Protein Alignment sti and RPS6KA1

DIOPT Version :10

• Sequence 1: NP_001261768.1
• Gene: sti / 39429
• FlyBaseID: FBgn0002466
• Length: 1858
• Species: Drosophila melanogaster
• Sequence 2: NP_001006666.1
• Gene: RPS6KA1 / 6195
• HGNCID: 10430
• Length: 744
• Species: Homo sapiens
• Alignment Length: 718
• Identity: 176/718 - (24%)
• Similarity: 299/718 - (41%)
• Gaps: 185/718 - (25%)

  Fly   107 RVNADDFLIKTLIGQGYFGNVHLV--VER-QTNDIYAMKKIKKSVVTTS---QVKEERDIMSIRN 165
            :.:...|.:..::|||.||.|.||  |.| .:..:||||.:||:.:...   :.|.||||::..|
Human    65 KADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVN 129

  Fly   166 SEWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVH 230
            ..:::.|.||||....|||:::::.||||.:.:|:...|.|:..:||||||.:.|..||.:|.::
Human   130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIY 194

  Fly   231 RDIKPENILIDRFGHIKLADFG-NAAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHD 294
            ||:||||||:|..|||||.||| :..|:|.:....|.  .||.:|:|||:        :::..|.
Human   195 RDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSF--CGTVEYMAPEV--------VNRQGHS 249

  Fly   295 VSRIVSCDYWSMGIIGYELICETTPFHEDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRN 359
                .|.|:||.|::.:|::..:.||...:..||.:.|        ||..:..|..|  |...::
Human   250 ----HSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLI--------LKAKLGMPQFL--STEAQS 300

  Fly   360 LIESLV-TNPSKRL-----SYERIKNHPFFSEIPWGSI--RSQVPPIIPTVRSDDDTSNFEDGIR 416
            |:.:|. .||:.||     ..|.||.|.|:|.|.|..:  |...||..|.|...|||..|:....
Human   301 LLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFT 365

  Fly   417 HKTRREQ-GVAKKS-----------LTTNMKSND----------------FSGKDLPFI-GY--- 449
            .:|.::. |:...:           :.|.:..:|                ..||:|.|. ||
Human   366 SRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVK 430

  Fly   450 ------SFVHMEKSAISATTDE---KLQEKLK-------ELLQKLKTRENEISM----------- 487
                  |:...::....||..|   |:.:|.|       |:|.:.....|.|::
Human   431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVY 495

  Fly   488 LKQDLLRAQQSLRKTDNKSQVVADAKMEIKKLQQII---KEKTMELTTCKTQIKTLQSSAKIDEE 549
            |..:|:|..:.|.|.                |:|..   :|.:..|.|....::.|.|...:..:
Human   496 LVTELMRGGELLDKI----------------LRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRD 544

  Fly   550 M-----------------------WSKKEATITDLLR-------------LNRQKYEE------- 571
            :                       ::|:......||.             |.||.|:|
Human   545 LKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL 609

  Fly   572 -----AKIASEQRYEKQLADKKQELASTLQKLDARELEFNAKFEECKHLSMKLQNYKDMLQQIKE 631
                 ..:|....:....:|..:|:.:.:.         :.||      ::...|:..:.:..|:
Human   610 GILLYTMLAGYTPFANGPSDTPEEILTRIG---------SGKF------TLSGGNWNTVSETAKD 659

  Fly   632 QNLKSETNHEE--QRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSKSTQ 694
              |.|:..|.:  ||....::.:......:.|:..||.:::.:.: :|........:::|||.|.
Human   660 --LVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQL-VKGAMAATYSALNSSKPTP 721

  Fly   695 EAK 697
            :.|
Human   722 QLK 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	Protein Kinases, catalytic domain	111..452	CDD:473864	125/393 (32%)
		SMC_prok_B	481..1254	CDD:274008	43/281 (15%)
		C1	1389..1440	CDD:410341
		CNH	1509..1779	CDD:459938
RPS6KA1	NP_001006666.1	STKc_RSK_N	75..391	CDD:270734	115/339 (34%)
		STKc_RSK1_C	425..715	CDD:271077	49/323 (15%)