Protein Alignment Ptp69D and PTPRE

DIOPT Version :10

• Sequence 1: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: XP_047281532.1
• Gene: PTPRE / 5791
• HGNCID: 9669
• Length: 733
• Species: Homo sapiens
• Alignment Length: 685
• Identity: 227/685 - (33%)
• Similarity: 365/685 - (53%)
• Gaps: 83/685 - (12%)

  Fly   809 VLLGVILVFIVL----WVFHHKKTKN---------------ELQGEDTLTLRDSLSRALFGRRNH 854
            :||.::|:.:||    :.|..:|.:.               |.|.:..:.|   |||:
Human    84 LLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVML---LSRS------- 138

  Fly   855 NHSHFITSGNHKGFDAGPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENAC 919
                  .||..|.|   ||....||...:.|..|....|..|:..||:.....|.:.::.:||..
Human   139 ------PSGPKKYF---PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENRE 194

  Fly   920 KNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQH 984
            |||||:|...|.:||.|:.::|:..:|||||:::.||||:.|||.||||.:.|::|||||:|||.
Human   195 KNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQK 259

  Fly   985 LEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKN-----KA 1044
            ...|||||||:|..:.||.:|||::...|  :|:|.|.........||..|...:...     ||
Human   260 SATIVMLTNLKERKEEKCHQYWPDQGCWT--YGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKA 322

  Fly  1045 NVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVA 1109
                   .|.::|.|:.:|.||..|..|.|::||::::.::..:..|||:||||||||||||.:.
Human   323 -------PRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIV 380

  Fly  1110 LDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIE 1174
            :|:::..:..|..|.::..|..:|:||..:||:..||.|:|:|||:...:|:|::.:.::...::
Human   381 IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQ 445

  Fly  1175 SLKRKPNE-GKCKLEVEFEKLLATADEISK-SCSVGENEENNMKNRSQEIIPYDRNRVILTPLPM 1237
            ::...... .|..||.||.||  |...|.| :...|....|..|.|..:|||||.|||||:....
Human   446 TMHGTTTHFDKIGLEEEFRKL--TNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRG 508

  Fly  1238 RENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYW 1301
            :|.:.|||||||:||...:.||..|.||.:|:.||||||.|....|:||::|:.:..: ||.:||
Human   509 QEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYW 573

  Fly  1302 -ADDEVQYDHILVKYVHSESCPYYTRREFYVT----NCKIDDTLKVT-QFQYNGWPTVDGEVPEV 1360
             .:..|.:..|.::..:.......:.|:|.||    ..:.::.::|. ||.::|||.:.  :|..
Human   574 PTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIG--IPAE 636

  Fly  1361 CRGIIELV-------DQAYNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVD 1418
            .:|:|:|:       .|..||           |:|||||.|..|:..|:|:..:::.::.|..:|
Human   637 GKGMIDLIAAVQKQQQQTGNH-----------PITVHCSAGAGRTGTFIALSNILERVKAEGLLD 690

  Fly  1419 ICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDL 1453
            :....:.||.||..::.:..||||.::.:.::.|:
Human   691 VFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDI 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046
		Ig_3	134..216	CDD:464046
		fn3	237..321	CDD:394996
		FN3	<300..>524	CDD:442628
		PTPc	892..1155	CDD:214550	106/267 (40%)
		PTPc	1186..1449	CDD:214550	93/277 (34%)
PTPRE	XP_047281532.1	R-PTPc-E-1	198..426	CDD:350468	96/236 (41%)
		R-PTPc-E-2	513..722	CDD:350470	69/221 (31%)