Protein Alignment Hip1 and hip1r

DIOPT Version :10

• Sequence 1: NP_648597.2
• Gene: Hip1 / 39450
• FlyBaseID: FBgn0036309
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_012810604.1
• Gene: hip1r / 100144673
• XenbaseID: XB-GENE-986342
• Length: 1066
• Species: Xenopus tropicalis
• Alignment Length: 1173
• Identity: 350/1173 - (29%)
• Similarity: 554/1173 - (47%)
• Gaps: 242/1173 - (20%)

  Fly     5 AEKEFYHLN--VSVSKALNGLEAPLKTKHARSIIIMIHKAKEAKTFWMIISRQPLMQSRFTAWKF 67
            ||:|.:..|  :|:|||:|..|||:|.||||.||:..|..|.|.|||......||..|...:|||
 Frog    22 AEREQFDRNQAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKF 86

  Fly    68 SHLLHKVLREGHESAIRHSQSHKKMILEVGKMWGLLQDDIGCCIQAYSKLLATKLNFHDKNRMFP 132
            .|:||||||:||.:.:...|.::..|.|.|::||.:.|..|..:..|:|||..|::||.|:..||
 Frog    87 CHVLHKVLRDGHPNVLSDCQRYRSNIRETGELWGHMHDRYGQLVNIYTKLLLNKISFHVKHPEFP 151

  Fly   133 GTLNISFTELFIAVDRDLNYCFQLCVEIFDYLEDIIALQLTIFSSMEKYRMSSMTPQGQCRLAPI 197
            ..|.::...|..:...|:|..|||.||:|||::..:.|...:|..:......|....|||:|||:
 Frog   152 PGLEVTDDVLEKSAGTDVNNIFQLTVEMFDYMDCELKLAEAVFRQLNSSIAVSQMAAGQCKLAPL 216

  Fly   198 VCLIQDSNALYDLSVRLMFKLHDGVPYDVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLITIPE 262
            :.:|||.:.||..:|:||||||..:|.|.:.|||||||..|..||:|:.....:.|||.||.||.
 Frog   217 IQVIQDCSHLYHYTVKLMFKLHSCLPPDTLQGHRDRFHEQFHSLKNFFKRASDMLYFKRLIQIPR 281

  Fly   263 LPDSSPNFKSQNDFTSYVPPVVHVPQ---EPDPVVEDLVDTNNHELEAFSQAQQQLSMLEGIISE 324
            |||..|||...:....:|.|||.:|.   |.:...|.|::        .|.||.         .|
 Frog   282 LPDGPPNFLRASALAEHVKPVVVIPNETPEDEEPAESLIE--------ISAAQP---------VE 329

  Fly   325 KEASIEELSFKLDAMQKNFDALQQSYRHDVQELQQNNTVLSNDLVLAREMCATFRMQNDDLEMQL 389
            :|..:|:|      .|:.|.|                   .|.|:            .||.::|:
 Frog   330 QEQVVEDL------FQQTFGA-------------------PNGLM------------KDDRDLQI 357

  Fly   390 NQNPILLQKAME----EEEKHKLSSEKF-----NKLKTLYTKIRDEHIQLLREQSDCNKSLNKEK 445
            ..    |||.:|    |.||.||.::|:     .::.||..::.::               .|:|
 Frog   358 EN----LQKEIELLRAELEKIKLEAQKYILQLKGQINTLEAELEEQ---------------RKQK 403

  Fly   446 QVNSQLLLETKELTNEISKIKVNVEEKEKTNLILQKQIEEHKEKIAHLEAVKNEMKEKFDDVVKQ 510
            |   :.|::.::|.:|:.|:|....|.|||..:|.    |.::||...|....::|||.:
 Frog   404 Q---KALVDNEQLRDELEKLKKQKLENEKTQGVLL----EAEKKIQATELRYTKLKEKHN----- 456

  Fly   511 KEIQELDIISTSENLRLNCLKVEELNGNLNDTLEKLSNAESQINAKTEDIEKMLKAFEAEKALLL 575
                  ::|:|...|                 |.|.::...|:....::.|::.:.    |..|.
 Frog   457 ------ELINTHAGL-----------------LRKNADTAKQLTVSQQNQEEVARI----KEELE 494

