Protein Alignment Hip1 and end4

DIOPT Version :9

• Sequence 1: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_594069.2
• Gene: end4 / 2543336
• PomBaseID: SPAC688.11
• Length: 1102
• Species: Schizosaccharomyces pombe
• Alignment Length: 1253
• Identity: 291/1253 - (23%)
• Similarity: 519/1253 - (41%)
• Gaps: 309/1253 - (24%)

  Fly    12 LNVSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKFSHLLHKVLR 76
            |..||.||.:..|...|.||.||.||.......|:.||..|..|||:.:....:|....:|:||:
pombe    17 LMTSVRKATSIDETAPKRKHVRSCIIFTWDHHTARPFWTAIKVQPLLANEVQTFKALITIHRVLQ 81

  Fly    77 EGHESAIRHSQSHKKMILEVGKMW----------GLLQDDIGCCIQAYSKLLATKLNFHDKNRMF 131
            |||:||:..|||.|..:....:.:          .|::|        |...|..||:||.::..|
pombe    82 EGHKSALVDSQSEKGWLKTCERQYDGESSPKGYSDLIRD--------YVDYLLDKLSFHAQHPEF 138

  Fly   132 PGTLN----ISFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQC 192
            .||..    ||..:    || |.|..::...::.:..:.|...|..:||:.::      :.:.:|
pombe   139 NGTFEYKEYISLRQ----VD-DPNEGYETVYDMMNLQDHIDEFQKQLFSNFKR------SNKNEC 192

  Fly   193 RLAPIVCLIQDSNALYDLSVRLMFKLHDGVPY-DVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKD 256
            |:|.:|.|:|:|..:|.....::..|:..|.. :.:...:.|:.....:|:.||.:...|:|...
pombe   193 RIAALVPLVQESYGIYRFLTSMLRALYSTVDAPETLEPLKHRYKSQHHRLRQFYADCSNLRYLTS 257

  Fly   257 LITIPELPDSSPNFKSQNDF--------------------------TSYVPPV-VHVP------- 287
            ||::|.||...|:.:..::.                          ||..||| ::.|
pombe   258 LISVPRLPHDPPDLEGDDNIPDLPKRPASIAPQPTGASTIAPQPTGTSPSPPVEMNFPDTSDITP 322

  Fly   288 --QEPDPVVEDLVDTNNHELEAFSQAQQQLSMLEGIISEKEASIEELSF---KLDAMQKNFDALQ 347
              .||:|:.:...|....:..|..||.||.:..:..::.::|:.::...   :...|::...|.|
pombe   323 AYSEPEPIQDFWSDPTLDQQLAAQQAAQQAAQQQAELAAQQAAAQQAQLAAQQAAEMERQRMAAQ 387

  Fly   348 QSYRHDVQELQQNNTVLSNDLVLAREMCA--TFRMQND----DLEMQLNQNPILLQKAMEEEEKH 406
            |   |. |.|:......:....:|:|..|  .|:||..    :||.||
pombe   388 Q---HQ-QALEAIQMAQAEQQRIAQEQLAQQQFQMQTQGQLAELEQQL----------------- 431

  Fly   407 KLSSEKFNKLKTLYTKIRDEHIQLLREQSDCNKSLNKEKQVNSQLLLETKELTNEISKIKVNVEE 471
                        |.|:.:.|...:|..|.|.                ..:.|.||:|:..||
pombe   432 ------------LATRGQLEQSNVLLNQYDA----------------RVRTLENELSQAGVN--- 465

  Fly   472 KEKTNLILQKQIEEHKEKIAHLEAVKNEM---KEKFDDVVK---QKEIQELDIISTSENLRLNCL 530
                   ||:||.::.:.|   |::||::   |.|::.:.|   |...:.||::|..:.::|...
pombe   466 -------LQEQIHQNDDLI---ESLKNQILTWKNKYEALAKLYTQLRQEHLDLLSKYKQIQLKAS 520

  Fly   531 KVEELNGNLNDTLEKLSNAESQINAKTEDIEKML-------------------KAFEAEKALLLT 576
            ..:|       .::|....|.::..|..::..|:                   |....|:.|.|.
pombe   521 SAQE-------AIDKKEKMEREMKNKNLELADMILERDRARHELETMHRSQRDKQESTERELRLL 578

  Fly   577 QIEQQSVESKSHSEAQ------NAQLQEIMDNLEQKDKEFNEVKLQLSSAESQISLKALEIQNNL 635
            |.:..|:|....||..      |.::..:.|.|..||:|...:.::|.|.|::.
pombe   579 QEKAASLERNKSSEVSNLLSRYNTEVAHLEDALHSKDRELANLGVELKSTENRY----------- 632

