Protein Alignment Hip1 and SLA2

DIOPT Version :10

• Sequence 1: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_014156.2
• Gene: SLA2 / 855478
• SGDID: S000005187
• Length: 968
• Species: Saccharomyces cerevisiae
• Alignment Length: 1175
• Identity: 248/1175 - (21%)
• Similarity: 472/1175 - (40%)
• Gaps: 279/1175 - (23%)

  Fly    12 LNVSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKFSHLLHKVLR 76
            |..::.||.:..|...|.||.|:.|:.....:.:|..:..:...||.......:|...:|||:::
Yeast     8 LQKALKKACSVEETAPKRKHVRACIVYTWDHQSSKAVFTTLKTLPLANDEVQLFKMLIVLHKIIQ 72

  Fly    77 EGHESAIRHSQSHKKMILEVGKM--WGLLQDDIGCCIQAYSKLLATKLNFHDKNRMF-PGTLNI- 137
            |||.||:..:...:..|..:|::  .|.....:   |:.|.:.|..||:||..:|.| .||...
Yeast    73 EGHPSALAEAIRDRDWIRSLGRVHSGGSSYSKL---IREYVRYLVLKLDFHAHHRGFNNGTFEYE 134

  Fly   138 SFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPIVCLIQ 202
            .:..|....|.|..|  :..:::....:.:......||:|::..|.::     :|:::.::.||.
Yeast   135 EYVSLVSVSDPDEGY--ETILDLMSLQDSLDEFSQIIFASIQSERRNT-----ECKISALIPLIA 192

  Fly   203 DSNALYDLSVRLMFKLH----DGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPEL 263
            :|..:|.....::..:|    |......:...::|:.....:|..||.:...::|...|:|||:|
Yeast   193 ESYGIYKFITSMLRAMHRQLNDAEGDAALQPLKERYELQHARLFEFYADCSSVKYLTTLVTIPKL 257

  Fly   264 PDSSPNFKSQNDF------------------------TSYVPPVVHVPQ-EPDPVVEDLVDTNNH 303
            |..:|:....||.                        .:..||||..|. .|.||.:....|...
Yeast   258 PVDAPDVFLINDVDESKEIKFKKREPSVTPARTPARTPTPTPPVVAEPAISPRPVSQRTTSTPTG 322

  Fly   304 ELEAFSQAQQQLSMLEGIISEKEASIEELSFKLDAMQKNFDALQQSYRHDVQELQQNNTVLSNDL 368
            .|:..........|:........|...:.:.:   ||.:|.|.||
Yeast   323 YLQTMPTGATTGMMIPTATGAANAIFPQATAQ---MQPDFWANQQ-------------------- 364

  Fly   369 VLAREMCATFRMQNDDLEMQLNQNPILLQKAMEEEEKHKLSSEKFNKLKTLYTKIRDEHIQLLRE 433
                   |.|..:.:.||          |:.:::.::.:...|.|.:             ||.:.
Yeast   365 -------AQFANEQNRLE----------QERVQQLQQQQAQQELFQQ-------------QLQKA 399

  Fly   434 QSD-CNKSLNKEKQVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQIEEHKEKIAHLEAVK 497
            |.| .|..|.::.|..:.|:    .|||:.          ||...:||    ::.:::..||:
Yeast   400 QQDMMNMQLQQQNQHQNDLI----ALTNQY----------EKDQALLQ----QYDQRVQQLES-- 444

  Fly   498 NEMKEKFDDVVKQKEIQELDIISTSENLRLNCLKVEELNGNLNDTLEKLSNAESQINAKTEDIEK 562
                          ||..:|  ||:.                    ::|:|.:.|:.|..:.::.
Yeast   445 --------------EITTMD--STAS--------------------KQLANKDEQLTALQDQLDV 473

  Fly   563 MLKAFEAEKALLLTQIEQQSVESKSHSEAQNAQLQEIMDNLEQKDKEFNEVKLQLSSAESQISLK 627
            ..:.:|: .|.|.:|:.|:.:                  ||..:   |.:::|:::||:..|..|
Yeast   474 WERKYES-LAKLYSQLRQEHL------------------NLLPR---FKKLQLKVNSAQESIQKK 516

