DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sti and Stk38l

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	NP_001076805.1	Gene:	Stk38l / 691337	RGDID:	1564793	Length:	464	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	150/487 - (30%)
Similarity:	241/487 - (49%)	Gaps:	100/487 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 AKPAGSASGSGIPASTRRSIVPVSTTSAAVAEAICREGLLDAF---CLLYNECDKDTLKKR---- 85
            |..||:.:...:.:.||..:.....|             |:.|   .:|.:| :::|.:|:
  Rat     2 AMTAGATTTFPMSSHTRERVTVAKLT-------------LENFYSNLILQHE-ERETRQKKLEVA 52

  Fly    86 --DRNIAEFVNKFR---PIIEET-----RKLRVNADDFLIKTLIGQGYFGNVHLVVERQTNDIYA 140
              :..:|:...|.|   ...:||     ::.|:..|||....:||:|.||.|.||.::.|..|||
  Rat    53 MEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYA 117

  Fly   141 MKKIKKSVV----TTSQVKEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSRH 201
            ||.::|:.:    ..:.::.||||:...:..|::.:.|:|||..||||:||::||||:::|:.:.
  Rat   118 MKILRKADMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKK 182

  Fly   202 GPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFG-------------- 252
            ....|:..:||::|..:|:..:|::|::||||||:|:|:|..||:||:|||
  Rat   183 DTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFY 247

  Fly   253 --------------------NAAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSR 297
                                .|....::...|:.|.||||||||||:.......||
  Rat   248 RNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKL--------- 303

  Fly   298 IVSCDYWSMGIIGYELICETTPFHEDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRNLIE 362
               ||:||:|:|.||::....||..:...|||.|::|      .||.::||.::.||...::||.
  Rat   304 ---CDWWSLGVIMYEMLIGFPPFCSETPQETYRKVMS------WKETLAFPPEVPVSEKAKDLIL 359

  Fly   363 SLVTNPSKRL---SYERIKNHPFFSEIPWGSIRSQVPPIIP-TVRSDDDTSNFEDGIRHKTRREQ 423
            ...|:...|:   ..|.||.||||..:.||.||.: |..|| .:||.||||||:|      ..|.
  Rat   360 RFCTDSENRIGNGGVEEIKGHPFFEGVDWGHIRER-PAAIPIEIRSIDDTSNFDD------FPES 417

  Fly   424 GVAKKSLTTNMKSNDFSGKDLPFIGYSFVHME 455
            .:.:.  ..|....|:..||..|:.|::...|
  Rat   418 DILQP--VPNTTEPDYKSKDWVFLNYTYKRFE 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	131/382 (34%)
		S_TKc	113..383	CDD:214567	104/310 (34%)
		Smc	487..1222	CDD:224117
		CNH	1503..1774	CDD:279162
Stk38l	NP_001076805.1	STKc_NDR2	87..452	CDD:270776	132/388 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920