  Fly   636 KAFEAEKSVLLTKIEQLGIEHK--NNSEAQNAQLQLTLNNLEQNESALQQTQEIVNQLRQENASA 698
                  :.:|..|.|:|.|:..  :.|..|.::|||..|:::|                   |..
pombe   633 ------RQLLQEKEEELEIQKAAVDESLLQLSKLQLDRNDIDQ-------------------AMD 672

  Fly   699 GQRNEDLQSKL----SLTEVKLTQATQQIDAVTSSYQICSTDLSELRKLVIKTVKEICNSKLSGS 759
            .|.:|.|:|:|    .:.:..|....|::|  ||.|::                    :|.:...
pombe   673 TQIDELLKSQLEKLDDIVDSVLATGIQRLD--TSLYEL--------------------DSPMHAG 715

  Fly   760 EQQPLDAVPNIIREMETILNKFNNASAI-----NYVAS------TEGLQNVMYLGYVFIKLYDQC 813
            .|.   |.|..|  :.||.|..|||:..     ||.|.      :|.:..|........::.:..
pombe   716 NQY---ATPEFI--LSTIENASNNATDFSTAFNNYFADGPNADHSEVINGVNLFSTAIYEVANNA 775

  Fly   814 DVIYKTTTAIETGQE-------------------IFS----------KTNLLCTDICQLFQYLLN 849
            ..:.: ||..:.|.:                   :||          ||:|:..:..:|.:||
pombe   776 KGLSR-TTGDDQGSDRFVGLSRDLVNMAKRFLSSLFSVNTRKMDVNVKTDLVIGENIELQRYL-- 837

  Fly   850 NETKEPERQKTITDIQTKL--RDIEKLIEKIKASFEQKIDLDKLLEIELREMDAAIDDAASKITD 912
                     :.:|....|.  ::.|..:..:.|..|   ::::|::.:|.|...||..|..::.:
pombe   838 ---------QQLTQYSEKFLNKESENTVGLLNAPGE---NIEELVDNQLAETAQAIQQAILRLQN 890

  Fly   913 LLAKAREKD-NQTNLEVNGKIVDACTTLMECVKALIQKSRLLQHEIVASQKGNASANEFYRRNSQ 976
            :.||.::.. :.:.|:|:..::.|...:.|.:..||:.:...|.||||..:|::|...||:::::
pombe   891 IAAKPKDDSLSPSELQVHDSLLSASIAITEAIARLIKAATASQAEIVAQGRGSSSRGAFYKKHNR 955

  Fly   977 WSDGLISASKSVAKAANYLVEAANKAIESESGKNFE-LIVAAQEIAACTTQMVIASKVKAERNSQ 1040
            |::|||||:|:||:|...|:|.|:..:...|  :|| ||||...::|.|.|:|.||:|||...|:
pombe   956 WTEGLISAAKAVARATTTLIETADGVVNGTS--SFEHLIVACNGVSAATAQLVAASRVKANFASK 1018

  Fly  1041 KLTDLTKASRSVTQATGTLVATVKDCNSQLEQQSEIELSKLTPSQIKTMEMEIHVKVLEIEQALQ 1105
            ....|..|:::||:|...||..|:....:.::....:.|.|...:.:..|:|..|::|::|..|.
pombe  1019 VQDHLEDAAKAVTEACKALVRQVESVALKAKEVQHEDFSSLGVHEYRRKEIEQQVQILKLENDLV 1083

  Fly  1106 MQRLKLSSFRKEHYKNAD 1123
            ..|.:|...||..|..|:
pombe  1084 AARRRLFDMRKTSYHVAE 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	9..281	CDD:284961	78/309 (25%)
		TMPIT	402..>504	CDD:285135	21/104 (20%)
		I_LWEQ	973..1120	CDD:279885	50/147 (34%)
end4	NP_594069.2	ANTH	14..281	CDD:284961	76/282 (27%)
		GAS	468..621	CDD:290562	34/162 (21%)
		ILWEQ	902..1100	CDD:214607	66/199 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I1848
eggNOG	1	0.900	-	-		E1_KOG0980
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I844
OMA	1	1.010	-	-		QHG55957
OrthoFinder	1	1.000	-	-		FOG0002012
OrthoInspector	1	1.000	-	-		oto102046
orthoMCL	1	0.900	-	-		OOG6_102577
Panther	1	1.100	-	-	LDO	PTHR10407
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1344
SonicParanoid	1	1.000	-	-		X1787
TreeFam	1	0.960	-	-
	12	11.950