Protein Alignment Sap130 and sap130b

DIOPT Version :10

• Sequence 1: NP_729834.1
• Gene: Sap130 / 39455
• FlyBaseID: FBgn0262714
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_001243552.1
• Gene: sap130b / 335897
• ZFINID: ZDB-GENE-070912-570
• Length: 1043
• Species: Danio rerio
• Alignment Length: 1383
• Identity: 304/1383 - (21%)
• Similarity: 488/1383 - (35%)
• Gaps: 448/1383 - (32%)

  Fly     4 PSEGGAGGGPVGGGSTATAPSAPLKTIKIRTQQLHTHAVPSLSLLPSIYPSSSSSSLAATGSLSA 68
            ||  |.|.|...|.:||..|.:...|    ..:...||           |....||.|.......
Zfish    12 PS--GLGQGQTAGNNTAGFPGSQKST----GHEDSNHA-----------PRELMSSGATVFRDDK 59

  Fly    69 SASLVSHSHPPLQLRGVINKYS------LPSHLPSSAAHPAVAAKITHVKSDGGGGISIAGTPIL 127
            ..::|...:|..|::...:..:      ||.|||....  :|:|..:|:..    |:|:|.|.
Zfish    60 QETVVVRPYPQPQMQPPSHGAAPTLPPPLPQHLPIQPV--SVSAAPSHLPQ----GLSLAFTE-- 116

  Fly   128 SGGTIKVASANQVQQTSLGGTPIALNAGQATTAASIRAIGAGGQSTQVRVVMPMIKQLENVTATG 192
              |::|                .||.|..::                 ||:.|       .....
Zfish   117 --GSLK----------------SALKAPMSS-----------------RVIAP-------APVPT 139

  Fly   193 RTQITAIPAAPARSGANASITVTRPVTQATYLPRASVTATQ--MGGVGVGVGQRLVTPLRATSS- 254
            .:.:|..|..|..      :|.|...|||:.:|.|:::..|  .|.:     ..|:|.::...|
Zfish   140 PSHLTLPPKVPGH------LTATMESTQASGIPVATISGQQGHSGNL-----HHLMTSVQIIRSG 193

  Fly   255 -------ATVTP------------TAPTVLSSTGGFVRGATASVSRSGVALTSQPSSAVISSSNS 300
                   ::..|            .|..|:||:    :|||      |:...:.||||.
Zfish   194 APVQQIGSSAAPQHCFPSHLPRGAAAAAVMSSS----KGAT------GLRPAAGPSSAT------ 242

  Fly   301 GAWMQSQGQVQLIRTIHQPRQR--IITTSAGVSNASV--VTTTPVQAPTALSVSA--GQPLATQQ 359
                   ||..:...||||.|.  |:|||..|....|  ||.|..|:|...:|:|  |..:..:.
Zfish   243 -------GQPTVQHIIHQPIQSRPIVTTSTAVLPTVVAPVTATRPQSPVITTVAAHSGDMVHGRS 300

  Fly   360 ATG--PGGGPQAYVATVLPQRQH----QATLVYSSNVSAPNASQNPGQQFNPRFAVATPTGGVTT 418
            |..  |   |||.::...|....    :.||.....::|..|..:...| .|.|:..||.
Zfish   301 AVAIHP---PQATLSIQRPPPSRDTPTRITLPSHPAIAAQKALSHSVAQ-KPIFSTVTPV----- 356

  Fly   419 TTPGGTTVTPRQVRPIPLGKSFPTAKLNTTSISIRAPSIP--QLNTSVTASPTAVSVSGGATVAP 481
               ...||.|.||             .||........|.|  |::.|...:.|..|.|..|
Zfish   357 ---AAATVAPIQV-------------TNTAPSPTTTGSTPHTQISNSNIVTMTVASHSSHA---- 401

  Fly   482 GRGPGAGGTALTATNLPTTRIIQLQQPATGTTQQIIG-----------SGARLAGN--------- 526
                    ||:|.:.:|..:::  .||.|.|:.:|..           ||.|.:.|
Zfish   402 --------TAVTTSTIPVAKVV--PQPITHTSPRIQSEYTERGNLIPISGHRSSPNPITMENRTD 456

  Fly   527 ------VMLQPFLMSTTAAAKMGIRPPVTMTAKVQP-SLTITQLNPIGKLSAGGGSGGQTMGPQG 584
                  |..|.||.:..:|       |..:|....| :.:::.:.|....:....:...|....|
Zfish   457 NRQSVPVQFQYFLPTYQSA-------PYPLTHTYTPITSSVSSIRPYPVTAQAPSAAMPTQAGVG 514

  Fly   585 VA------SIQAVPVPNVSASVVNSSSV-TGATSAAGGATVLPLTISGRGAGVGPGGNILTGTLT 642
            ||      |:|.:.|..::.  :|:.:: .||.:|.|   :.|..|        |..|:.|
Zfish   515 VASAVHLNSMQLMTVDRITQ--INTQNIQPGAMTAQG---IQPTPI--------PAQNLHT---- 562

