Protein Alignment Sap130 and sap130

DIOPT Version :10

• Sequence 1: NP_729834.1
• Gene: Sap130 / 39455
• FlyBaseID: FBgn0262714
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: XP_012825454.1
• Gene: sap130 / 100127690
• XenbaseID: XB-GENE-6083596
• Length: 1054
• Species: Xenopus tropicalis
• Alignment Length: 1378
• Identity: 302/1378 - (21%)
• Similarity: 473/1378 - (34%)
• Gaps: 433/1378 - (31%)

  Fly     1 MSAP--SEGGA--GGGPVGGG-------------STATAPSAPLKTIKIRTQQLHTHAVPSLSLL 48
            ||.|  |..||  |..|.|.|             |.......|.:..|  .:.:.....|.:.:|
 Frog    22 MSIPQVSNSGATMGQNPQGQGDEIIRDMDVQSRDSIGAGTVLPSRDDK--QEPVVVRPYPQVQML 84

  Fly    49 PSIYPSSSSSSLAATGSLSASASLVSHSHPPLQLRGVINKYSLPSHLPSSAAHPAVAAKITHVKS 113
            .|.:|...:.||:.|...:...|.|     ||.....|.|.:..|.:||....||..:
 Frog    85 ASHHPLQPAPSLSMTAQPAHLTSAV-----PLSFSENILKQTSKSTMPSRPIAPAPPS------- 137

  Fly   114 DGGGGISIAGTPILSGGTIKVASANQVQQTSLGGTPIALNAGQATTAASIRAIGAGGQSTQVRVV 178
                  :::..|.:| |.:.|...:.:.|||  ..|:|..:||.....|:..|.|.     ..|.
 Frog   138 ------ALSAVPKVS-GQVTVTMESGLPQTS--AIPVATISGQQGHPNSLHHIVAA-----TNVQ 188

  Fly   179 MPMIKQLENVTATGRTQITAIPAAPARSGANASITVTRPVTQATYLPRASVTATQMGGVGVGVGQ 243
            |.:|:             ::.|..|...|             |::|||.:..|..|.      ..
 Frog   189 MSIIR-------------SSAPGPPLHIG-------------ASHLPRGAAAAAVMS------SS 221

  Fly   244 RLVTPLRATSSATVTPTAPTVLSSTGGFVRGATASVSRSGVALTSQPSSAVISSSNSGAWMQSQG 308
            ::.|.||..|:.  .|:|....|:|...:.....  ||..|..|:..:.||::
 Frog   222 KVTTMLRPASAQ--IPSAVAAQSATQHIIHPPIQ--SRPPVTTTTSVTPAVVA------------ 270

  Fly   309 QVQLIRTIHQPRQRIITTSAGVSNASVVTTTPVQA------PTALSVSAGQPLATQQATGPGGGP 367
                            |.||..:.:.|:||||..|      ||         |:.||...|
 Frog   271 ----------------TVSATRAQSPVITTTPAHAAEPVLRPT---------LSIQQHPPP---- 306

  Fly   368 QAYVATVLPQRQHQATLVYSSNVSAPNASQNP--GQQFNPRFAVATPTGGVTTTTPGGTTVTPRQ 430
                |.:..||..||....::.::.|.   :|  |.|.....|:|..|...|     |..|....
 Frog   307 ----AAISIQRSAQARDAATTRITLPT---HPALGAQKPQLHAMAQKTLFGT-----GNPVAAAT 359

  Fly   431 VRPIPLGKSFPTAKLNTTSISIRAPSIPQLNTSVTASPTAVSVSGGATVA-PGRGPGAGGTALTA 494
            |.||                 :...::|.:.||.:|..|.||.|...|:. |.....|  ||:||
 Frog   360 VAPI-----------------LATNTLPSVTTSGSAPHTQVSTSAIVTMTMPTHSSHA--TAVTA 405

  Fly   495 TNLPTTRIIQLQQPATGTTQQIIGSGARLAGNVMLQPFLMSTTAAAKMGIRP---PVTMTAKVQP 556
            :|:|..:::  .|..|.|:.:|........||::..|           |.|.   |:||.|:.:
 Frog   406 SNIPVAKVV--PQQITHTSPRIQSEYGTERGNLIPIP-----------GHRASPNPMTMEARSE- 456

  Fly   557 SLTITQLNPIGKLSAGGGSGGQTMGPQGVASIQAVPV------PNVSASVVNSSSVTGATSAAGG 615
                                          :.|.|||      |....|
 Frog   457 ------------------------------NRQPVPVQLQYFLPTYPPS---------------- 475

  Fly   616 ATVLPLTISGRGAGVGPGGNILTGTLTPIKNASGITLGKMMMAPASSAPGADGSSTSGATVTGFQ 680
              ..||.               ..|.|||                         ::|.:|:..:.
 Frog   476 --AYPLA---------------AHTYTPI-------------------------TSSVSTIRQYP 498

