Protein Alignment Cul6 and cul4

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_594195.1
• Gene: cul4 / 2543116
• PomBaseID: SPAC3A11.08
• Length: 734
• Species: Schizosaccharomyces pombe
• Alignment Length: 757
• Identity: 164/757 - (21%)
• Similarity: 303/757 - (40%)
• Gaps: 170/757 - (22%)

  Fly     1 MNRVKRISNYFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNG 65
            :.|..:.|..|:.:...:.:.:|::....:.:...:|.:.......:...|     ||...::
pombe    60 LTRADQASRCFNILQHHMSSGIQLLKDSAESFIQLEGTETDTNACTVVVGC-----WNKWLER-- 117

  Fly    66 RSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVE 130
                       ::.::||.:.|:.            .:|.|...|. :.|:|:|:.:
pombe   118 -----------VEIVQNIFYYMDK------------TFLSHHPDYP-TIEELSLSLF-------- 150

  Fly   131 RERLKGDKE-TYPIYRLAMISWKELVFEPSV--TILAAIRLILSQMPREYNKSLEYQVYQVLQSI 192
            ||:|...|. ..|.....:.|::.|....|.  ..|....|:|.:  .|...|:...:|.|:.|
pombe   151 REKLMAVKNIQIPFLNSLLQSFENLHSSKSTDHAYLQDAMLMLHR--TEMYSSVFVPMYLVMLS- 212

  Fly   193 VELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLHE---FQKIVVSNDYKDFKHFLRYACLAMP 254
                   ::.|.....:|.::..|:.:::..|:...|   .:|..:..|.|..:..:: .||...
pombe   213 -------RFYDTESSQKIQELPLEEYLEYAMSSLEREDAYVEKFDIVRDKKSIRETVQ-RCLITS 269

  Fly   255 EIENGT----QFKAILKR------YLAARLQ---ETRL--------------------SGKDYIQ 286
            .::..|    ||  |.||      .|.|.||   ||..                    |..|.:
pombe   270 HLDTLTKGISQF--IEKRDAHSCKLLYALLQFNHETEYLIQPWSDCLVDVGFKLVNDESKDDTL- 331

  Fly   287 AFLGLCRGPLQRALRDHTKLAEVVD-AVCKEE-------------IN-RKG-QIIDPTRLLVTYA 335
                     :|..|..|..|..||| :...:|             || .|| |...|.||:..|.
pombe   332 ---------VQELLSFHKFLQVVVDESFLHDETLSYAMRKAFETFINGAKGSQREAPARLIAKYI 387

  Fly   336 NELMTKRQESE--EAIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSL 398
            :.|:...:::.  :.:.:....|:....:::.:..|...|...:..|.:...|.|...|.::..:
pombe   388 DYLLRVGEQASGGKPLKEVFSEILDLFRYIASKDIFEAYYKLDIAKRLLLNKSASAQNELMLLDM 452

  Fly   399 LNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIKLGFDFRPKCFKND------GSFENF 457
            |.|...:..|..:....|||:    :.|||.......  |...:.....:.|.      .|:...
pombe   453 LKKTCGSQFTHSLEGMFRDVN----ISKEFTSSFRHS--KAAHNLHRDLYVNVLSQAYWPSYPES 511

  Fly   458 NLTLPDELQQAWKEFRIFYEARKLQSK---------AIIQLNNELSSGEITCHLNQSVYILEVST 513
            ::.|||::||....|..||.::::..|         .|::....|.:.|           |.:|.
pombe   512 HIRLPDDMQQDLDCFEKFYLSKQVGKKISWYASLGHCIVKARFPLGNKE-----------LSISL 565

  Fly   514 LQMAVLMLFNR---HERFTEQEL--VTALG-VEL-ETLQE-ALKQIKFLVYIEVNKV----NYIE 566
            .|..||:.||.   .|..:.|:|  .|.|. ::| .|||. :..:|:.||.:..:|.    ....
pombe   566 FQACVLLQFNNCLGGEGISYQDLKKSTELSDIDLTRTLQSLSCARIRPLVMVPKSKKPSPDTMFY 630

  Fly   567 INMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKIRRDKQ--VDAAIVRIMKGQKQLEYSELISL 629
            :|..||::..|:..|:...::.|  :|.|:::.::.||:|  :.|:|||:||.::::::.:|:..
pombe   631 VNEKFTDKLYRVKINQIYLKEER--QENSDVQEQVVRDRQFELQASIVRVMKQKEKMKHDDLVQY 693

  Fly   630 VYEELKDRVKPQVSFIKKRLDYLVEREYLER-DNYYNIYRYL 670
            |...:|||..|.||.:|..::.|:|:||||| ||  :||.|:
pombe   694 VINNVKDRGIPLVSDVKTAIEKLLEKEYLEREDN--DIYTYV 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	159/731 (22%)
cul4	NP_594195.1	COG5647	1..734	CDD:227934	164/757 (22%)