Protein Alignment Cul6 and cul-1

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_499309.1
• Gene: cul-1 / 176466
• WormBaseID: WBGene00000836
• Length: 780
• Species: Caenorhabditis elegans
• Alignment Length: 694
• Identity: 153/694 - (22%)
• Similarity: 284/694 - (40%)
• Gaps: 147/694 - (21%)

  Fly    99 LIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAMISWKELVFE--PSVT 161
            |:..|...|..::.|.:.::....:.||:|:.||..:|.:..|.:|.||::.||..:|.  ....
 Worm   111 LLKYYTTEWENFRISSKVMDGIFAYLNRHWIRRELDEGHENIYMVYTLALVVWKRNLFNDLKDKV 175

  Fly   162 ILAAIRLILSQMPREYNKSLEYQVYQVLQSIVELYANDKYQDVSLPSRIDKI----------FTE 216
            |.|.:.||.|:.......| .| :..|::.:|||..:|...|....:...|:          |.|
 Worm   176 IDAMLELIRSERTGSMINS-RY-ISGVVECLVELGVDDSETDAKKDAETKKLAVYKEFFEVKFLE 238

  Fly   217 KVMDFYK--------------------STTLHE--------------------FQKIVVSNDYKD 241
            ....||.                    .|.|::                    .:.:::||.. |
 Worm   239 ATRGFYTQEAANFLSNGGNVTDYMIKVETRLNQEDDRCQLYLNSSTKTPLATCCESVLISNQL-D 302

  Fly   242 F--KHF--------------LRYACLAMPEIENG-TQFKAILKRYLAAR--------LQETRLSG 281
            |  :||              :...|..:|   || .:.:..|:.::|..        ..|.....
 Worm   303 FLQRHFGGLLVDKRDDDLSRMFKLCDRVP---NGLDELRKSLENHIAKEGHQALERVAMEAATDA 364

  Fly   282 KDYIQAFLGL---CRGPLQRALRDHTKLAEVVDAVCKEEINR---------KGQIIDPTRLLVTY 334
            |.|::..|.:   .:..:.|:.::.....:.:|......||.         :.|:.....||..|
 Worm   365 KLYVKTLLEVHERYQSLVNRSFKNEPGFMQSLDKAATSFINNNAVTKRAPPQAQLTKSAELLARY 429

  Fly   335 ANELMTKRQE-SEEAIIDELK-RIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYS 397
            .::|:.|..: .:||.::||: :|:...:::.|:..|...|.|....|.|:|.|.||..|
 Worm   430 CDQLLRKSSKMPDEAELEELQTKIMVVFKYIDDKDVFSKFYTKMFSKRLISELSASDEAE----- 489

  Fly   398 LLNKKMANFVTR----CIY-------VQLRDVDKLRTLKKEFQ----DHLNSKGIKLGFDFRPKC 447
                  |||:|:    |.|       ..:.|....:.|..:|:    |.|..|.::...     .
 Worm   490 ------ANFITKLKSMCGYEYTARLSKMVNDTQVSKDLTADFKEKKADMLGQKSVEFNV-----L 543

  Fly   448 FKNDGSFENF---NLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEITCHLNQSVYIL 509
            ..:.||:..|   .:|||.:|.:..:.|..||. .|...:.:..:.:: |.||||.......|:.
 Worm   544 VLSSGSWPTFPTTPITLPQQLSKTIEIFGQFYN-EKFNGRRLTWVYSQ-SRGEITSTAFPKKYVF 606

  Fly   510 EVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEAL-KQIKFLVY---------IEVNKVNY 564
            ..:|.||..::|||..:.:|.:::..|..::.::....: ..||.||.         .||.....
 Worm   607 TATTAQMCTMLLFNEQDSYTVEQIAAATKMDEKSAPAIVGSLIKNLVLKADTELQKEDEVPMTAT 671

  Fly   565 IEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKIRRDKQ--VDAAIVRIMKGQKQLEYSELI 627
            :.:|..:.|:|.|:..:: ...|...:.:...::..:..|::  :.|.||||||.:|::::.:|:
 Worm   672 VSLNKAYMNKKVRVDLSK-FTMKQDAVRDTENVQKNVEEDRKSVISACIVRIMKTRKRVQHQQLM 735

  Fly   628 SLVYEELKDRVKPQVSFIKKRLDYLVEREYLER-DNYYNIYRYL 670
            :.|..:|..|.||:|..||:.:..|:|:||:.| :...::|.||
 Worm   736 TEVITQLSGRFKPKVEMIKRCIGSLIEKEYMLRTEGQKDLYEYL 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	151/692 (22%)
cul-1	NP_499309.1	Cullin	17..678	CDD:459983	123/590 (21%)
		Cullin_Nedd8	710..772	CDD:463146	23/61 (38%)