Protein Alignment Sap130 and Sap130

DIOPT Version :10

• Sequence 1: NP_729834.1
• Gene: Sap130 / 39455
• FlyBaseID: FBgn0262714
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: XP_006526012.1
• Gene: Sap130 / 269003
• MGIID: 1919782
• Length: 1077
• Species: Mus musculus
• Alignment Length: 1391
• Identity: 295/1391 - (21%)
• Similarity: 482/1391 - (34%)
• Gaps: 446/1391 - (32%)

  Fly     1 MSAPSEGGAGGGPVG------------------GGSTATAPSAPLKTIKIRTQQLHTHAVPSLSL 47
            :|.|....|..|..|                  |......||:.|...:.:.:.:.....|.:.:
Mouse    36 LSQPPSQIASSGSAGLINQVATVNDEAGRDADVGTREHVGPSSSLPPREEKQEPVVVRPYPQVQM 100

  Fly    48 LPSIYPSSSSSSLAATG---------SLSASASLVSHSHPPLQLRGVINKYSLPSHLPSSAAHPA 103
            ||:.:..:|::.:|.|.         .||.|..|:.   ||       .|.::||. |.:.|.|
Mouse   101 LPAHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMK---PP-------PKPTMPSR-PIAPAPP- 153

  Fly   104 VAAKITHVKSDGGGGISIAGTPILSGGTIKVASANQVQQTSLGGTPIALNAGQATTAASIRAIGA 168
                            |....|....|.:.|...:.:.|.|  ..|:|..:||....:::..|
Mouse   154 ----------------STMSLPPKVPGQVTVTMESSIPQAS--AIPVATISGQQGHPSNLHHI-- 198

  Fly   169 GGQSTQVRVVMPMIKQLENVTA----TGRTQITAIPAAPARSGANASITVTRPVTQATYLPRASV 229
              .:|.|:  |.:|:  .|...    .|.:.:....||.|...::...||.||.:|   ||.|
Mouse   199 --MTTNVQ--MSIIR--SNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQ---LPNA-- 252

  Fly   230 TATQMGGVGVGVGQRLVTPLRATSSATVTPTAPTVLSSTGG--------FVRGATASVSRSGVAL 286
             ||....|...:.|.:.:....|:|:|:.|.....:|:|..        ....|.:::||..:::
Mouse   253 -ATAQPAVQHLIHQPIQSRPPVTTSSTIPPAVVATVSATRAQSPVITTTAAHAADSTLSRPTLSI 316

  Fly   287 TSQPSSAVISSSNSGAWMQSQGQVQLIRT---------IHQPRQRIITTSAGVSNASVVTT-TPV 341
            ...||:|:.        :|...|.:.:.|         :..|:|::.|    ::..::.:| |||
Mouse   317 QHPPSAAIS--------IQRPAQSRDVTTRITLPSHPALGTPKQQLHT----MAQKTIFSTGTPV 369

  Fly   342 QAPTALSVSAGQPLATQQATGPGGGPQAYVATV----LPQRQHQATLVYSSNVSAPNASQNPGQQ 402
            .|.|...:.|...|.:....|.....||..:|:    :|.....||.|.:||:  |.|...|.|
Mouse   370 AAATVAPILATNTLPSTTTAGSVSHTQAPTSTIVTMTMPSHSSHATAVTTSNI--PVAKVVPQQ- 431

  Fly   403 FNPRFAVATPTGGVTTTTPGGTTVTPRQVRP---------IPLGKSFPTAKLNTTSISIR---AP 455
                         :|.|:|        :::|         ||:  |...|..|..::..|   .|
Mouse   432 -------------ITHTSP--------RIQPDYPPERSSLIPI--SGHRASPNPVAMETRNDNRP 473

  Fly   456 SIP-QLNTSVTASPTAVSVSGGATVAPGRGPGAGGTALTATNLPTT---RIIQLQQPATGTTQQI 516
            |:| |....:...|            |...|.|..|....|:..:|   ..:..|.|.:..|.|
Mouse   474 SVPVQFQYFLPTYP------------PSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSTITAQ- 525

  Fly   517 IGSGARLAGNVMLQPFLMSTTAAAK----MGIRPPVTMTAKVQPSLTITQLNPIGKLSAGGGSGG 577
              :|..:|..|.|.|..:.|..|:.    .||:|....|..:||:
Mouse   526 --TGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPA-------------------- 568

  Fly   578 QTMGPQGVASIQAVPVPNVSASVVNSSSVTGATSAAGGATVLPLTISGRGAGVGPGGNILTGTLT 642
                |.|.:.||..|:           ...|..|||
Mouse   569 ----PIGTSGIQPAPI-----------GTPGIHSAA----------------------------- 589

