DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and RPS6KA1

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	NP_001006666.1	Gene:	RPS6KA1 / 6195	HGNCID:	10430	Length:	744	Species:	Homo sapiens

Alignment Length:	718	Identity:	176/718 - (24%)
Similarity:	299/718 - (41%)	Gaps:	185/718 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 RVNADDFLIKTLIGQGYFGNVHLV--VER-QTNDIYAMKKIKKSVVTTS---QVKEERDIMSIRN 165
            :.:...|.:..::|||.||.|.||  |.| .:..:||||.:||:.:...   :.|.||||::..|
Human    65 KADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVN 129

  Fly   166 SEWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVH 230
            ..:::.|.||||....|||:::::.||||.:.:|:...|.|:..:||||||.:.|..||.:|.::
Human   130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIY 194

  Fly   231 RDIKPENILIDRFGHIKLADFG-NAAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHD 294
            ||:||||||:|..|||||.||| :..|:|.:....|.  .||.:|:|||:        :::..|.
Human   195 RDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSF--CGTVEYMAPEV--------VNRQGHS 249

  Fly   295 VSRIVSCDYWSMGIIGYELICETTPFHEDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRN 359
                .|.|:||.|::.:|::..:.||...:..||.:.|        ||..:..|..|  |...::
Human   250 ----HSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLI--------LKAKLGMPQFL--STEAQS 300

  Fly   360 LIESLV-TNPSKRL-----SYERIKNHPFFSEIPWGSI--RSQVPPIIPTVRSDDDTSNFEDGIR 416
            |:.:|. .||:.||     ..|.||.|.|:|.|.|..:  |...||..|.|...|||..|:....
Human   301 LLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFT 365

  Fly   417 HKTRREQ-GVAKKS-----------LTTNMKSND----------------FSGKDLPFI-GY--- 449
            .:|.::. |:...:           :.|.:..:|                ..||:|.|. ||
Human   366 SRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVK 430

  Fly   450 ------SFVHMEKSAISATTDE---KLQEKLK-------ELLQKLKTRENEISM----------- 487
                  |:...::....||..|   |:.:|.|       |:|.:.....|.|::
Human   431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVY 495

  Fly   488 LKQDLLRAQQSLRKTDNKSQVVADAKMEIKKLQQII---KEKTMELTTCKTQIKTLQSSAKIDEE 549
            |..:|:|..:.|.|.                |:|..   :|.:..|.|....::.|.|...:..:
Human   496 LVTELMRGGELLDKI----------------LRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRD 544

  Fly   550 M-----------------------WSKKEATITDLLR-------------LNRQKYEE------- 571
            :                       ::|:......||.             |.||.|:|
Human   545 LKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL 609

  Fly   572 -----AKIASEQRYEKQLADKKQELASTLQKLDARELEFNAKFEECKHLSMKLQNYKDMLQQIKE 631
                 ..:|....:....:|..:|:.:.:.         :.||      ::...|:..:.:..|:
Human   610 GILLYTMLAGYTPFANGPSDTPEEILTRIG---------SGKF------TLSGGNWNTVSETAKD 659

  Fly   632 QNLKSETNHEE--QRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSKSTQ 694
              |.|:..|.:  ||....::.:......:.|:..||.:::.:.: :|........:::|||.|.
Human   660 --LVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQL-VKGAMAATYSALNSSKPTP 721

  Fly   695 EAK 697
            :.|
Human   722 QLK 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	125/393 (32%)
		S_TKc	113..383	CDD:214567	101/282 (36%)
		Smc	487..1222	CDD:224117	41/275 (15%)
		CNH	1503..1774	CDD:279162
RPS6KA1	NP_001006666.1	S_TKc	71..329	CDD:214567	101/281 (36%)
		STKc_RSK_N	75..391	CDD:270734	115/339 (34%)
		STKc_RSK1_C	425..715	CDD:271077	49/323 (15%)
		Pkinase	427..684	CDD:278497	44/289 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910