Protein Alignment Cul6 and cul-2

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001023008.1
• Gene: cul-2 / 176806
• WormBaseID: WBGene00000837
• Length: 791
• Species: Caenorhabditis elegans
• Alignment Length: 797
• Identity: 162/797 - (20%)
• Similarity: 313/797 - (39%)
• Gaps: 171/797 - (21%)

  Fly    11 FDSM-LPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSD 74
            ||.: :.|..:|:.::|     .......:..|.:..:|..|.     :.|...:.| ||..:..
 Worm    28 FDKVWVQLRPSIIDIIN-----LRPITNVQWHHKFSDVYDICV-----SIPTPLSER-LYNEVKA 81

  Fly    75 CLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKE 139
            |:.:.::.    ....:.|..|..|:.:|.:.|..:......::....:.|:.:|:::|.. |.:
 Worm    82 CIQEHVRQ----KRQDIVDVDPDLLLQEYHKMWRVFHEGAIFIHRLFGYLNKQFVKQKRCT-DLD 141

  Fly   140 TYPIYR-------------LAMISWKELVFEPSVTILAAIRLILSQMPREYN-KSLEYQVYQVLQ 190
            .:..|.             ||:..|||.:.:..:..|..:.||.....|:.| ..:..:|..|:.
 Worm   142 NFAQYAAFLQIPDVKEIGCLALEIWKEDLVKTILPQLVKLLLIAIDNDRKGNFPHIANEVSGVIN 206

  Fly   191 SIVELYAND---------KYQ----------------------------------DVSL------ 206
            |.|::...|         :|:                                  |:|.
 Worm   207 SFVKMEETDFDVVPAEGARYKARESTTAFYQESFEKPLLTDTEQYYSALAQKMLTDLSCSEYMEQ 271

  Fly   207 -----------------PSRIDKIFT--EKVMDFYKSTTLHEF-QKIVVSNDYKDFKHFLRYACL 251
                             .|.::|:.|  :|||.......||.. ..::.:.:.||.::..|   |
 Worm   272 VIVLLEQEEMRAKKYLHESSVEKVITLCQKVMIKAHKDKLHAVCHDLITNEENKDLRNMYR---L 333

  Fly   252 AMPEIENG-----TQFKA-ILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRALRDHTKLAEVV 310
            ..| |:.|     .:|:. :.|:.|.|   .:||:|::..|.|       ::..||.:.|..::.
 Worm   334 LKP-IQAGLSVMVKEFEEYVKKKGLEA---VSRLTGENVPQQF-------VENVLRVYNKFNDMK 387

  Fly   311 DAVCKEE--------------INRK--GQII-DPTRLLVTYANELMTKRQE--SEEAIIDELKRI 356
            .||..::              :|.|  ||.: ..:..|..|.:.|:.|..:  ||..:..:|...
 Worm   388 TAVFMDDGEFSSGLDKALQGVVNSKEPGQSVPKASERLARYTDGLLKKSTKGLSETDLEAKLDSA 452

  Fly   357 VKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKL 421
            :....::.|:..|...|.|.|..|.|..||.|...|.:|.:.|.:......|..:.....|:...
 Worm   453 IVIFRYIEDKDIFQKFYSKMLANRLIASTSISMDAEELMINKLKQACGYEFTSKLSRMFTDIGLS 517

  Fly   422 RTLKKEFQDHL-NSKGIKLGFDFRP-------------------KCFKNDGSFENFNLTLPDELQ 466
            :.|...|..|: :.|.::....|.|                   ....|..:.:..|..||..||
 Worm   518 QELSNNFDKHIADIKTVQPDVKFVPTQTMILQAGSWPLNAPQLSTNSNNQTAQDVANFHLPRILQ 582

  Fly   467 QAWKEFRIFYEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQ 531
            ...:||..||.. |...:.:..|.| :|.|::........|:.::...|||.|:.|.|.:....:
 Worm   583 PVIQEFEKFYTG-KHNGRKLTWLFN-MSQGDVRLTYLDKQYVAQMYVYQMAALLCFERRDAILVK 645

  Fly   532 ELVTALGVELETLQEALKQIKFLVYIEVNKVN-----YIEINMDFTNRKRRLFCNEPLPRKMRKI 591
            ::...:||..:.|.:.::.|..:..:..:..|     .:.:||..|:::.:.....|...|  .:
 Worm   646 DIGEEIGVSGDYLLKTIRTILDVTLLTCDDQNLTADSLVRLNMSMTSKRMKFRLQAPQVNK--AV 708

  Fly   592 EEKSE-IELKIRRDKQ--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLV 653
            |::.| :...:.:|::  ::.|||||||.:|.|:::.|::.:.::.|.|..|.|.||||.::.|:
 Worm   709 EKEQEAVANTVSQDRKYYMECAIVRIMKTRKVLKHNALVTEIMDQTKGRFSPDVPFIKKSIEDLI 773

  Fly   654 EREYLERDNYYNIYRYL 670
            |:.|::|.:..:.|:||
 Worm   774 EKMYIQRTDQNDEYQYL 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	156/780 (20%)
cul-2	NP_001023008.1	Cullin	32..662	CDD:459983	125/661 (19%)
		Cullin_Nedd8	722..784	CDD:463146	23/61 (38%)