  Fly   643 PIKNASGITLGKMMMAPASSAPGADGSSTSGATVTGFQRTWNPVVASQSQLMKIDEKGSAATIYY 707
                ::.||...:..:|.:.......|..|            .|:|..|.||    ..|.:..:.
Zfish   563 ----SAQITTPSIQPSPVNQQQPPTESKAS------------VVLADGSTLM----ANSISNAFS 607

  Fly   708 ESMPASASTGVLSLTTTTVTQSTQAQAQLVSSAGGSLSVSSLPFASHATAGAGSGGGGSQATFTV 772
            .|.|           |||:     ||..:.::..|:.|:.:.|..|.......:.|...:.  .:
Zfish   608 NSQP-----------TTTL-----AQTHIQNANTGTPSLVTSPRPSILRKKPANEGAAVRK--NL 654

  Fly   773 LPSGAGGTATRTI--------GHQQLIIPAGPNSAPPQHMVIPLHTSVKVTTGAGNPQQATASGA 829
            :|:..|.|....|        |..:   |||....|..||.:.             |..|.|..|
Zfish   655 IPAQLGDTTAPRIDGPIRSASGSPR---PAGVKPKPDIHMSLA-------------PSVAAAIEA 703

  Fly   830 LVSSFMRKRDAEGSPIRAAKNLGPTLLSMASNNSGQNMPPAPGTTFNIQPVSVTVPQSVGSGLTV 894
            :.|        :|:. :.|:::||....:||.       |.|....::.|.|:..|
Zfish   704 IPS--------QGTE-QQAQHVGPPSSQLASQ-------PLPSLLASVTPPSLPAP--------- 743

  Fly   895 EALAKKERERVTHGVASSAASVPATV-GPVNSTRNSRAD--SPASSDGSTTVSANSSPGVDQQLQ 956
                           |.||.....|| .|:.|..|..|.  .||:::.|.....::.|.::
Zfish   744 ---------------ALSALPAAMTVTQPIPSMTNVVAQPIQPAANNTSVCTINSNLPELN---- 789

  Fly   957 DRIGDQPATGGAGGRDNSTHFNPINEMYSSHQSIQQNLGHSSLGARSGSSAFVDVQAPTPQQQQP 1021
              |..:|..     .|:|   .|:                 :||..||:              |.
Zfish   790 --IKQEPEP-----MDSS---KPV-----------------ALGPNSGA--------------QM 813

  Fly  1022 QQVPHLVGSTQMQQGTRMNGTGNSSSSSYDCSSRKKPRRSTNDSQH--STQSQASLSLPPPSSEP 1084
            ..||    .|.:..|               .|.|||||:    .||  ||:....:.......|.
Zfish   814 LTVP----PTDLTLG---------------ASPRKKPRK----QQHIISTEESEMMETNSTDEEK 855

  Fly  1085 TPPAGASYMQKHNNGGLLVTAATPGVAPNSAPGDANHRNSTPAVAGNKENANPVDFVIRRPRNCA 1149
            .||...|..                         |..|.|.|....::|....|...:|.|  ..
Zfish   856 FPPKPLSQR-------------------------AEKRKSPPKEYIDEEGVRYVPARVRPP--IT 893

  Fly  1150 LLNTYKPTHKLANNHFHRYTDVKPREERRATVIDLANQPNVQGKINGWKIYHLRSQMEDLN--ES 1212
            ||..|:...|.|.:||.||:||:.:|:::.::.|:|||..|..:..||||:...:|:..|:  |.
Zfish   894 LLRHYRNPWKAAYHHFQRYSDVRIKEDKKGSMQDVANQKGVVCRAQGWKIHLCAAQLMQLSNLEH 958

  Fly  1213 EVFSLGRLETMLQDLEKDKEKHSEIE--RVTELLKGNIQRSKIITDGINEAQNQLMKIFEHKPHV 1275
            :|:|  ||.|:.:.....|:..::::  |:.||::||:||.|::.|.|.||::.::|:.:||..|
Zfish   959 DVYS--RLTTLQEGFVPKKKAGADVDLHRINELIQGNMQRCKLVMDQITEARDSMLKVLDHKERV 1021

  Fly  1276 SNIITRCASKRNFKKREK 1293
            ..::.:.:|.:...|.::
Zfish  1022 LKLLNKNSSTKKLNKLKR 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sap130	NP_729834.1	SAP130_C	<1110..1275	CDD:464973	53/168 (32%)
sap130b	NP_001243552.1	PHA03247	<8..428	CDD:223021	127/555 (23%)
		DUF5585	<318..>587	CDD:465521	67/332 (20%)
		SAP130_C	629..1026	CDD:464973	126/551 (23%)