Protein Alignment Hip1 and hipr-1

DIOPT Version :9

• Sequence 1: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_741253.1
• Gene: hipr-1 / 176224
• WormBaseID: WBGene00022717
• Length: 927
• Species: Caenorhabditis elegans
• Alignment Length: 1152
• Identity: 334/1152 - (28%)
• Similarity: 508/1152 - (44%)
• Gaps: 299/1152 - (25%)

  Fly    15 SVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKFSHLLHKVLREGH 79
            :|.||:...|.|||.||||:||:..||.|.:..||..:.|..|.:.....|||.||:||:||:||
 Worm    18 AVQKAITKNEVPLKPKHARTIIVGTHKEKSSGIFWHTVGRIQLEKHPVLTWKFCHLVHKLLRDGH 82

  Fly    80 ESAIRHSQSHKKMILEVGKMWGLLQ-DDIGCCIQAYSKLLATKLNFHDKNRMFPGTLNISFTELF 143
            ......:..:.....::.:.|..|. ...|.||::|.|||..::.||:|..:.||.|:::.::|
 Worm    83 RKVPEETYRYVNRFTQLSQFWKHLNTSGYGPCIESYCKLLHDRVTFHNKYPVVPGKLDLNDSQL- 146

  Fly   144 IAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPIVCLIQDSNALY 208
            ..::.||:..|::.:::.|.::.::.||..::..|...|.:|:.|||||.|:|::..|.|::..|
 Worm   147 KTLEGDLDNMFEMTIDMLDQMDALLVLQDRVYEMMNSLRWNSLIPQGQCMLSPLIIAILDTSKFY 211

  Fly   209 DLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPELPDSSPNFKSQ 273
            |..|:::||||..||.|.:.|||.||..:|.:.|.||.....|||||.|::||.||..:|||..|
 Worm   212 DYLVKMIFKLHSQVPPDALEGHRSRFRTIFERTKKFYEESSNLQYFKYLVSIPTLPSHAPNFLQQ 276

  Fly   274 NDFTSYVPPVVHVPQEPDPVVEDLVDTNNHELEAFSQA----------------QQQLSML---- 318
            :|..||..|..::..|..   ||....|.|:.|..:.|                ::|:.||
 Worm   277 SDLESYRTPHAYLHSEGS---EDGTSLNGHDGELLNLAEAEPQQASPSSQPDPREEQIVMLSRAV 338

  Fly   319 -------EGIISEKEASIEELSFKLDAMQKNFDALQQSYRHDVQELQQNNTVLSNDLVLAREMCA 376
                   |.:|.|..:.||:...:|..||..||..::....:.:|.|:    |.|:|.| |:
 Worm   339 EDEKFAKERLIQEARSRIEQYENRLLQMQGEFDHAKREADENREEAQR----LKNELAL-RD--- 395

  Fly   377 TFRMQNDDLEMQLNQNPILLQKAMEEEEKHKLSSEKFNKLKTLYTKIRDEHIQLLREQSDCNKSL 441
            ..|.|.||..::            |.|.|...:.|:|||:|.:|.|.|.||:..|.:..|
 Worm   396 ASRTQTDDARVK------------EAELKATAAEERFNKMKGVYEKFRSEHVLALTKLGD----- 443

  Fly   442 NKEKQVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQIEEHKEKIAHLEAVKNEMKEKFDD 506
                                                 :|||:|..:             |.|||
 Worm   444 -------------------------------------IQKQLEASE-------------KSKFD- 457

  Fly   507 VVKQKEIQELDIISTSENLRLNCLKVEELNGNLNDTLEKLSNAESQINAKTEDIEKMLKAFEAEK 571
              |.:||..|:            .||||........|.|   ||....|..|
 Worm   458 --KDEEITALN------------RKVEEAQREAGRALTK---AEGDAGAVDE------------- 492

  Fly   572 ALLLTQIEQQSVESKSHSEAQNAQLQEIMDNLEQKDKEFNEVKLQLSSAE--SQISLKALEIQNN 634
              :.||:.:..:|.:        :|:..:|:|    :|.:..:|..||||  ::|.|..||:..
 Worm   493 --MRTQLVKADIEVE--------ELKRTIDHL----RESHANQLVQSSAEETNKIRLAELEVAK- 542

