DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klc and NPHP3

DIOPT Version :10

Sequence 1:NP_524049.1 Gene:Klc / 39445 FlyBaseID:FBgn0010235 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_694972.3 Gene:NPHP3 / 27031 HGNCID:7907 Length:1330 Species:Homo sapiens


Alignment Length:503 Identity:149/503 - (29%)
Similarity:224/503 - (44%) Gaps:85/503 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LQGLEALRVEHVSIMNGIAEVQKDNEKSDMLRKNIENIELGLSEAQVMMALTSHLQNI---EAEK 78
            ||..|.:|:|:         ::.....|...:|.|....|.||:.:|.......|..:   :..|
Human   824 LQAWETVRLEY---------LEGPTVTSSYRQKLINYFTLQLSQDRVTWRSADELPWLFQQQGSK 879

  Fly    79 HKLKTQVRRLH-QENAWLRDELANTQQKFQASEQLVAQLEEEKKHLEFMASVKKYDENQEQDD-- 140
            .||...:..|. .:|.:.|...|.....:    |.|.: ::.....|:..|:|:|::|.|.:|  
Human   880 QKLHDCLLNLFVSQNLYKRGHFAELLSYW----QFVGK-DKSAMATEYFDSLKQYEKNCEGEDNM 939

  Fly   141 ACDKSRTDPVVELFPDEENEDR---------HNMSPTPPSQFANQTS-GYEIPARLRTLHNLVIQ 195
            :|       :.:|:   |...|         ..:.|...|....:|: ..:.|...::||.|...
Human   940 SC-------LADLY---ETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASV 994

  Fly   196 YASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNILALVYRDQNKYKEA------------- 247
            |....::..|..|.|||||..|...|.|||..|..|..||.:|:.||||::|             
Human   995 YVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQK 1059

  Fly   248 -----------ANLLNDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIRE 301
                       |.|...||.:...|||::.|..|.|||.|.|||..:...:.|:...||:||:||
Human  1060 AIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRE 1124

  Fly   302 KVLGKDHPDVAKQLNNLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLK 366
            :|||.||||.|:.|||||.||..:.:||:.|:.|:|||||....|.||.|::|.|..:||..|.|
Human  1125 RVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKK 1189

  Fly   367 QGRYTEAEILYKQVLTRAHEREFG----AIDSKNKPIWQVAEEREEHKFDNRENTPYGEYGGWHK 427
            .|:..:|..|| ::.....::.||    ::.:....:..:..:.::|.    |..|.     :.:
Human  1190 MGKLDKAVPLY-ELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHV----EALPL-----YER 1244

  Fly   428 AAKV--DS-----PTVTTTLKNLGALYRRQGMFEAAETLEDCAMRSKK 468
            |.|:  ||     |.|..|||||..|....|.||.|..|...||..|:
Human  1245 ALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKE 1292

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KlcNP_524049.1 TPR 183..>391 CDD:440225 90/235 (38%)
TPR repeat 187..214 CDD:276809 9/26 (35%)
TPR repeat 228..256 CDD:276809 13/51 (25%)
TPR repeat 270..298 CDD:276809 11/27 (41%)
TPR repeat 311..341 CDD:276809 15/29 (52%)
TPR repeat 354..381 CDD:276809 10/26 (38%)
NPHP3NP_694972.3 PRK03918 <81..>202 CDD:235175
TPR 1 471..504
TPR 2 885..918 6/37 (16%)
TPR 3 920..942 8/28 (29%)
TPR 4 943..976 5/35 (14%)
TPR repeat 943..971 CDD:276809 5/30 (17%)
FxSxx_TPR <951..1289 CDD:468560 115/347 (33%)
TPR 5 985..1018 12/32 (38%)
TPR repeat 985..1013 CDD:276809 9/27 (33%)
TPR repeat 1027..1079 CDD:276809 13/51 (25%)
TPR 6 1027..1060 10/32 (31%)
TPR 7 1093..1126 15/32 (47%)
TPR repeat 1093..1121 CDD:276809 11/27 (41%)
TPR 8 1135..1168 17/32 (53%)
TPR repeat 1135..1163 CDD:276809 14/27 (52%)
TPR repeat 1173..1206 CDD:276809 11/33 (33%)
TPR 9 1177..1210 10/33 (30%)
TPR 10 1219..1252 5/41 (12%)
TPR repeat 1219..1247 CDD:276809 4/36 (11%)
TPR 11 1261..1294 14/32 (44%)
TPR repeat 1261..1289 CDD:276809 12/27 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1296..1330
Blue background indicates that the domain is not in the aligned region.

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