Protein Alignment Cul6 and cul4b

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: XP_017951653.1
• Gene: cul4b / 100151714
• XenbaseID: XB-GENE-963628
• Length: 865
• Species: Xenopus tropicalis
• Alignment Length: 744
• Identity: 162/744 - (21%)
• Similarity: 301/744 - (40%)
• Gaps: 151/744 - (20%)

  Fly    30 DDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRLKNI------AWVME 88
            ::||....|||......|....:.:.|.....|.........:|..|.|:|:.|      |.:.:
 Frog   162 ENYTDETWQKLKGAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQ 226

  Fly    89 NQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAMISWKE 153
            .:.|....:..:.|..:.|..:.|....:.......:|.:|.:..:...     |:.:.:..::.
 Frog   227 FREDALDSVLFLKKIDKCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPS-----IWDMGLELFRN 286

  Fly   154 LVFEPSVTILAAIRLILSQMPREYN-----KSLEYQVYQVLQSIVELYAN-DKYQDVSLPSRIDK 212
            .:..........|..||..:.||.|     :||       |:|::.:.:: ..|||     ..::
 Frog   287 HIISDQKVQNKTIDGILLLIERERNGEAIDRSL-------LRSLLSMLSDLQIYQD-----SFEQ 339

  Fly   213 IFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFL-----RYACLAMPEIENGTQ-------FKAI 265
            .|.|:....|.:    |.|:::...:..::.|.:     ..|...:..::..||       .|.:
 Frog   340 RFLEETNRLYAA----EGQRLMQEREVPEYLHHVNKRLEEEADRVITYLDQSTQKPLIATVEKQL 400

  Fly   266 LKRYLAARLQ--------ETRLSGKDYIQAFLGLCRGPLQRAL-------------------RDH 303
            |..:|.|.||        |.|:.....:.......||.:|..|                   :|.
 Frog   401 LGEHLTATLQKGLNHLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDK 465

  Fly   304 TKLAEVVD---------AVC--KEE-------------INRKGQIIDPTRLLVTYANELMTKRQE 344
            |.:.|::|         .||  |.|             ||::..  .|..|:..|.:..:  |..
 Frog   466 TMVQELLDFKDKVDHVIDVCFLKNEKFVNAMKEAFETFINKRPN--KPAELIAKYVDSKL--RTG 526

  Fly   345 SEEAIIDELKRIVKCV----EFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMAN 405
            ::||..:||::::..:    .|:..:..|...|.|.|..|.:...|.|...|..|.|.|..:...
 Frog   527 NKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGA 591

  Fly   406 FVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIK---------LGFDFRPKCFKNDGSFENFNLTL 461
            ..|..:....:|::..:.:...|:.::.::.:.         |...:.|       ::....:.|
 Frog   592 AFTSKLEGMFKDMELSKDIMVHFKQYMQNQNVPGNIELTVNILTMGYWP-------TYVPMEVHL 649

  Fly   462 PDELQQAWKEFRIFY----EARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLF 522
            |.|:.:..:.|:.||    ..|||      |..:.|....:....|:....|:||..|..||::|
 Frog   650 PPEMVKLQEIFKTFYLGKHSGRKL------QWQSTLGQCVLKAEFNEGKKELQVSLFQTLVLLMF 708

  Fly   523 NRHERFTEQELVTALGVELETLQEALKQI-----KFLVYI----EVNKVNYIEINMDFTNRKRRL 578
            |..:.|:.:|:..|.|:|...|:..|:.:     :.||..    :|:..:....|.||.::..|:
 Frog   709 NEGDEFSLEEIRQATGIEDSELRRTLQSLACGRARVLVKSPKSKDVDDGDKFTFNDDFRHQLFRI 773

  Fly   579 FCNEPLPRKMRK-IEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKP 640
            ..|:   .:|:: :||::....::.:|:  |:|||||||||.:|.|.::.|:|.||.:||..|||
 Frog   774 RINQ---IQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKP 835

  Fly   641 QVSFIKKRLDYLVEREYLERD----NYYN 665
              :.:|||::.|::|:|:|||    |.||
 Frog   836 --ADLKKRIESLIDRDYMERDKENPNQYN 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	162/744 (22%)
cul4b	XP_017951653.1	Cullin	169..766	CDD:459983	119/634 (19%)
		Cullin_Nedd8	794..859	CDD:214883	31/66 (47%)