Protein Alignment Hip1 and hip1

DIOPT Version :10

• Sequence 1: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_002933593.2
• Gene: hip1 / 100496371
• XenbaseID: XB-GENE-983522
• Length: 935
• Species: Xenopus tropicalis
• Alignment Length: 1133
• Identity: 335/1133 - (29%)
• Similarity: 531/1133 - (46%)
• Gaps: 242/1133 - (21%)

  Fly    12 LNVSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKFSHLLHKVLR 76
            :.||::||:|..||.:|.||||:.|:..|..|.|:|||..::|.||..:....|||.|:.||:||
 Frog     6 MTVSINKAINTQEAAVKEKHARTCILGTHHEKGAQTFWTAVNRLPLSSNAVLCWKFCHVFHKLLR 70

  Fly    77 EGHESAIRHSQSHKKMILEVGKMWGLLQDDIGCCIQAYSKLLATKLNFHDKNRMFPGTLNISFTE 141
            :||.|.:|.|..:|..::::.:|||.|.:..|.....|.|||..|:.||.||..|||.|.::..:
 Frog    71 DGHPSVLRDSLRYKSELIDMSRMWGHLSEGYGQLCSIYLKLLIIKMEFHTKNPRFPGNLQMTDRQ 135

  Fly   142 LFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPIVCLIQDSNA 206
            |..|.:.|:|..|||.||||||:|..:.|..|:|.|::..|..|:|..|||||:|::.:|.|.:.
 Frog   136 LDEAGENDVNNFFQLTVEIFDYMEWELNLFHTVFKSLDMSRSVSVTAAGQCRLSPLIQVILDCSH 200

  Fly   207 LYDLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPELPDSSPNFK 271
            |||.:|:|:||||..:|.|.:.||||||...|.|||..:.....|||||.|:.||:||::.|||.
 Frog   201 LYDYTVKLLFKLHSCLPTDTLQGHRDRFVEQFQKLKDLFYRSSNLQYFKRLLQIPQLPENPPNFL 265

  Fly   272 SQNDFTSYVPPVVHVPQEPDP-------VVEDLV--DTNNHELEAFSQAQQQLSMLEGIISEKEA 327
            ..:..:.::.|||.:|.|..|       ..||||  ||.:|:
 Frog   266 RASALSEHISPVVLIPSENSPPDSETLIETEDLVGMDTLSHQ----------------------- 307

  Fly   328 SIEELSFKLDAMQKNFDALQQSYRHDVQELQQNNTVLSNDLVLAREMCATFRMQNDDLEMQLNQN 392
            |:.|.:|.        |....|:.:|.......|                 .|:.||.:..:.|
 Frog   308 SLSENTFD--------DIFGSSFSNDPFNFSNQN-----------------GMRRDDKDHLIEQ- 346

  Fly   393 PILLQKAMEEEEKHKLSSEKFNKLKTLYTKIRDEHIQLLREQSDCNKSLNKEKQVNSQLLLETKE 457
             :..:.||..:|.....||....:..|..:|::...:|.           ::|.:..|.:.|.:.
 Frog   347 -LYKEIAMLRDEFGNFKSESHRLVTNLKGRIQELEAELA-----------EQKHLREQAVDENEF 399

  Fly   458 LTNEISKIKVNVEEKEKTNLILQKQIEEHKEKIAHLEAVKNEMKEKFDDVVKQKEIQELDIISTS 522
            |..|:..:|...|:.||.    |:.:.|.:.|....|....::|||:.::|....
 Frog   400 LRTELEDLKRRREDTEKA----QRSLTEIERKSVANEQRYTKLKEKYAELVHSHA---------- 450

  Fly   523 ENLRLNCLKVEELNGNLNDTLEKLSNAESQINAKTE---DIEKMLKAFEAEKALLLTQIEQQSVE 584
                              |.|.|.:....|::...|   |.|:..|..|..     .|...:..:
 Frog   451 ------------------DLLRKNAEVTKQVSVAREALVDTERSKKELEDS-----YQRVNEHTQ 492