  Fly   635 LKAFEAEKSVLLTKIEQLGIEHKNNSEAQNAQ--------LQLTLNNLEQNESALQQTQEIVNQL 691
                  |..|.:|::    .:|..:: .|||.        .|..:|||             ||.|
 Worm   543 ------ESGVGITQM----FDHCEDA-LQNATSITYPPHLAQSAMNNL-------------VNIL 583

  Fly   692 RQENASAGQRNEDLQSKLSLTEVKLTQATQQIDAVTSSYQICSTDLSELRKLVIKTVKEICNSKL 756
            ..|     :.:|.|.:|               |.|.:.: :.||.||.
 Worm   584 SNE-----RLDEPLATK---------------DNVFAGH-LLSTTLSA----------------- 610

  Fly   757 SGSEQQPLDAVPNIIREMETILNKFNNASAINYVASTEGLQNVMYLGYVFIKLYDQCDVIYKTTT 821
                                       |::..|.||.|..:.|          .|||..:
 Worm   611 ---------------------------AASAAYTASIESYEGV----------NDQCKKV----- 633

  Fly   822 AIETGQEIFSKTNLLCTDICQLFQYLLNNETKEPERQKTI-TDIQTKLRDIEKLIEKIKASFEQK 885
             :...:..||..:.|                ...::.|.: .||||        :..:..|...:
 Worm   634 -LAAAKVAFSDDSAL----------------SRADKMKLLRQDIQT--------LNSLMISLPLQ 673

  Fly   886 IDLDK-----LLEIELREMDAAIDDAASKITDLLAKAREKDNQTNLEVNGKIVDACTTLMECVKA 945
            .|:||     .||.|:|.||.||..|..:|..:..:|||..:...||||..|:..|..||..:..
 Worm   674 TDIDKDVVGNELEQEMRRMDDAIRRAVQEIEAIQRRARESSDGIRLEVNESILANCQALMSVIMQ 738

  Fly   946 LIQKSRLLQHEIVASQKGNASANEFYRRNSQWSDGLISASKSVAKAANYLVEAANKAIESESGKN 1010
            |:..||.||.||||:.|...|..|||:||.||::||:||:|:|..||..|||:|:..:..: ||.
 Worm   739 LVIASRELQTEIVAAGKAGGSPAEFYKRNHQWTEGLLSAAKAVGVAARVLVESADGVVTGK-GKF 802

  Fly  1011 FELIVAAQEIAACTTQMVIASKVKAERNSQKLTDLTKASRSVTQATGTLVATVKDCNSQLEQQSE 1075
            ..||||||||||.|.|:.::|:|||:::|.||..|:.|:::|.|.|..:||.||:..:.|..:..
 Worm   803 EHLIVAAQEIAASTAQLFVSSRVKADKDSSKLDALSVAAKAVNQNTAQVVAAVKNGQTTLNDEGS 867

  Fly  1076 IELSKLTPSQIKTMEMEIHVKVLEIEQALQMQRLKLSSFRKEHYKNA 1122
            ::.|.|:....|..|||..||:||:||:|..:|.||::.||:||..|
 Worm   868 LDFSYLSLHAAKKEEMESQVKMLELEQSLNQERAKLAALRKQHYHMA 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	9..281	CDD:284961	101/266 (38%)
		TMPIT	402..>504	CDD:285135	19/101 (19%)
		I_LWEQ	973..1120	CDD:279885	66/146 (45%)
hipr-1	NP_741253.1	ANTH	13..284	CDD:284961	101/266 (38%)
		TPP_enzymes	<680..718	CDD:294952	13/37 (35%)
		ILWEQ	716..914	CDD:214607	89/198 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159606
Domainoid	1	1.000	206	1.000	Domainoid score	I1699
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55957
OrthoDB	1	1.010	-	-		D104219at2759
OrthoFinder	1	1.000	-	-		FOG0002012
OrthoInspector	1	1.000	-	-		otm14291
orthoMCL	1	0.900	-	-		OOG6_102577
Panther	1	1.100	-	-	LDO	PTHR10407
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1344
SonicParanoid	1	1.000	-	-		X1787
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.890