  Fly   628 ALEIQNNLKAFEAEKSVLLTKIEQLGIEHK---NNSEAQNAQLQLTLNNLEQN----------ES 679
            . ::::.||..:.:.:.|:...::..:|.:   ||:||.:|........:.|:          ||
Yeast   517 E-QLEHKLKQKDLQMAELVKDRDRARLELERSINNAEADSAAATAAAETMTQDKMNPILDAILES 580

  Fly   680 ALQQTQEIVNQLRQENASAGQRNEDLQSKLSLTEVKLTQATQQIDAVTSSYQICSTDLSELRKLV 744
            .:...||.|              .:|.|.||.:. .||..|..:..:.|:.:..:...:....|:
Yeast   581 GINTIQESV--------------YNLDSPLSWSG-PLTPPTFLLSLLESTSENATEFATSFNNLI 630

  Fly   745 IKTVKEICNSKLSGSEQQPLDAVPNIIREMETILNKFNNASAINYVASTEGLQNVMYLGYVFIKL 809
            :       :....|.:.:.:..|.:....|.|::.. :.|.|:
Yeast   631 V-------DGLAHGDQTEVIHCVSDFSTSMATLVTN-SKAYAV---------------------- 665

  Fly   810 YDQCDVIYKTTTAIETGQEIFSKTNLLCTDICQLFQYLLN---NETKEPERQKTI----TDIQTK 867
                     ||...|...:|.:.......:....|:.|::   |:..:.|:...:    .|:|.|
Yeast   666 ---------TTLPQEQSDQILTLVKRCAREAQYFFEDLMSENLNQVGDEEKTDIVINANVDMQEK 721

  Fly   868 LRDIEKLIEKIKASFEQKIDLDKLLEIELREMDAAIDDAASKI--TDLLAKAREKDNQTNLEVNG 930
            |:::...||             .||.|:..:.:...:..:..:  .|.:.|:.|   ...::|..
Yeast   722 LQELSLAIE-------------PLLNIQSVKSNKETNPHSELVATADKIVKSSE---HLRVDVPK 770

  Fly   931 KIVDACTTLMECVKALIQKSRLLQHEIVASQKGNASANEFYRRNSQWSDGLISASKSVAKAANYL 995
            .::.....:::.|.||::.:...|:||..:.  :...|:||.:||:|::|||||:|:||.|.|.|
Yeast   771 PLLSLALMIIDAVVALVKAAIQCQNEIATTT--SIPLNQFYLKNSRWTEGLISAAKAVAGATNVL 833

  Fly   996 VEAANKAIESESGKNF---ELIVAAQEIAACTTQMVIASKVKAERNSQKLTDLTKASRSVTQATG 1057
            :..|:|.|.||..:|.   :.|||::|:||.|.|:|.||:||...:|:....|...|:.||.|..
Yeast   834 ITTASKLITSEDNENTSPEQFIVASKEVAASTIQLVAASRVKTSIHSKAQDKLEHCSKDVTDACR 898

  Fly  1058 TL----VATVKDCNSQLEQQSEIELSKLTPSQIKTMEMEIHVKVLEIEQALQMQRLKLSSFRKEH 1118
            :|    :..::|.:|..:||..::.:  :...:||.|||..|::|::||:|...|.:|...|:..
Yeast   899 SLGNHVMGMIEDDHSTSQQQQPLDFT--SEHTLKTAEMEQQVEILKLEQSLSNARKRLGEIRRHA 961

  Fly  1119 YKNAD 1123
            |.|.|
Yeast   962 YYNQD 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	11..278	CDD:400137	64/297 (22%)
		Mplasa_alph_rch	<312..783	CDD:275316	82/484 (17%)
		EnvC	662..>909	CDD:443969	40/263 (15%)
		ILWEQ	924..1122	CDD:214607	68/204 (33%)
SLA2	NP_014156.2	ANTH	7..269	CDD:400137	62/270 (23%)
		DR0291	420..>546	CDD:441187	35/200 (18%)
		ILWEQ	763..965	CDD:214607	68/205 (33%)