DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and cul4b

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	XP_017951653.1	Gene:	cul4b / 100151714	XenbaseID:	XB-GENE-963628	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	744	Identity:	162/744 - (21%)
Similarity:	301/744 - (40%)	Gaps:	151/744 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRLKNI------AWVME 88
            ::||....|||......|....:.:.|.....|.........:|..|.|:|:.|      |.:.:
Frog   162 ENYTDETWQKLKGAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQ 226

  Fly    89 NQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAMISWKE 153
            .:.|....:..:.|..:.|..:.|....:.......:|.:|.:..:...     |:.:.:..::.
Frog   227 FREDALDSVLFLKKIDKCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPS-----IWDMGLELFRN 286

  Fly   154 LVFEPSVTILAAIRLILSQMPREYN-----KSLEYQVYQVLQSIVELYAN-DKYQDVSLPSRIDK 212
            .:..........|..||..:.||.|     :||       |:|::.:.:: ..|||     ..::
Frog   287 HIISDQKVQNKTIDGILLLIERERNGEAIDRSL-------LRSLLSMLSDLQIYQD-----SFEQ 339

  Fly   213 IFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFL-----RYACLAMPEIENGTQ-------FKAI 265
            .|.|:....|.:    |.|:::...:..::.|.:     ..|...:..::..||       .|.:
Frog   340 RFLEETNRLYAA----EGQRLMQEREVPEYLHHVNKRLEEEADRVITYLDQSTQKPLIATVEKQL 400

  Fly   266 LKRYLAARLQ--------ETRLSGKDYIQAFLGLCRGPLQRAL-------------------RDH 303
            |..:|.|.||        |.|:.....:.......||.:|..|                   :|.
Frog   401 LGEHLTATLQKGLNHLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDK 465

  Fly   304 TKLAEVVD---------AVC--KEE-------------INRKGQIIDPTRLLVTYANELMTKRQE 344
            |.:.|::|         .||  |.|             ||::..  .|..|:..|.:..:  |..
Frog   466 TMVQELLDFKDKVDHVIDVCFLKNEKFVNAMKEAFETFINKRPN--KPAELIAKYVDSKL--RTG 526

  Fly   345 SEEAIIDELKRIVKCV----EFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMAN 405
            ::||..:||::::..:    .|:..:..|...|.|.|..|.:...|.|...|..|.|.|..:...
Frog   527 NKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGA 591

  Fly   406 FVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIK---------LGFDFRPKCFKNDGSFENFNLTL 461
            ..|..:....:|::..:.:...|:.::.::.:.         |...:.|       ::....:.|
Frog   592 AFTSKLEGMFKDMELSKDIMVHFKQYMQNQNVPGNIELTVNILTMGYWP-------TYVPMEVHL 649

  Fly   462 PDELQQAWKEFRIFY----EARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLF 522
            |.|:.:..:.|:.||    ..|||      |..:.|....:....|:....|:||..|..||::|
Frog   650 PPEMVKLQEIFKTFYLGKHSGRKL------QWQSTLGQCVLKAEFNEGKKELQVSLFQTLVLLMF 708

  Fly   523 NRHERFTEQELVTALGVELETLQEALKQI-----KFLVYI----EVNKVNYIEINMDFTNRKRRL 578
            |..:.|:.:|:..|.|:|...|:..|:.:     :.||..    :|:..:....|.||.::..|:
Frog   709 NEGDEFSLEEIRQATGIEDSELRRTLQSLACGRARVLVKSPKSKDVDDGDKFTFNDDFRHQLFRI 773

  Fly   579 FCNEPLPRKMRK-IEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKP 640
            ..|:   .:|:: :||::....::.:|:  |:|||||||||.:|.|.::.|:|.||.:||..|||
Frog   774 RINQ---IQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKP 835

  Fly   641 QVSFIKKRLDYLVEREYLERD----NYYN 665
              :.:|||::.|::|:|:|||    |.||
Frog   836 --ADLKKRIESLIDRDYMERDKENPNQYN 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	162/744 (22%)
		CULLIN	362..500	CDD:214545	28/150 (19%)
		Cullin_Nedd8	606..661	CDD:287520	28/54 (52%)
cul4b	XP_017951653.1	Cullin	169..766	CDD:366357	119/634 (19%)
cul4b	XP_017951653.1	Cullin_Nedd8	794..859	CDD:214883	31/66 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920