Protein Alignment Sap130 and SAP130

DIOPT Version :10

• Sequence 1: NP_729834.1
• Gene: Sap130 / 39455
• FlyBaseID: FBgn0262714
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_001139400.1
• Gene: SAP130 / 79595
• HGNCID: 29813
• Length: 1083
• Species: Homo sapiens
• Alignment Length: 1395
• Identity: 301/1395 - (21%)
• Similarity: 502/1395 - (35%)
• Gaps: 422/1395 - (30%)

  Fly     4 PSEGGAGGGPVGGGSTATAPSAPLKTIKIRTQQLHTHAVPSLSLLPSIYPSSSSSSLAATGSLSA 68
            |..|....|..|||...        .:::.:||......||..|      |.:.|.:|.:|
Human     7 PQAGEIEAGGAGGGRRL--------QVEMSSQQFPRLGAPSTGL------SQAPSQIANSG---- 53

  Fly    69 SASLVSHSHPPLQLRGVINKYSLPSHLPSSAA---------------HPAVAAKITHVKSDGGGG 118
            ||.|::.:.......|..::.|...|:.||::               :|.|....||
Human    54 SAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTH-------- 110

  Fly   119 ISIAGTPILSGGTIKVASANQVQQTSLGGTPIALNAGQATTAASIRAIGAGGQSTQVRVVMPMIK 183
                         ..||||          ||:|:.|..|....::....:.|          ::|
Human   111 -------------HAVASA----------TPVAVTAPPAHLTPAVPLSFSEG----------LMK 142

  Fly   184 QLENVTATGRTQITAIPAA---PARSGANASITVTRPVTQATYLPRASVTATQMGGVGVGVGQRL 245
            .....|...|....|.|:.   |.:.....::|:...:.||:.:|.|:::..|  |....:...:
Human   143 PPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQ--GHPSNLHHIM 205

  Fly   246 VTPLRATSSATVTPTAPTVLSSTGGFVRGATAS--VSRSGVALTSQPSSAVISSSNSGAWMQSQG 308
            .|.::.:...:..|..|..:.:: ...|||.|:  :|.|.|....:|:|.:.:::.      :|.
Human   206 TTNVQMSIIRSNAPGPPLHIGAS-HLPRGAAAAAVMSSSKVTTVLRPTSQLPNAAT------AQP 263

  Fly   309 QVQLIRTIHQPRQR--------------IITTSAGVSNASVVTTTPVQA-PTALSVSAGQPLATQ 358
            .||.|  ||||.|.              :.|.||..:.:.|:|||...| .:|||    :|..:.
Human   264 AVQHI--IHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALS----RPTLSI 322

  Fly   359 QATGPGGGPQAYVATVLPQRQHQATLVYSSNVSAPN--ASQNPGQQFNPRFAVATPTGGVTTTTP 421
            |..     |.|.::...|.:....|    :.::.|:  |...|.||.:        |....|...
Human   323 QHP-----PSAAISIQRPAQSRDVT----TRITLPSHPALGTPKQQLH--------TMAQKTIFS 370

  Fly   422 GGTTVTPRQVRPIPLGKSFPTAKLNTTSISIRAPSIPQLNTSVTASPTAVSVSGGATVAPGRGPG 486
            .||.|....|.||....:.|:|   ||:.|:          |.|.:||:..|:   ...|.....
Human   371 TGTPVAAATVAPILATNTIPSA---TTAGSV----------SHTQAPTSTIVT---MTVPSHSSH 419

  Fly   487 AGGTALTATNLPTTRIIQLQQPATGTTQQIIG------------SGARLAGNVMLQPFLMSTTAA 539
            |  ||:|.:|:|..:::  .|..|.|:.:|..            ||.|.:.|    |..|.|
Human   420 A--TAVTTSNIPVAKVV--PQQITHTSPRIQPDYPAERSSLIPISGHRASPN----PVAMET--- 473

  Fly   540 AKMGIRPPVTMTAK-----VQPS---LTITQLNPIGKLSAGGGSGGQTMGPQGVASIQAVPVPNV 596
             :...||.|.:..:     ..||   |......||               ...|::|:..|   |
Human   474 -RSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPI---------------TSSVSTIRQYP---V 519

  Fly   597 SASVVNSSSVTGATSAAGGATV---------------------LPLTISGRGAGVGPGGNILTGT 640
            ||...| |::|..|.....:||                     .|..||.:|....|.|   |..
Human   520 SAQAPN-SAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIG---TPG 580