  Fly   585 SKSHSEAQNAQLQEIMDNLEQKDKEFNEVKLQLSSAESQISLKALEIQNNLKAFEAEKSVLLTKI 649
            .|:|.     |::| ||.| |...|.|:.::.|..|    |::|.:.:..::..|.::||:
 Frog   493 RKAHE-----QIKE-MDQL-QGALESNKQEIHLLKA----SIEASKQEGQIRIMELKESVI---- 542

  Fly   650 EQLGIEHKNNSEAQNAQLQLTLNNLEQNESALQQT----QEIVNQLRQENASAGQRNEDLQSKLS 710
                                        :..||:.    ||.:.||.:.:.|:|..:.|.....:
 Frog   543 ----------------------------DRVLQEAEFIIQESLRQLDEPHYSSGMISTDFLITRA 579

  Fly   711 LTEVKLTQATQQIDAVTSSYQICSTDLSELRKLVIKTVKEICNSKLSGSEQQPLDAVPNIIREME 775
            |..|   |:|::::....::....:|::.|...:::....|....|.|:.....|.:.:..|...
 Frog   580 LAAV---QSTEKMEEAWKAHMANPSDITLLLPPLVQFAHRISEVILQGALTPTSDRLNDGCRTCG 641

  Fly   776 TILNKFNNASAINYVAS-----TEGLQNVMYLGYVFIKLYDQCDVIYKTTTAIETGQEIFSKTNL 835
            |        .|::|::|     |||..:              |.   :.|.|:
 Frog   642 T--------EALSYLSSLQKNETEGSVH--------------CS---RVTAAL------------ 669

  Fly   836 LCTDICQLFQYLLNNETKEPERQKTITDIQTKLR----DIEKLIEKIKASFEQKIDLDKLLEIEL 896
                                   |.|::|..:||    ||            ::.:|..|:|.|:
 Frog   670 -----------------------KNISEIAQELRPPTLDI------------REEELGDLVEKEM 699

  Fly   897 REMDAAIDDAASKITDLLAKAREKDNQTNLEVNGKIVDACTTLMECVKALIQKSRLLQHEIVASQ 961
            ....||::.||::|.::|.|:|..|....|:||.:|:.:||.||:.::|||..|:.||.|||.|.
 Frog   700 AATAAAVETAATRIEEMLNKSRTDDTGVKLQVNERILGSCTDLMQGIQALILASKDLQKEIVESG 764

  Fly   962 KGNASANEFYRRNSQWSDGLISASKSVAKAANYLVEAANKAIESESGKNFELIVAAQEIAACTTQ 1026
            :|.||..|||.|||:|::|||||||:|...|..:|:||:..::.: ||..:|||.:.||||.|.|
 Frog   765 RGAASQKEFYARNSRWTEGLISASKAVGWGATVMVDAADLVVQGQ-GKFEDLIVCSHEIAASTAQ 828

  Fly  1027 MVIASKVKAERNSQKLTDLTKASRSVTQATGTLVATVKDCNSQLEQQSEIELSKLTPSQIKTMEM 1091
            :|.|||||||:::..|:.|.:||:.|.|....:||:.|...||:|::..::.|.:|.:|||..||
 Frog   829 LVAASKVKAEKDNANLSRLQQASKVVNQNAAGVVASTKCVMSQIEEKDTMDFSSMTLTQIKRKEM 893

  Fly  1092 EIHVKVLEIEQALQMQRLKLSSFRKEHY 1119
            :..|:|||:|..||.:|.||...||:||
 Frog   894 DSQVRVLELENELQKEREKLGELRKKHY 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	11..278	CDD:400137	117/265 (44%)
		Mplasa_alph_rch	<312..783	CDD:275316	84/477 (18%)
		EnvC	662..>909	CDD:443969	45/259 (17%)
		ILWEQ	924..1122	CDD:214607	92/196 (47%)
hip1	XP_002933593.2	ANTH	7..272	CDD:400137	117/264 (44%)
		EnvC	372..>550	CDD:443969	49/268 (18%)
		HIP1_clath_bdg	449..530	CDD:465154	24/124 (19%)
		ILWEQ	726..924	CDD:214607	92/197 (47%)