Protein Alignment Hip1 and hipr-1

DIOPT Version :10

• Sequence 1: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_741253.1
• Gene: hipr-1 / 176224
• WormBaseID: WBGene00022717
• Length: 927
• Species: Caenorhabditis elegans
• Alignment Length: 1152
• Identity: 334/1152 - (28%)
• Similarity: 508/1152 - (44%)
• Gaps: 299/1152 - (25%)

  Fly    15 SVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKFSHLLHKVLREGH 79
            :|.||:...|.|||.||||:||:..||.|.:..||..:.|..|.:.....|||.||:||:||:||
 Worm    18 AVQKAITKNEVPLKPKHARTIIVGTHKEKSSGIFWHTVGRIQLEKHPVLTWKFCHLVHKLLRDGH 82

  Fly    80 ESAIRHSQSHKKMILEVGKMWGLLQ-DDIGCCIQAYSKLLATKLNFHDKNRMFPGTLNISFTELF 143
            ......:..:.....::.:.|..|. ...|.||::|.|||..::.||:|..:.||.|:::.::|
 Worm    83 RKVPEETYRYVNRFTQLSQFWKHLNTSGYGPCIESYCKLLHDRVTFHNKYPVVPGKLDLNDSQL- 146

  Fly   144 IAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPIVCLIQDSNALY 208
            ..::.||:..|::.:::.|.::.::.||..::..|...|.:|:.|||||.|:|::..|.|::..|
 Worm   147 KTLEGDLDNMFEMTIDMLDQMDALLVLQDRVYEMMNSLRWNSLIPQGQCMLSPLIIAILDTSKFY 211

  Fly   209 DLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPELPDSSPNFKSQ 273
            |..|:::||||..||.|.:.|||.||..:|.:.|.||.....|||||.|::||.||..:|||..|
 Worm   212 DYLVKMIFKLHSQVPPDALEGHRSRFRTIFERTKKFYEESSNLQYFKYLVSIPTLPSHAPNFLQQ 276

  Fly   274 NDFTSYVPPVVHVPQEPDPVVEDLVDTNNHELEAFSQA----------------QQQLSML---- 318
            :|..||..|..::..|..   ||....|.|:.|..:.|                ::|:.||
 Worm   277 SDLESYRTPHAYLHSEGS---EDGTSLNGHDGELLNLAEAEPQQASPSSQPDPREEQIVMLSRAV 338

  Fly   319 -------EGIISEKEASIEELSFKLDAMQKNFDALQQSYRHDVQELQQNNTVLSNDLVLAREMCA 376
                   |.:|.|..:.||:...:|..||..||..::....:.:|.|:    |.|:|.| |:
 Worm   339 EDEKFAKERLIQEARSRIEQYENRLLQMQGEFDHAKREADENREEAQR----LKNELAL-RD--- 395

  Fly   377 TFRMQNDDLEMQLNQNPILLQKAMEEEEKHKLSSEKFNKLKTLYTKIRDEHIQLLREQSDCNKSL 441
            ..|.|.||..::            |.|.|...:.|:|||:|.:|.|.|.||:..|.:..|
 Worm   396 ASRTQTDDARVK------------EAELKATAAEERFNKMKGVYEKFRSEHVLALTKLGD----- 443

  Fly   442 NKEKQVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQIEEHKEKIAHLEAVKNEMKEKFDD 506
                                                 :|||:|..:             |.|||
 Worm   444 -------------------------------------IQKQLEASE-------------KSKFD- 457

  Fly   507 VVKQKEIQELDIISTSENLRLNCLKVEELNGNLNDTLEKLSNAESQINAKTEDIEKMLKAFEAEK 571
              |.:||..|:            .||||........|.|   ||....|..|
 Worm   458 --KDEEITALN------------RKVEEAQREAGRALTK---AEGDAGAVDE------------- 492

