DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp69D and ptprfb

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_009296732.1	Gene:	ptprfb / 799867	ZFINID:	ZDB-GENE-060503-530	Length:	1927	Species:	Danio rerio

Alignment Length:	1821	Identity:	421/1821 - (23%)
Similarity:	690/1821 - (37%)	Gaps:	571/1821 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GKNVSLECASENEA---VAWKLGNQTINKNHTRYKIRTEPLKSNDDGSENNDSQDFIKYKNVLAL 99
            |.:|:|.|.:....   |.|..|...:.|:                       ::....:|||.|
Zfish   261 GGSVNLTCVAVGAPMPYVKWMTGEVELTKD-----------------------EEMPVGRNVLEL 302

  Fly   100 LDVNIKDSGNYTC-----------TAQT------------------------------------- 116
              .||:.|.||||           |||.
Zfish   303 --TNIRQSTNYTCVAISSLGMIEATAQVSVKALPKPPTSLTVTETTATSVTLTWDSGNPEPVSYY 365

  Fly   117 -----GQNHSTEFQ--------------VRPYL----------------PSKVLQ---------S 137
                 .:...|.||              :.||.                ||:.::         |
Zfish   366 IIQYRAKTSDTNFQEVDGVATTRYSIGGLSPYSEYEFRVMAVNNIGRGPPSEPVETRTGEQAPSS 430

  Fly   138 TPDRIK-RKIKQDVMLYCLIEMYPQNETTNRNLK----------------WLKDGSQFEFLDTFS 185
            .|..:: |.:....|   |::..|..| .|..::                |.|..:....|.|.|
Zfish   431 PPLHVQARMLSASTM---LVQWEPPEE-PNGQIRGYRIYYTSDLDAPLSAWQKHNTDDSRLTTIS 491

  Fly   186 SISKLNDTHLNFTLE---FTEV----------YKKENGTYKCTVFDDTGLEITSKEITLFVMEVP 237
            |::    |.:.::|.   ||.|          .|.:.|                         ||
Zfish   492 SLT----TGITYSLRVLGFTSVGDGPPSDVLQVKTQQG-------------------------VP 527

  Fly   238 QVSIDF-AKAVGANKIYLNWTVNDGNDPIQKFFITLQEAGTPTFTYHKDFINGSHT------SYI 295
            .....| |:|....:|.|.| :....|||.|:.:...||         |..|..|.      ||.
Zfish   528 AQPSSFEAEAELDTRILLTW-LWPVQDPIIKYELQYWEA---------DSDNKIHVTFDPAGSYA 582

  Fly   296 LDHFKPNTTYFLRIVGKNSIGNG-------------QPTQYPQGI-------------------- 327
            ::..||:|.|...:..::.:|.|             .|:..||.:
Zfish   583 VEGLKPDTLYKFSLAARSEMGQGVFTHPIEARTAQSAPSAPPQDVHLLSLSSTSIKVSWVAPPAA 647

  Fly   328 --------TTLSYDPI------------------------------------------------- 335
                    .|:||..:
Zfish   648 SRHGAIVRYTVSYQAVNGEDTERHEVPDIGADASSCVLEGLEKWTEYQVWVRAHTDVGPGPESTA 712

  Fly   336 -------FIP-------KVETTGSTASTITIGWNPP-PPDLIDYIQYYELIVS--ESGEV---PK 380
                   .:|       :||...|||..:|  |.|| .......|:.|::|.|  |:||.   |.
Zfish   713 VRIRTNEDVPGAPPRKLEVEALNSTAIRVT--WKPPLSGKQHGQIRGYQVIYSRLENGEPRGHPN 775

  Fly   381 VIEEAIYQQNSRNLPYMFDKLKTATDYE-----------FRVRACSDLTKTCGPWSENVNGTTMD 434
            :::.|        ||....|::.:|:||           :.|...:..||..|..|:....||..
Zfish   776 IMDVA--------LPEAQWKIEESTEYEAVIAGLASETSYSVTVAAYTTKGDGARSKAKVVTTTG 832

