Protein Alignment Cul6 and cul5b

DIOPT Version :9

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: XP_009293667.1
• Gene: cul5b / 100006147
• ZFINID: ZDB-GENE-091113-45
• Length: 807
• Species: Danio rerio
• Alignment Length: 853
• Identity: 181/853 - (21%)
• Similarity: 324/853 - (37%)
• Gaps: 258/853 - (30%)

  Fly    11 FDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDC 75
            :|.|.|:   :|:::.|     .|...|:...|:..::..|.    |::   |....::..|.:.
Zfish    19 WDLMRPI---VLKLLRQ-----ESVTKQQWFDLFSDVHAVCL----WDD---KGPAKIHQALKED 68

  Fly    76 LMKRLKNIAWVMENQL-------------DDNKPIRLIAKYLEHWVPYQRSCE-------KLNLA 120
            ::..:|. |..|||.:             ||.   .|:..|:..|..:...|:       ||.:.
Zfish    69 ILDFIKQ-AQAMENIIVFLSLCVRVLSHQDDT---ALLKAYIVEWRKFFTQCDILPKPFSKLEIT 129

  Fly   121 CYHFNRNWVERERLKGDKETYPIYRLAMISWKELVFEPSVTIL--AAIRLI-LSQMPREYNKSLE 182
            ... |:.    ...|.:.|...:.:|.:.:|.|.:|....:.|  :|::|: ..::...::..|
Zfish   130 LLG-NQG----SNKKSNVEDSIVRKLMLDTWNESIFCNIKSRLQDSAMKLVHAERLGEAFDSQL- 188

  Fly   183 YQVYQVLQSIVELYAN--DKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYK----- 240
              |..|.:|.|.|.:|  ||.|  ......:|.:.:....|||:......|:..|.|..|
Zfish   189 --VIGVRESYVNLCSNTDDKLQ--IYRENFEKSYLDSTERFYKTQAPSYLQQNGVQNYMKYADGK 249

  Fly   241 ---DFKHFLRY-------------------------------ACLAM-----PEIE----NGTQF 262
               :.|..|||                               .|..|     .|.|    :||:.
Zfish   250 LREEEKRALRYLETRRECNSVQALMECCVNALVTSFKETILTECPGMIKRNETESEYGRSSGTKG 314

  Fly   263 KAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEE---------- 317
            .|..:.:|...|.:...||.:           |:.:.|.||...|.:.|.|...|
Zfish   315 SASSELHLMFSLMDKVPSGIE-----------PMLKDLEDHIMSAGLADMVASAETITTDSEKYV 368

  Fly   318 ------INRKGQII------DPTRLLVTYANELMTKRQESEEAIIDE---------LKR------ 355
                  .||..:::      ||         ..:|.|.::.:|::::         ||:
Zfish   369 EQLLTLFNRFSKLVKEAFQDDP---------RFLTSRDKAYKAVVNDATIFKLELPLKQKGVSLK 424

  Fly   356 ---IVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLL-------NKKM------A 404
               ..||.|.|::   :.||   .||...:::..||:.:|:.:..:|       ||.:      |
Zfish   425 TQPESKCPELLAN---YCDM---LLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKA 483

  Fly   405 NFVTRCI------------YVQ-LRDV----DKLRTLKKEFQDHLNSKGIKLGFDFRPKCFK--- 449
            :...|.|            .|: ||:|    |.:..|.:.|||...|:.:...|....|..|
Zfish   484 HLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQSFKEMHKHNKLAL 548

  Fly   450 ----------NDG----SFENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEITC 500
                      |.|    |.|...::||.||:....|...||  :|..|...:..::.:|:|.||.
Zfish   549 PADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEDFY--KKNHSGRKLHWHHLMSNGIITF 611

  Fly   501 HLNQSVYILEVSTLQMAVLMLFNR--HERFTEQELVTALGVELETLQEALKQIKFLVYIEVNKVN 563
            ......|.|||:|.|:|||..:|:  .||.:.:.|..|..:....|:..|..:.....::...::
Zfish   612 KNEVGQYDLEVTTFQLAVLFAWNQRPRERISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLS 676

  Fly   564 Y---------------IEINMDFTNRKRRLFCNEPLPR---------------KMRKIEEKSEIE 598
            |               ..||.:|:     |..|..:.:               :||:.|.:..::
Zfish   677 YEPVVGSPKDFAEGTVFSINQEFS-----LIKNSKVQKRGKINLIGRLQLTTERMREEENEGIVQ 736

  Fly   599 LKIRRDKQVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERDNY 663
            |:|.|.::   ||::|||.:|::..::|.:.:.|.||:...||...||:::::|:|.:|::||..
Zfish   737 LRILRTQE---AIIQIMKMRKRISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIKRDET 798

  Fly   664 -YNIYRYL 670
             .|.:.|:
Zfish   799 DINTFIYM 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	176/837 (21%)
		CULLIN	362..500	CDD:214545	43/184 (23%)
		Cullin_Nedd8	606..661	CDD:287520	17/54 (31%)
cul5b	XP_009293667.1	Cullin	20..698	CDD:279260	151/734 (21%)
		CULLIN	470..613	CDD:214545	35/144 (24%)
		Cullin_Nedd8	740..799	CDD:287520	20/61 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820