DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip1 and LOC103910581

DIOPT Version :9

Sequence 1:	NP_648597.2	Gene:	Hip1 / 39450	FlyBaseID:	FBgn0036309	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_021335154.1	Gene:	LOC103910581 / 103910581	-ID:	-	Length:	557	Species:	Danio rerio

Alignment Length:	517	Identity:	162/517 - (31%)
Similarity:	266/517 - (51%)	Gaps:	27/517 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AEKE-FYHLNV-SVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKF 67
            |||| |..|.: |:||::...|||:|.|:||.|::..|....|.|||......||..:...:|||
Zfish    23 AEKEQFVKLQLQSISKSITSAEAPIKEKYARKILLGTHTEGGAVTFWSHAISLPLSSNAILSWKF 87

  Fly    68 SHLLHKVLREGHESAIRHSQSHKKMILEVGKMWGLLQDDIGCCIQAYSKLLATKLNFHDKNRMFP 132
            .|::||:||:||.:.:|.|:||...|.::|.:||.|.|..|..:..|||||..|::||.|:...|
Zfish    88 CHMVHKLLRDGHPNMVRDSRSHTAAIRQMGILWGNLHDRYGHIVALYSKLLCIKIDFHLKHPEIP 152

  Fly   133 GTLNISFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPI 197
            ..|..|...|...:..|:|..|.:..|:.||:|..:.||.|:|..|:.:..||.|..|||||||:
Zfish   153 ANLEASEEVLDKVIAIDINKVFDITGEVLDYMEAGLKLQETVFRQMDSHSTSSTTAVGQCRLAPL 217

  Fly   198 VCLIQDSNALYDLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPE 262
            |.|||||..||...|:|:||||..:|.|.:.||||||...|..|..|:...|.:::||.:|.||:
Zfish   218 VLLIQDSGPLYHFLVKLLFKLHSRIPVDALLGHRDRFRDHFNSLTEFFERARGIEFFKTIIQIPD 282

  Fly   263 LPDSSPNFKSQNDFTSYVPPVVHVPQEPDPVVEDLVDTNNHELEAFSQAQ-------QQLSMLEG 320
            ||:..|||........:|.||  |.|....|.:|..:|.    ..||:.|       .|......
Zfish   283 LPNEPPNFLRAASLADHVKPV--VVQNERFVYDDETETQ----ADFSEGQFQPYYGFNQFDYPVD 341

  Fly   321 IISEKEASIEELSFKLDAMQKNFDALQQSYRHDVQELQQNNTVLSNDLVLAREMCATFRMQNDDL 385
            :..::|...:.|..:|:.::...:.::...:..|.:|:.....|.::|...|.......::|:.|
Zfish   342 VPEQRETEADSLRKELEVVKPELELIKVEAQRAVVQLKSQVNKLESELEEQRTHKQMALVENERL 406

  Fly   386 EMQLN----QNPILLQKAMEEEEKHKLSSE-KFNKLKTLYTKIRDEHIQLLREQSDCNKSLNKEK 445
            .||:.    :|...:|..:|:......::: .|.:||..:.::...|..|:|:.::..|..:..:
Zfish   407 RMQVENMRMENTASVQATVEDHSNRAQTAQIHFARLKEKHAELVSRHADLMRKNAEMLKQKSSGQ 471

  Fly   446 QVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQIEEHKEKI----AHLEAVKNEMKEK 503
            |...:||...:::..|:.::.::...|.:..   :.:||..|:::    |.:..|.|.::.|
Zfish   472 QAQEELLAYRQQVAQEMQQLTLDNNSKLEAQ---RAEIERLKQELVSGRAEVSQVHNALQSK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	9..281	CDD:284961	112/272 (41%)
		TMPIT	402..>504	CDD:285135	19/107 (18%)
		I_LWEQ	973..1120	CDD:279885
LOC103910581	XP_021335154.1	VHS_ENTH_ANTH	32..293	CDD:321980	110/260 (42%)
		SMC_N	<344..>539	CDD:330553	34/190 (18%)
		HIP1_clath_bdg	453..538	CDD:318670	16/81 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D86898at33208
OrthoFinder	1	1.000	-	-		FOG0002012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10407
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020