  Fly   435 GVATKPTNLSIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYLI---------------------- 477
            .|..|||.:.      :.|.||:..|.|..||...|:::.|.:
Zfish   833 AVPGKPTMII------STTVGNTALIQWQPPKDMVGELMGYRLRYKRLEEENYEIREFSRTDDHH 891

  Fly   478 -------------HL---------------LGNP----------------MSTVDREMWGPK--- 495
                         ||               :|.|                .::..|..|.|.
Zfish   892 TVTDLHKGATYSFHLSARNRAGLGEEYVKDIGTPEDVPSGFPLNLQVVGLTTSTTRLTWEPPALS 956

  Fly   496 ------------IRRIDEPHHKT--------LYESVSPNTNYTVTVSAITRHKKNGEPATGSC-L 539
                        .|.|:...:.|        ..:.:.|:|.|.:.|.|.|  .|.|.|.:.|. .
Zfish   957 ERNGRIIHYIVVYRDINSKQNSTNRTSDTQMTIQGLRPDTTYDIRVQAFT--SKGGGPISPSIQS 1019

  Fly   540 MPVSTPDAIGRTMWSKVNLDSKYVLKLYLPKISERNGPICCYRLYLVRINNDNKELPDPEKLNIA 604
            ..:||..|...:...|..:.:..:|...:|:..:...|      :.:..|..:.|:....|..:.
Zfish  1020 RTMSTSPAFATSFGVKAVMKTSVLLTWEVPENYKSQVP------FKILYNQQSVEVQGNLKRKLI 1078

  Fly   605 TYQEVHSD------NVTRSSAYIAEMISSK------YFRPEIFLGDEKRFSENNDIIRDNDEICR 657
            |..:..:|      :...|:..:.:.:|.:      ..:|.::..|:    .||..:..|   ..
Zfish  1079 TRLQPDTDYSFVLMSRGNSAGGLQQQVSIRTAPDLFKTKPVLYTADQ----TNNGKLTIN---LP 1136

  Fly   658 KCLEGTPFLRKPEIIHIPPQGSLS----NSDS-ELPILSEKDNLIKGANLTEHALKILESKLRDK 717
            |.....| :|...|:.:|...:.|    |.|. ||..|.|..   :||:|.             :
Zfish  1137 KVPTSAP-VRCYYIVVVPVSQTSSRQWINPDEMELDELLESS---EGAHLR-------------R 1184

  Fly   718 RNAVTSDENPILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLE--------------------- 761
            |...|....|.::|....:|...:..|..|        |:||:.
Zfish  1185 RRRHTDTVRPYIAAKLSTLPETFTLGDELD--------YSGFINRPLPNNQHFQCFVMAELKDQY 1241

  Fly   762 -IIVRDRNNALMAYSKYFDIITPATEAEPIQSLNNMDYYLSIGVKAGAVLLGVILVFIVLWVFHH 825
             :...::.....| |.|.|.|....|.:..:|::..:....:|.....||:.:|::.|:|:
Zfish  1242 PVTANEKQRTFSA-SPYSDPIIVQGENQMQRSVDQPEMLWVMGPVLAVVLIIIIVIAILLF---- 1301

  Fly   826 KKTKNE---------------------LQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFD 869
             |:|.|                     ....|.:.:| .|:....|.|.|.........:|
Zfish  1302 -KSKQERKRASPLPKDDHSGGVKDCLLASSSDPVEMR-RLNYQTPGMREHPPISVSELADH---- 1360

  Fly   870 AGPIHRLDLENAYKNRHKDTDYGFLREYEML-PNRFSDRTTKNSDLKENACKNRYPDIKAYDQTR 933
               |.||...:|.:         |.:|||.: |.:  ..|.:||:|:.|..||||.::.|||.:|
Zfish  1361 ---IERLKANDALR---------FSQEYESIDPGQ--QFTWENSNLEVNKPKNRYANVIAYDHSR 1411

