Protein Alignment Cul6 and cul5b

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: XP_073791420.1
• Gene: cul5b / 100006147
• ZFINID: ZDB-GENE-091113-45
• Length: 837
• Species: Danio rerio
• Alignment Length: 872
• Identity: 183/872 - (20%)
• Similarity: 327/872 - (37%)
• Gaps: 266/872 - (30%)

  Fly    11 FDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDC 75
            :|.|.|:   :|:::.|     .|...|:...|:..::..|.    |::   |....::..|.:.
Zfish    19 WDLMRPI---VLKLLRQ-----ESVTKQQWFDLFSDVHAVCL----WDD---KGPAKIHQALKED 68

  Fly    76 LMKRLKNI-AWVMENQLDDNKPIRLIAKYLEHWVPYQRSCE-------KLNLACYHFNRNWVERE 132
            ::..:|.. |.|:.:| ||.   .|:..|:..|..:...|:       ||.:.... |:.    .
Zfish    69 ILDFIKQAQARVLSHQ-DDT---ALLKAYIVEWRKFFTQCDILPKPFSKLEITLLG-NQG----S 124

  Fly   133 RLKGDKETYPIYRLAMISWKELVFEPSVTIL--AAIRLI-LSQMPREYNKSLEYQVYQVLQSIVE 194
            ..|.:.|...:.:|.:.:|.|.:|....:.|  :|::|: ..::...::..|   |..|.:|.|.
Zfish   125 NKKSNVEDSIVRKLMLDTWNESIFCNIKSRLQDSAMKLVHAERLGEAFDSQL---VIGVRESYVN 186

  Fly   195 LYAN--DKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLR-YAC------ 250
            |.:|  ||.|  ......:|.:.:....|||:......|:..|.|..|.|....| |..
Zfish   187 LCSNTDDKLQ--IYRENFEKSYLDSTERFYKTQAPSYLQQNGVQNYMKYFSFLHRSYTSQLHPRQ 249

  Fly   251 ----------LAMPEIENG---TQFKAILK---------RYLAAR--------LQETRLSG--KD 283
                      ||....::|   :..||..|         |||..|        |.|..::.  ..
Zfish   250 RFLPDQFVTDLANQHYQDGKVLSHSKADGKLREEEKRALRYLETRRECNSVQALMECCVNALVTS 314

  Fly   284 YIQAFLGLCRG----------------------------------------PLQRALRDHTKLAE 308
            :.:..|..|.|                                        |:.:.|.||...|.
Zfish   315 FKETILTECPGMIKRNETESEYGRSSGTKGSASSELHLMFSLMDKVPSGIEPMLKDLEDHIMSAG 379

  Fly   309 VVDAVCKEE----------------INRKGQII------DPTRLLVTYANELMTKRQESEEAIID 351
            :.|.|...|                .||..:::      ||         ..:|.|.::.:|:::
Zfish   380 LADMVASAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDP---------RFLTSRDKAYKAVVN 435

  Fly   352 E---------LKR---------IVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSL 398
            :         ||:         ..||.|.|::   :.||   .||...:::..||:.:|:.:..:
Zfish   436 DATIFKLELPLKQKGVSLKTQPESKCPELLAN---YCDM---LLRKTPLSKKLTSEEIEAKLKEV 494

  Fly   399 L-------NKKM------ANFVTRCI------------YVQ-LRDV----DKLRTLKKEFQDHLN 433
            |       ||.:      |:...|.|            .|: ||:|    |.:..|.:.|||...
Zfish   495 LLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKV 559

  Fly   434 SKGIKLGFDFRPKCFK-------------NDG----SFENFNLTLPDELQQAWKEFRIFYEARKL 481
            |:.:...|....|..|             |.|    |.|...::||.||:....|...||  :|.
Zfish   560 SEDLNQSFKEMHKHNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEDFY--KKN 622

  Fly   482 QSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNR--HERFTEQELVTALGVELETL 544
            .|...:..::.:|:|.||.......|.|||:|.|:|||..:|:  .||.:.:.|..|..:....|
Zfish   623 HSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPRERISFENLKLATELPDAEL 687

  Fly   545 QEALKQIKFLVYIEVNKVNY---------------IEINMDFTNRKRRLFCNEPLPR-------- 586
            :..|..:.....::...::|               ..||.:|:     |..|..:.:
Zfish   688 RRTLWSLVAFPKLKRQVLSYEPVVGSPKDFAEGTVFSINQEFS-----LIKNSKVQKRGKINLIG 747

  Fly   587 -------KMRKIEEKSEIELKIRRDKQVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSF 644
                   :||:.|.:..::|:|.|.::   ||::|||.:|::..::|.:.:.|.||:...||...
Zfish   748 RLQLTTERMREEENEGIVQLRILRTQE---AIIQIMKMRKRISNAQLQTELVEILKNMFLPQKKM 809

  Fly   645 IKKRLDYLVEREYLERDNY-YNIYRYL 670
            ||:::::|:|.:|::||.. .|.:.|:
Zfish   810 IKEQIEWLIEHKYIKRDETDINTFIYM 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	178/856 (21%)
cul5b	XP_073791420.1	None