DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pmm2 and pmm2

DIOPT Version :9

Sequence 1:	NP_648589.1	Gene:	Pmm2 / 39436	FlyBaseID:	FBgn0036300	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_956378.1	Gene:	pmm2 / 368229	ZFINID:	ZDB-GENE-030722-6	Length:	250	Species:	Danio rerio

Alignment Length:	240	Identity:	136/240 - (56%)
Similarity:	171/240 - (71%)	Gaps:	3/240 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLFDVDGTLTMPRSVVTPEFEEFFYSRVKPRATIGIVGGSDLEKMFEQLNGRKILNEFDFIFPE 76
            |.|||||||||..|...|.:..||. |::|.|..:|:||||||:|:.||| |..:::..|::|.|
Zfish    11 LCLFDVDGTLTAARQKATADMHEFL-SKLKQRVKVGVVGGSDLDKIKEQL-GDDVIDRVDYVFAE 73

  Fly    77 NGLVQIEGGKEVGKQNIIMHLGEETVKRFINFVLRYLSELDVPIKRGTFIEFRNGMMNVCPIGRQ 141
            ||||....||....|||..:|||:.::.||||.|.|||::.:|.||||||||||||:||.||||.
Zfish    74 NGLVAYRFGKLHSVQNIQAYLGEDILQEFINFCLNYLSKIKLPKKRGTFIEFRNGMLNVSPIGRS 138

  Fly   142 CTREERNMFAEYDIEHKVREKMIKDLKQEFADVDLTYSIGGQISFDVFPHGWDKTYCLRHIEAHY 206
            |:::||..|.|.|.:.|:||..:..||:|||...|.:||||||||||||.||||.|||..:|..
Zfish   139 CSQQERIEFFELDKKEKIRETFVSVLKEEFAGKGLAFSIGGQISFDVFPEGWDKRYCLGIVEKD- 202

  Fly   207 KFKEIHFFGDKTEPGGNDYEIYSDPRTISHRVYTPKDTQRILTEI 251
            .::.||||||||.||||||||:.|||||.|.|.:|:|||||..|:
Zfish   203 SYQHIHFFGDKTMPGGNDYEIFVDPRTIGHEVKSPEDTQRICREL 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pmm2	NP_648589.1	HAD-SF-IIB	12..234	CDD:273651	125/221 (57%)
Pmm2	NP_648589.1	PMM	33..254	CDD:281343	124/219 (57%)
pmm2	NP_956378.1	PTZ00174	10..249	CDD:240305	136/240 (57%)
pmm2	NP_956378.1	HAD-SF-IIB	13..232	CDD:273651	126/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578451
Domainoid	1	1.000	250	1.000	Domainoid score	I2078
eggNOG	1	0.900	-	-		E1_COG0561
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H257
Inparanoid	1	1.050	270	1.000	Inparanoid score	I2985
OMA	1	1.010	-	-		QHG53697
OrthoDB	1	1.010	-	-		D1038583at2759
OrthoFinder	1	1.000	-	-		FOG0002294
OrthoInspector	1	1.000	-	-		oto40111
orthoMCL	1	0.900	-	-		OOG6_101634
Panther	1	1.100	-	-	LDO	PTHR10466
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R935
SonicParanoid	1	1.000	-	-		X1518
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800