  Fly   934 VKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYN 998
            |.|..::|:..:||||:|::.||:::..:|..|||:..|:.|||||||||....|||:|.|||.:
Zfish  1412 VVLTPVDGVPGSDYINSNYIDGYRKQNAYIATQGPLPETLSDFWRMIWEQRASTIVMMTRLEEKS 1476

  Fly   999 KAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTW 1063
            :.||.:|||  :..|:.:|.|.|......:...|..||..:.||.::     ::|::.|:.::.|
Zfish  1477 RVKCDQYWP--IRGTETYGMIQVTMLDAVELATYSVRTFALYKNGSS-----EKREVRQFQFMAW 1534

  Fly  1064 KDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNT 1128
            .|...||:|..|:.|:|::.:......||::|||||||||||..:.:|:::::::.|.:|.||..
Zfish  1535 PDHGVPEYPTPILAFLRRVKACNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGH 1599

  Fly  1129 VCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKPNEGK--CKLEVEF 1191
            |..:|.|||::||:..||||::.|||:..|.|||::....:.:.|:.| .:|:.|:  ..:|:||
Zfish  1600 VTCMRSQRNYMVQTEDQYIFIHEALLEAATCGNTEVPARNLYAHIQKL-TQPSAGETVTAMELEF 1663

  Fly  1192 EKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSE 1256
            ::|..:....|:..| .....|..|||...|:|::..||.|.|:...|.|.|||||.|:||...:
Zfish  1664 KRLANSKAHTSRFIS-ANLPCNKFKNRLVNIMPFESTRVCLQPIRGVEGSDYINASCIDGYRQQK 1727

  Fly  1257 TFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYW-ADDEVQYDHILVKYVHSE 1319
            .:|..|.||..|..|||||:.|.:.|.:||::::.: |..||.:|| |:...:|.:.:|..:...
Zfish  1728 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEY 1792

  Fly  1320 SCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSGCR 1384
            :.|.|..|||.||:.:...:..:.|||:..||  :..||:...|.|:.:.|.   :|..:..|..
Zfish  1793 NMPQYILREFKVTDARDGQSRTIRQFQFTDWP--EQGVPKTGEGFIDFIGQV---HKTKEQFGQD 1852

  Fly  1385 SPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIIN 1449
            .|:|||||.|..|:.:|:.:.|:::.:|.|..||:..|.:.||:||..::.:..||:..:||.:.
Zfish  1853 GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDLFQTVKTLRTQRPAMVQTEDQYQLCYRAALE 1917

  Fly  1450 Y 1450
            |
Zfish  1918 Y 1918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	20/123 (16%)
		Ig	150..221	CDD:143165	18/99 (18%)
		fn3	237..321	CDD:278470	24/103 (23%)
		FN3	339..432	CDD:238020	29/109 (27%)
		FN3	439..535	CDD:238020	31/184 (17%)
		PTPc	892..1155	CDD:214550	104/263 (40%)
		PTPc	920..1155	CDD:238006	94/234 (40%)
		PHA02694	<1121..1206	CDD:177476	30/86 (35%)
		PTPc	1186..1449	CDD:214550	90/264 (34%)
		PTPc	1216..1449	CDD:238006	83/234 (35%)
ptprfb	XP_009296732.1	I-set	35..126	CDD:254352
		Ig2_RPTP_IIa_LAR_like	155..233	CDD:319301
		Ig3_RPTP_IIa_LAR_like	261..329	CDD:143216	22/92 (24%)
		FN3	334..423	CDD:238020	7/88 (8%)
		FN3	430..522	CDD:238020	19/99 (19%)
		FN3	527..615	CDD:238020	24/97 (25%)
		FN3	623..717	CDD:238020	5/93 (5%)
		fn3	725..823	CDD:306538	28/107 (26%)
		FN3	835..916	CDD:238020	14/86 (16%)
		FN3	933..1021	CDD:238020	16/89 (18%)
		PTPc	1397..1626	CDD:238006	94/235 (40%)
		PTPc	1687..1917	CDD:238006	83/234 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810