  Fly   572 ALLLTQIEQQSVESKSHSEAQNAQLQEIMDNLEQKDKEFNEVKLQLSSAE--SQISLKALEIQNN 634
              :.||:.:..:|.:        :|:..:|:|    :|.:..:|..||||  ::|.|..||:..
 Worm   493 --MRTQLVKADIEVE--------ELKRTIDHL----RESHANQLVQSSAEETNKIRLAELEVAK- 542

  Fly   635 LKAFEAEKSVLLTKIEQLGIEHKNNSEAQNAQ--------LQLTLNNLEQNESALQQTQEIVNQL 691
                  |..|.:|::    .:|..:: .|||.        .|..:|||             ||.|
 Worm   543 ------ESGVGITQM----FDHCEDA-LQNATSITYPPHLAQSAMNNL-------------VNIL 583

  Fly   692 RQENASAGQRNEDLQSKLSLTEVKLTQATQQIDAVTSSYQICSTDLSELRKLVIKTVKEICNSKL 756
            ..|     :.:|.|.:|               |.|.:.: :.||.||.
 Worm   584 SNE-----RLDEPLATK---------------DNVFAGH-LLSTTLSA----------------- 610

  Fly   757 SGSEQQPLDAVPNIIREMETILNKFNNASAINYVASTEGLQNVMYLGYVFIKLYDQCDVIYKTTT 821
                                       |::..|.||.|..:.|          .|||..:
 Worm   611 ---------------------------AASAAYTASIESYEGV----------NDQCKKV----- 633

  Fly   822 AIETGQEIFSKTNLLCTDICQLFQYLLNNETKEPERQKTI-TDIQTKLRDIEKLIEKIKASFEQK 885
             :...:..||..:.|                ...::.|.: .||||        :..:..|...:
 Worm   634 -LAAAKVAFSDDSAL----------------SRADKMKLLRQDIQT--------LNSLMISLPLQ 673

  Fly   886 IDLDK-----LLEIELREMDAAIDDAASKITDLLAKAREKDNQTNLEVNGKIVDACTTLMECVKA 945
            .|:||     .||.|:|.||.||..|..:|..:..:|||..:...||||..|:..|..||..:..
 Worm   674 TDIDKDVVGNELEQEMRRMDDAIRRAVQEIEAIQRRARESSDGIRLEVNESILANCQALMSVIMQ 738

  Fly   946 LIQKSRLLQHEIVASQKGNASANEFYRRNSQWSDGLISASKSVAKAANYLVEAANKAIESESGKN 1010
            |:..||.||.||||:.|...|..|||:||.||::||:||:|:|..||..|||:|:..:..: ||.
 Worm   739 LVIASRELQTEIVAAGKAGGSPAEFYKRNHQWTEGLLSAAKAVGVAARVLVESADGVVTGK-GKF 802

  Fly  1011 FELIVAAQEIAACTTQMVIASKVKAERNSQKLTDLTKASRSVTQATGTLVATVKDCNSQLEQQSE 1075
            ..||||||||||.|.|:.::|:|||:::|.||..|:.|:::|.|.|..:||.||:..:.|..:..
 Worm   803 EHLIVAAQEIAASTAQLFVSSRVKADKDSSKLDALSVAAKAVNQNTAQVVAAVKNGQTTLNDEGS 867

  Fly  1076 IELSKLTPSQIKTMEMEIHVKVLEIEQALQMQRLKLSSFRKEHYKNA 1122
            ::.|.|:....|..|||..||:||:||:|..:|.||::.||:||..|
 Worm   868 LDFSYLSLHAAKKEEMESQVKMLELEQSLNQERAKLAALRKQHYHMA 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	11..278	CDD:400137	99/263 (38%)
		Mplasa_alph_rch	<312..783	CDD:275316	101/491 (21%)
		EnvC	662..>909	CDD:443969	50/260 (19%)
		ILWEQ	924..1122	CDD:214607	89/197 (45%)
hipr-1	NP_741253.1	ANTH	14..281	CDD:400137	99/263 (38%)
		Smc	<336..>543	CDD:440809	74/333 (22%)
		XFP	<680..>718	CDD:443157	13/37 (35%)
		ILWEQ	716..914	CDD:214607	89/198 (45%)