  Fly   641 LTP-------IKNASGITLGKMMMAP-ASSAPGADGSSTS-----GATVTGFQRTWNPVVASQSQ 692
            :.|       |.:|:.|....:..|| .:..|..:|.:::     |||:..     ||:
Human   581 IQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVA-----NPI------ 634

  Fly   693 LMKIDEKGSAATIYYESMPASASTGVLSLTTTTVTQSTQAQAQLVSSAGGSLSVSSLPFASHATA 757
                            |.|.||:.     ..|||.|:....|...:.|.||....|:.....||
Human   635 ----------------SNPFSAAP-----AATTVVQTHSQSASTNAPAQGSSPRPSILRKKPAT- 677

  Fly   758 GAGSGGGGSQATFTVLPSGAGGTATRTIGHQQLIIPAGPNSAPPQHMVIPLHTSVKVTTGAGNPQ 822
                                .|.|.|    :.||.|..|:.|.|:     :.:|::.|:|:..|
Human   678 --------------------DGMAVR----KTLIPPQPPDVASPR-----VESSMRSTSGSPRP- 712

  Fly   823 QATASGALVSSFMRKRDAEGSPIRAAKNLGPTLLSMASNNSGQNMPPAPGTTFNIQPVSVTVPQS 887
                :||...|.:.                   :|||:                  ||:|
Human   713 ----AGAKPKSEIH-------------------VSMAT------------------PVTV----- 731

  Fly   888 VGSGLTVEALAKKERERVTHGVASSAASVPATVGPVNSTRNSRADSPASSDGSTTVSANSSPG-- 950
                 ::|.::.:..::.|..|..:|...|.|: |......|....||       |:.::.||
Human   732 -----SMETVSNQNNDQPTIAVPPTAQQPPPTI-PTMIAAASPPSQPA-------VALSTIPGAV 783

  Fly   951 -VDQQLQDRIGDQPATGGAGGRDNSTHFNPINEMYSSHQSIQQNLGHSSLGARSGSSAFVDVQAP 1014
             :...:.......|.:...||..:|....|:.|:     .:::.:..            :|:..|
Human   784 PITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEI-----KVKEEVEP------------MDIMRP 831

  Fly  1015 TPQQQQPQQVPHLVGSTQMQQGTRMNGTGNSSSSSYD----CSSRKKPRRSTNDSQHSTQSQASL 1075
            .      ..||.|..:|.......:  ..|.|..:.|    .|.|||||:    .||...::...
Human   832 V------SAVPPLATNTVSPSLALL--ANNLSMPTSDLPPGASPRKKPRK----QQHVISTEEGD 884

  Fly  1076 SLPPPSSEPTPPAGASYMQKHNNGGLLVTAATPGVAPNSAPGDANHRNSTPAVAGNKENANPVDF 1140
            .:...|::.......|.:.|                       |..|.|.|....::|.   |.:
Human   885 MMETNSTDDEKSTAKSLLVK-----------------------AEKRKSPPKEYIDEEG---VRY 923

  Fly  1141 VIRRPR-NCALLNTYKPTHKLANNHFHRYTDVKPREERRATVIDLANQPNVQGKINGWKIYHLRS 1204
            |..||| ...||..|:...|.|.:||.||:||:.:||::|.:.::|||..|..:..|||::...:
Human   924 VPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAA 988

  Fly  1205 QMEDLNESEVFSLGRLETMLQDL--EKDKEKHSEIERVTELLKGNIQRSKIITDGINEAQNQLMK 1267
            |:..|...|.....||..:.:.:  :|......::.|:.||::||:||.|::.|.|:||::.::|
Human   989 QLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLK 1053

  Fly  1268 IFEHKPHVSNIITRCASKR---NFKKREKI 1294
            :.:||..|..::.:..:.:   ..|::||:
Human  1054 VLDHKDRVLKLLNKNGTVKKVSKLKRKEKV 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sap130	NP_729834.1	SAP130_C	<1110..1275	CDD:464973	52/167 (31%)
SAP130	NP_001139400.1	PHA03247	<45..365	CDD:223021	82/396 (21%)
		Atrophin-1	466..>847	CDD:460830	106/555 (19%)
		SAP130_C	661..1066	CDD:464973	120/549 (22%)