  Fly   576 TQIEQQSVESKSHSEAQNAQLQEIMDNLEQKDKEFNEVKLQLSSAESQISLKALEIQNNLKAFEA 640
            .|::|...||....|.|:.|.:::...:|.|.||...::..|||.|...|    ::.:.|.:.|.
 Frog   495 FQMDQVKRESDLKLEDQSFQTEQLKSEIEAKKKELLLIQQSLSSTEESKS----QLNSTLMSLEV 555

  Fly   641 E----KSVLLTKIEQLGIEHKNNSEAQNAQLQLTLNNLEQNESALQQTQEIVNQLRQENASAGQR 701
            |    ||:|.||..:|       |.|||               ..:.|:.:.||.:::.||   .
 Frog   556 EKDTLKSLLTTKESEL-------SSAQN---------------LARDTETLFNQEQEKKAS---E 595

  Fly   702 NEDLQSKLSLTEVKLTQATQQI--DAVTSSYQICSTDLSELRKLVIKTVKEI-------CNSK-- 755
            ..||..||:    |.|...|::  ..:...:.|....:.|...::...|.::       |.|.
 Frog   596 IRDLHEKLN----KKTTDEQKLYQKMLEDQFNIIQGTVREAENIIQDAVAKLDDPLHIRCTSSPD 656

  Fly   756 -LSGSEQQPLDAVPNI-------IREM------------------ETILNKFNNASAINYVASTE 794
             |....|..||::|::       |:.|                  :||:    |.||.:::|..:
 Frog   657 YLVCRAQAALDSIPHLENGHAKYIQNMTDASDLVGALAQFAHLTADTIV----NGSATSHLAPPD 717

  Fly   795 GLQNVMYLGYVFIKLYDQCDVIYKTTTAIETGQEIFSKTNLLCTDICQLFQYLLNNETKEPERQK 859
            ...          :|.|.|.         |.|.              |...||.:.:.|...:..
 Frog   718 HAD----------RLNDSCK---------ECGN--------------QSLDYLSSLKNKHSLKNA 749

  Fly   860 TITDIQTKLRDIEKLIEKIK---ASFEQKIDLDKLLEIELREMDAAIDDAASKITDLLAKAREKD 921
            .:.::...|:.|..|.::::   ...:|: :|..:::.|:....|||:.|..:|.:::.:||:..
 Frog   750 DLAEVNRSLKRIFDLGQELRPKSLDIKQE-ELGDMVDKEMASTSAAIEAAVRRIEEMMNQARKDS 813

  Fly   922 NQTNLEVNGKIVDACTTLMECVKALIQKSRLLQHEIVASQKGNASANEFYRRNSQWSDGLISASK 986
            :...||||.:|:::||.||:.::.|:..|..||.|||.|.:|.|:..|||.:||:|::|||||||
 Frog   814 SGVKLEVNERILNSCTDLMKAIRLLVITSTDLQKEIVESGRGAATTQEFYAKNSRWTEGLISASK 878

  Fly   987 SVAKAANYLVEAANKAIESESGKNFELIVAAQEIAACTTQMVIASKVKAERNSQKLTDLTKASRS 1051
            :|...|..|||:|:|.: ...||..||||.:.||||.|.|:|.||||||::||:.|..|.:.||.
 Frog   879 AVGWGATQLVESADKVV-LHKGKYEELIVGSHEIAASTAQLVAASKVKADKNSKNLPKLQQCSRH 942

  Fly  1052 VTQATGTLVATVKDCNSQLEQQSEIELSKLTPSQIKTMEMEIHVKVLEIEQALQMQRLKLSSFRK 1116
            |.:....:||:.|....|:|.:..::.|.::..::|..|||..|||||:|..||.:|::|...|:
 Frog   943 VNEMAANVVASTKSGQEQIEDKDTMDFSGMSLIKLKKEEMESQVKVLELENMLQNERMRLGELRR 1007

  Fly  1117 EHY 1119
            :||
 Frog  1008 QHY 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hip1	NP_648597.2	ANTH	11..278	CDD:400137	114/268 (43%)
		Mplasa_alph_rch	<312..783	CDD:275316	109/520 (21%)
		EnvC	662..>909	CDD:443969	52/286 (18%)
		ILWEQ	924..1122	CDD:214607	88/196 (45%)
hip1r	XP_012810604.1	ANTH	31..297	CDD:400137	113/265 (43%)
		Smc	<351..>637	CDD:440809	87/376 (23%)
		HIP1_clath_bdg	462..560	CDD:465154	26/122 (21%)
		COG4913	<467..813	CDD:443941	86/420 (20%)
		ILWEQ	815..1013	CDD:214607	88/197 (45%)