Protein Alignment Cul6 and cul1

DIOPT Version :9

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_594259.1
• Gene: cul1 / 2542393
• PomBaseID: SPAC17G6.12
• Length: 767
• Species: Schizosaccharomyces pombe
• Alignment Length: 786
• Identity: 191/786 - (24%)
• Similarity: 325/786 - (41%)
• Gaps: 166/786 - (21%)

  Fly    11 FDSMLPLIDNILQVVNQIFDDYTSFDGQ---KLMHLYHLIYKQCA-AER-----NWNN-PAQKNG 65
            :||:....|.:...|:|||:...  :|.   |.|.||..|:..|| |.:     |:|: .|...|
pombe    17 YDSLNGTWDFLKTGVSQIFERLD--EGMTITKYMELYTAIHNYCADASKTITVDNFNDQTANVLG 79

  Fly    66 RSLY---IVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRN 127
            .:||   ::..:..:.||:.......|..:.      :|.|.::|..:..|...:|....:.||.
pombe    80 EALYNNLVLYLEEYLARLRKECISQTNHEEQ------LAAYAKYWTRFTTSARFINHLFGYLNRY 138

  Fly   128 WVERERLKGDKETYPIYRLAMISW---------------------KELVFEP-----------SV 160
            ||:.:....:...|.||.|.::||                     |:.::||           |:
pombe   139 WVKLKNRFTETLVYDIYTLCLVSWHHHVFSHIRDSLLQNLLYMFTKKRLYEPTDMKYVEVCVDSI 203

  Fly   161 TILA---------------------------------AIRLILSQMPREYNKSLEYQVYQVLQSI 192
            |.|:                                 :...:.|....:|.|..|.::.:. :.:
pombe   204 TSLSFDKTDMTKPNLSSYKTFFETNFIENTKNFYAKESSEYLASHSITDYLKKAEIRLAEE-EEL 267

  Fly   193 VELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLH-EFQKIVVSNDYKDFKHFLRYACLAMPEI 256
            |.||.::......|.:      ||.|:.......|| :|.:::..|..:|.....|    .|...
pombe   268 VRLYLHESTLKPLLEA------TEDVLIAQHEEVLHNDFARMLDQNCSEDIIRMYR----LMSRT 322

  Fly   257 ENGTQ-----FKAILKRYLAARLQ--------ETRLSGKDYIQAFLGLCRGP---LQRALRDHTK 305
            .||.|     |:..:||...|.:.        |..:..|:|::..|...:..   :..|....|.
pombe   323 PNGLQPLRQTFEEFVKRSGFAAVAKIVPQVGGEADVDPKEYMEMLLSTYKASKELVNTAFHGDTD 387

  Fly   306 LAEVVDAVCKEEINR-----KGQIIDPTRLLVTYANELMTKRQESEEA--IIDELKRIVKCVEFL 363
            ..:.:|...:|.:||     :.....| .||..||:.::.|..::.:.  :.|.|..|:....::
pombe   388 FTKSLDTAFRELVNRNVVCQRSSSRSP-ELLAKYADSILRKSNKNVDIDDVEDCLSSIIIIFRYV 451

  Fly   364 SDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANF-VTRCIYVQLRDVDKLRTLKKE 427
            .|:..|.:.|.|.|..|.:|.||.|...||.|.|.| |::..| .|..:....:|:...:.:.:.
pombe   452 EDKDVFQNFYTKLLAKRLVNGTSNSQDAESSMLSKL-KEVCGFEYTSKLQRMFQDISLSQEITEA 515

  Fly   428 F-------QDHLNSKGIKLGFDFRPKCFKNDGSFENFNLTLPDELQQAWKEFRIFY----EARKL 481
            |       ..:::...:.||..|.|.      |..|.|..||:||...::.|:.:|    ..|||
pombe   516 FWQLPQSRAGNIDFSALVLGTSFWPL------SPNNVNFHLPEELVPLYEGFQNYYYSCHNGRKL 574

  Fly   482 QSKAIIQLNNELSSGEITCHLNQS---VYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELET 543
            ....      .||.|||...:|..   .|:.:|||.||.||:|:|..:.:|.:||....|:..:.
pombe   575 SWLF------HLSKGEIKARINPQTNVTYVFQVSTYQMGVLLLYNHRDSYTYEELAKITGLSTDF 633

  Fly   544 LQEALK---QIKFLVYIEVNKV----NYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKI 601
            |...|.   :.|.|:..:.:|:    :..:||.:|..:|.|:..|  ||.:..:.:|..|....|
pombe   634 LTGILNIFLKAKVLLLGDNDKLGDPNSTYKINENFRMKKIRVQLN--LPIRSEQKQESLETHKTI 696

  Fly   602 RRDKQ--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLE---RD 661
            ..|::  :.:|||||||.::.|::..|:....:::|.|..|:||.||:.:|.|:|:||||   ||
pombe   697 EEDRKLLLQSAIVRIMKARRTLKHVVLVKETIDQIKSRFTPKVSDIKQCIDMLIEKEYLERQGRD 761

  Fly   662 NYYNIY 667
            .|  ||
pombe   762 EY--IY 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	188/772 (24%)
cul1	NP_594259.1	COG5647	1..767	CDD:227934	191/786 (24%)