  Fly   681 RTWNPVVASQSQLMKIDEKGSAATIYYESMPASASTGVLSLTTTTVTQSTQAQAQLVSSAGGSLS 745
                  |::|:....|..:..|:|::...|.      ::::.|:........|...||:.|
 Frog   499 ------VSAQAPNSAITAQSVASTVHLNPMQ------LINMDTSHTRHIQGIQPAPVSAQG---- 547

  Fly   746 VSSLPFASHATAGAGSGGGGSQATFTVLPSGAGGTATRTIGHQQLIIPAGPNSAPPQHMVIPLHT 810
            :...||::.          |.|||    |....|....:|..|                  .:|.
 Frog   548 IQPSPFSAQ----------GIQAT----PINTQGIQQTSINTQ------------------AIHP 580

  Fly   811 SVKVTTGAGNPQQATASGALVSSFMRKRDAEGSPIRAAKNLGPTLLSMASNNSGQNMPPAPGTTF 875
            :..:|    |....|:|   |||.....:.:.|.:.|.   |.|:::...|           :||
 Frog   581 ATSIT----NQGVQTSS---VSSQQAPNEPKASVVLAE---GATIVANPIN-----------STF 624

  Fly   876 NIQPVSVTVPQS------------VGSGLTVEALAKKERERVTHGVASSAASVPATVGPVNSTRN 928
            :..|...||.||            .||......|.||.   .|.|::...:.:|...|...|.|.
 Frog   625 SATPAGTTVMQSHSQSPGISSSPAQGSSPRPSILRKKP---ATDGLSVRKSLIPPHPGDAVSPRQ 686

  Fly   929 SRADSPASSDGSTTVSANSSPGVDQQLQDRIGDQPATGGAGGRDNSTHFNPINEMYSSHQSIQQN 993
               ||...|..::...|.:.|..|..:....|   .||..|..|..   |....:.|||
 Frog   687 ---DSSLRSTSASPRPAGAKPKADLHVPVAPG---VTGDPGAADQP---NAAASLPSSH------ 736

  Fly   994 LGHSSLGARSGSSAFVDVQAPTPQQQQPQQVPHLVGSTQMQQGTRMNGTGNSSSSSYDCSSRKKP 1058
              |.:....|..|.......|:.....|..:|.|.....:        ..|:.|.:....::.|.
 Frog   737 --HPAAAVPSPPSQPASGPIPSSIHITPATIPALSAPPPL--------LSNAPSGAVIPEAKVKE 791

  Fly  1059 RRSTNDSQHSTQSQASLSLPPPSSEPTPPAGAS--YMQKHNNGGLLVTAATPGVAPNSAP----- 1116
            .....|          :|.|..:..|.||...|  .....||..:......||.:|...|
 Frog   792 EAEPMD----------ISRPVSAVPPLPPNSISSPLTVLANNISIPAGELLPGASPRKKPRKQQH 846

  Fly  1117 ------GDANHRNST---------PAVAGNKENANP---------VDFVIRRPR-NCALLNTYKP 1156
                  ||....|||         |..:..::..:|         |.:|..||| ...||..|:.
 Frog   847 VISTEEGDMMETNSTDEERCHAVKPLTSRPEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRN 911

  Fly  1157 THKLANNHFHRYTDVKPREERRATVIDLANQPNVQGKINGWKIYHLRSQMEDL--NESEVFSLGR 1219
            ..|.|.:||.||:||:.:||::.|:.::|||..:..::.|||.:...:|:..|  .|.:||.  |
 Frog   912 PWKAAYHHFQRYSDVRVKEEKKLTLQEVANQKGITCRVQGWKTHLCAAQLLQLIKLEQDVFE--R 974

  Fly  1220 LETMLQDLEKDKEK---HSEIERVTELLKGNIQRSKIITDGINEAQNQLMKIFEHKPHVSNIITR 1281
            | |:||:....|:|   ..::.|:.||::||:||.|::.|.|.|:::.::|:.:||..|..::.:
 Frog   975 L-TVLQEGLIPKKKTATDDDLHRINELIQGNMQRCKLVMDQITESRDCMLKVLDHKDRVLKLLNK 1038

  Fly  1282 C-ASKRNFKKREK 1293
            . ||:|..|.::|
 Frog  1039 SGASRRLTKVKQK 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sap130	NP_729834.1	SAP130_C	<1110..1275	CDD:464973	60/199 (30%)
sap130	XP_012825454.1	PHA03247	<30..544	CDD:223021	152/763 (20%)
		Atrophin-1	416..>820	CDD:460830	111/610 (18%)
		SAP130_C	648..1037	CDD:464973	108/429 (25%)