   377 FLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLL 441

  Fly   383 NETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIKL-GFDF--- 443
            ...|.||..|..|.|.|..:.....|..:....||:....|...||:.||.:.|:.| |.|.
Mouse   442 TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVR 506

  Fly   444 ------------RPKCFKNDGSFENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSG 496
                        .|||            .:|...:.|::.||.||.|:  .|...:.|.:.:.|.
Mouse   507 VLTTGYWPTQSATPKC------------NIPPAPRHAFEIFRRFYLAK--HSGRQLTLQHHMGSA 557

  Fly   497 EITCHL----------------------NQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGV 539
            ::....                      |...:||:|||.||.:|||||..|::|.:|:.....:
Mouse   558 DLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDI 622

  Fly   540 ELETLQEALKQI-----------KFLVYIEVNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEE 593
            ....|..||:.:           |.....|:...:...:|..||::..|:.......::.....|
Mouse   623 PERELVRALQSLACGKPTQRVLTKEPKSKEIESGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPE 687

  Fly   594 KSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVERE 656
            :.|...|:..|:  :::||||||||.:|:::::.|::.|.::||.|..|....||||::.|:|||
Mouse   688 RKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIERE 752

  Fly   657 YLER---DNYYNIYRYL 670
            ||.|   |.  .:|.|:
Mouse   753 YLARTPEDR--KVYTYV 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	169/780 (22%)
Cul3	NP_057925.1	Interaction with KLHL18. /evidence=ECO:0000250|UniProtKB:Q13618	2..41		4/11 (36%)
		Cullin	34..665	CDD:459983	137/686 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..698		3/20 (15%)
		Cullin_Nedd8	698..760	CDD:463146	27/61 (44%)