Protein Alignment CG42588 and TFC6

DIOPT Version :10

• Sequence 1: NP_648604.2
• Gene: CG42588 / 39457
• FlyBaseID: FBgn0260965
• Length: 2730
• Species: Drosophila melanogaster
• Sequence 2: NP_010649.1
• Gene: TFC6 / 851964
• SGDID: S000002770
• Length: 672
• Species: Saccharomyces cerevisiae
• Alignment Length: 1050
• Identity: 180/1050 - (17%)
• Similarity: 289/1050 - (27%)
• Gaps: 451/1050 - (42%)

  Fly  1739 IVPPVSQPKPEKLHEQNRDESVRA--PKEQLDPTTSKNSRGKRQSRSIA---------------- 1785
            ::|...:.:|.|        ||.|  |.:.|....|:||..||..|:.:
Yeast     3 VIPAKKRGRPRK--------SVVAEVPYDSLASPVSENSGSKRPRRNASKKAVANFAQLVHAGRD 59

  Fly  1786 -ATNTPTTMLTTASEDPEAV--------EGDSVEVPIKRKASTRRGSVPRDTPISSVNASDESAV 1841
             ..||........::|.:.|        |.|:||:..:.:..:.:..|      :.:|:|...|
Yeast    60 DVINTTQVNNVDDTDDDDFVLNDEGDGEESDNVEIEFENELESTKNEV------ADLNSSGSGA- 117

  Fly  1842 LESVPKKGRRSNISSVPADTTIPKSSKSDSLNAIEIIPPICEEPKVVPSKRGRKRAAPSDIETGL 1906
              ||...|||:.:..:.......|:.||.|             |.....::||......|:.:..
Yeast   118 --SVRPSGRRNTVQKLRLKKNSTKNMKSSS-------------PGSSLGQKGRPIRLLKDLSSAR 167

  Fly  1907 AKKLKTEESSETERVVDFNLR--LLLIRKRDQLDTDEVLTNDGKGQGPLQCGLCLVRSDKNNWQR 1969
            .|         .||:...|..  |||.:.::..:|.
Yeast   168 DK---------IERIYGLNKEKLLLLAKVKEGFETS----------------------------- 194

  Fly  1970 HIGEHYGVGWLVGETP-KNITRSGIMTMMKNYLQKNGGKLTCRLCNHQLGSYLGMMLHLEGCGNK 2033
                       |.:.| |||             |.:.....|
Yeast   195 -----------VFDFPFKNI-------------QPDSPYFVC----------------------- 212

  Fly  2034 QRFQCEFCQRSYTKLSLPVHIRTCPKRIAPQVTEDPEDADGDCKETVFSNAGRAKRKSTIKAETK 2098
                          |..|     |.|..|      .....||...||:....:.:.::.||..||
Yeast   213 --------------LDPP-----CKKESA------YNKVIGDKNRTVYHEINKTEFENMIKLRTK 252

  Fly  2099 LKK--IGEALTTQKSGEGASAKNDFDGDSSDYDLTKDKESSEEYDSEGVDSNEDSISSEGEGSLG 2161
            ..|  |||.                                                 :.|.|.|
Yeast   253 RLKLLIGEV-------------------------------------------------DAEVSTG 268

  Fly  2162 DNFSTSKQSKANRRGDIDRKRICNRPVNVGECQQKPLLSRYHHLEARATHKWNEFVQRNYEAGAL 2226
            |.......:...|||.|                                          |..|.|
Yeast   269 DKIEFPVLANGKRRGFI------------------------------------------YNVGGL 291

  Fly  2227 FTQLVPSYSKIPEKNTDGMLPPKNTPSMRYSYGKVKNEDDWKQLAPFEGFNKEGEYVGYLGSSIK 2291
            .|.:  ::..| |:|||                                          :|..|:
Yeast   292 VTDI--AWLNI-EENTD------------------------------------------IGKDIQ 311

  Fly  2292 KLEWVPLPPKAASQYLLCSVRSKMKTFARHK--------KLKDEDGLLMLLKCTAKNAGKSWTLR 2348
            .|      ..|.|||:...:...::.|.:.|        |:.......:.::....:.|:.|.|:
Yeast   312 YL------AVAVSQYMDEPLNEHLEMFDKEKHSSCIQIFKMNTSTLHCVKVQTIVHSFGEVWDLK 370

  Fly  2349 PELHYCVHVPNGPIHSFSFLPSGGYDKSSNRLGVLAVANSLSSVHIY------ALPLELANDEID 2407
              .|...|.|: .:...||:...|      .:..|.:.::.:.||::      :|.|.||
Yeast   371 --WHEGCHAPH-LVGCLSFVSQEG------TINFLEIIDNATDVHVFKMCEKPSLTLSLA----- 421

  Fly  2408 ENADEKVVIQLDSLITLTLDINNPVQDQCTKICWSLSAGHSFLATGYSSGHFALWDIGEKDNLNC 2472
                       ||||| |.|..:|.    |.:|            |:.:|..|.:|:.:.:
Yeast   422 -----------DSLIT-TFDFLSPT----TVVC------------GFKNGFVAEFDLTDPE---- 454

  Fly  2473 FIRNNQTHFVP-----VNFLYIGERNVQYMDLHYDNNGPRWLAVGTSIRQFKIYDIANWSNPYIL 2532
                     ||     |:..||...:..|.|  :::.....:||......|...|||.
Yeast   455 ---------VPSFYDQVHDSYILSVSTAYSD--FEDTVVSTVAVDGYFYIFNPKDIAT------- 501

  Fly  2533 TQDTISSLYMANLTWSPICEALVVSSSHFFRTIAVS----PSGIQFEHRTLDGTLTTTREMHTNC 2593
            |:.|:|....:||.....|..:.   |:.:...|.|    ||...|....|....||
Yeast   502 TKTTVSRFRGSNLVPVVYCPQIY---SYIYSDGASSLRAVPSRAAFAVHPLVSRETT-------- 555

  Fly  2594 QQNHMVFVTDNGDLVFLDVRNLNCGPALLKSTVNSRAVSTTELHHL--GSSAPSATD-------- 2648
                         :..:.|..|:  |.:|..:.:...:.|.....|  |....|||.
Yeast   556 -------------ITAIGVSRLH--PMVLAGSADGSLIITNAARRLLHGIKNSSATQKSLRLWKW 605

  Fly  2649 --PIDPDEFVRDYGLQINPLVPEPHKRKSTYLSAKRRPQNIHSLAMTRFNCVRCNWNSPTHTWVA 2711
              .|..|::..|...::.||         |.....:...:.|.:.:|   |.:.|..|......|
Yeast   606 DYSIKDDKYRIDSSYEVYPL---------TVNDVSKAKIDAHGINIT---CTKWNETSAGGKCYA 658

  Fly  2712 MGAEHGMLRI 2721
            .....|:|.:
Yeast   659 FSNSAGLLTL 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42588	NP_648604.2	PHA03247	<11..541	CDD:223021
		WD40 repeat	2363..2403	CDD:293791	9/45 (20%)
		WD40 repeat	2437..2477	CDD:293791	6/39 (15%)
		WD40 repeat	2484..2533	CDD:293791	11/48 (23%)
		WD40 repeat	2541..2588	CDD:293791	12/50 (24%)
TFC6	NP_010649.1	None