DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp69D and PTPRE

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_024303860.1	Gene:	PTPRE / 5791	HGNCID:	9669	Length:	731	Species:	Homo sapiens

Alignment Length:	685	Identity:	227/685 - (33%)
Similarity:	365/685 - (53%)	Gaps:	83/685 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   809 VLLGVILVFIVL----WVFHHKKTKN---------------ELQGEDTLTLRDSLSRALFGRRNH 854
            :||.::|:.:||    :.|..:|.:.               |.|.:..:.|   |||:
Human    82 LLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVML---LSRS------- 136

  Fly   855 NHSHFITSGNHKGFDAGPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENAC 919
                  .||..|.|   ||....||...:.|..|....|..|:..||:.....|.:.::.:||..
Human   137 ------PSGPKKYF---PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENRE 192

  Fly   920 KNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQH 984
            |||||:|...|.:||.|:.::|:..:|||||:::.||||:.|||.||||.:.|::|||||:|||.
Human   193 KNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQK 257

  Fly   985 LEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKN-----KA 1044
            ...|||||||:|..:.||.:|||::...|  :|:|.|.........||..|...:...     ||
Human   258 SATIVMLTNLKERKEEKCHQYWPDQGCWT--YGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKA 320

  Fly  1045 NVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVA 1109
                   .|.::|.|:.:|.||..|..|.|::||::::.::..:..|||:||||||||||||.:.
Human   321 -------PRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIV 378

  Fly  1110 LDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIE 1174
            :|:::..:..|..|.::..|..:|:||..:||:..||.|:|:|||:...:|:|::.:.::...::
Human   379 IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQ 443

  Fly  1175 SLKRKPNE-GKCKLEVEFEKLLATADEISK-SCSVGENEENNMKNRSQEIIPYDRNRVILTPLPM 1237
            ::...... .|..||.||.||  |...|.| :...|....|..|.|..:|||||.|||||:....
Human   444 TMHGTTTHFDKIGLEEEFRKL--TNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRG 506

  Fly  1238 RENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-KCPRYW 1301
            :|.:.|||||||:||...:.||..|.||.:|:.||||||.|....|:||::|:.:..: ||.:||
Human   507 QEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYW 571

  Fly  1302 -ADDEVQYDHILVKYVHSESCPYYTRREFYVT----NCKIDDTLKVT-QFQYNGWPTVDGEVPEV 1360
             .:..|.:..|.::..:.......:.|:|.||    ..:.::.::|. ||.::|||.:.  :|..
Human   572 PTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIG--IPAE 634

  Fly  1361 CRGIIELV-------DQAYNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVD 1418
            .:|:|:|:       .|..||           |:|||||.|..|:..|:|:..:::.::.|..:|
Human   635 GKGMIDLIAAVQKQQQQTGNH-----------PITVHCSAGAGRTGTFIALSNILERVKAEGLLD 688

  Fly  1419 ICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDL 1453
            :....:.||.||..::.:..||||.::.:.::.|:
Human   689 VFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDI 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653
		Ig	150..221	CDD:143165
		fn3	237..321	CDD:278470
		FN3	339..432	CDD:238020
		FN3	439..535	CDD:238020
		PTPc	892..1155	CDD:214550	106/267 (40%)
		PTPc	920..1155	CDD:238006	99/239 (41%)
		PHA02694	<1121..1206	CDD:177476	26/86 (30%)
		PTPc	1186..1449	CDD:214550	93/277 (34%)
		PTPc	1216..1449	CDD:238006	82/246 (33%)
PTPRE	XP_024303860.1	PTPc	165..424	CDD:214550	106/267 (40%)
PTPRE	XP_024303860.1	PTPc	484..719	CDD:238006	82/247 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770