  Fly   643 PIKNASGITLGKMMMAPASSAPGADGSSTS-----GATVTGFQRTWNPVVASQSQLMKIDEKGSA 702
            ||.     |.|....|.|:..|..:|.:::     |||:..     ||:
Mouse   590 PIN-----TQGLQPAAMANQQPQPEGKTSAVVLADGATIVA-----NPI---------------- 628

  Fly   703 ATIYYESMPASASTGVLSLTTTTVTQSTQAQAQLVSSAGGSLSVSSLPFASHATAGAGSGGGGSQ 767
                  |.|.||:.     ..|||.|:....|...:.|.||....|:.....||
Mouse   629 ------SNPFSAAP-----AATTVVQTHSQSASTNTPAQGSSPRPSILRKKPAT----------- 671

  Fly   768 ATFTVLPSGAGGTATRTIGHQQLIIPAGPNSAPPQHMVIPLHTSVKVTTGAGNPQQATASGALVS 832
                      .|.|.|    :.|:.|..|:.|.|:                            |.
Mouse   672 ----------DGMAVR----KTLLPPQPPDVATPR----------------------------VE 694

  Fly   833 SFMRKRDAEGSPIRAAKNLGPTLLSMASNNSGQNMPPAPGTTFNIQPVSVTVPQSVGSGLTVEAL 897
            |.|  |.|.|||                       .||.....:...||:..|.:|    ::|.:
Mouse   695 SSM--RSASGSP-----------------------RPAGAKPKSEVHVSIATPVTV----SLETI 730

  Fly   898 AKKERERVTHGVASSAASVPATVGPVNSTRNSRADSPASSDGSTTVSANSSPGVDQQLQDRIGDQ 962
            :.:..|:.|..|..:|...|.|:..:.:     |.||.|   ...::.::.||.          .
Mouse   731 SNQNAEQPTVAVPPTAQQPPPTIPSMIA-----AASPPS---QPAIALSTIPGA----------V 777

  Fly   963 PATGGAGGRDNSTHFNPINEMYSSHQSIQQNLGHSSLGARSGSSAFVDVQAPTP-----QQQQPQ 1022
            |.|            .||..:.::          .:|.|..|.:....:..|.|     ::.:|.
Mouse   778 PVT------------PPITTIAAT----------PTLSAPVGGTPSTVLGPPVPEIKVKEEAEPV 820

  Fly  1023 QVPHLVGSTQMQQGTRMNGTGNSSSSSYDCSSRKKPRRSTNDSQHSTQSQAS-LSLPPPSSEP-T 1085
            .:...|.:.                          |..:||....|....|| ||:||....| .
Mouse   821 DITRPVSTV--------------------------PPLATNTVSPSLALLASNLSMPPSDLPPGA 859

  Fly  1086 PPAGASYMQKH----NNGGLLVTAATPG--VAPNSAPGDANHRNSTPAVAGNKENANPVDFVIRR 1144
            .|......|:|    ..|.::.|.:|..  .|..|....|..|.|.|....::|.   |.:|..|
Mouse   860 SPRKKPRKQQHVISTEEGDMMETNSTDDEKSAAKSLLVKAEKRKSPPKEYIDEEG---VRYVPVR 921

  Fly  1145 PR-NCALLNTYKPTHKLANNHFHRYTDVKPREERRATVIDLANQPNVQGKINGWKIYHLRSQMED 1208
            || ...||..|:...|.|.:||.||:||:.:||::|.:.::|||..|..:..|||::...:|:..
Mouse   922 PRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQ 986

  Fly  1209 LNESEVFSLGRLETMLQDL--EKDKEKHSEIERVTELLKGNIQRSKIITDGINEAQNQLMKIFEH 1271
            |...|.....||..:.:.:  :|......::.|:.||::||:||.|::.|.|:||::.::|:.:|
Mouse   987 LTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDH 1051

  Fly  1272 KPHVSNIITRCASKR---NFKKREKI 1294
            |..|..::.:..:.:   ..|::||:
Mouse  1052 KDRVLKLLNKNGTVKKVSKLKRKEKV 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sap130	NP_729834.1	SAP130_C	<1110..1275	CDD:464973	54/167 (32%)
Sap130	XP_006526012.1	PHA03247	<8..359	CDD:223021	76/370 (21%)
		PHA03247	<437..906	CDD:223021	92/493 (19%)
		SAP130_C	655..1060	CDD:464973	73/414 (18%)