Protein Alignment sti and cdc42bpb

DIOPT Version :10

• Sequence 1: NP_001261768.1
• Gene: sti / 39429
• FlyBaseID: FBgn0002466
• Length: 1858
• Species: Drosophila melanogaster
• Sequence 2: XP_021324167.2
• Gene: cdc42bpb / 567039
• ZFINID: ZDB-GENE-030131-3647
• Length: 1789
• Species: Danio rerio
• Alignment Length: 2096
• Identity: 461/2096 - (21%)
• Similarity: 777/2096 - (37%)
• Gaps: 732/2096 - (34%)

  Fly    64 EGLLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVH 128
            |.|||....|||||....| ||::::.:|:...:|.....:::|::.|||.:..:||:|.||.|.
Zfish    28 ETLLDILICLYNECSNSPL-KREKHVTDFLEWVKPFTTTVKEMRLHRDDFEMLKVIGRGAFGEVA 91

  Fly   129 LVVERQTNDIYAMKKIKK----SVVTTSQVKEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYM 189
            :|..:.|..:||||.:.|    ....|:..:|||:::...:.:|:..|.|||||::.|||||:|.
Zfish    92 VVKMKHTERVYAMKILNKWEMLKRAETACFREERNVLVNGDCQWITTLHYAFQDDNYLYLVMDYY 156

  Fly   190 PGGDLLSLMSR-HGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGN 253
            .|||||:|:|: .....||:|:||:||:.:|:|::|:..||||||||:|:|:|..|||:|||||:
Zfish   157 VGGDLLTLLSKFEDRLPEDMAKFYVAEMVLAIHSIHQQRYVHRDIKPDNVLLDMNGHIRLADFGS 221

  Fly   254 AAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHD-VSRI-VSCDYWSMGIIGYELICE 316
            ...:.:||.|.|...|||||||:||:||         :|.| :.:. ..||:||:|:..||::..
Zfish   222 CLKMMQDGTVQSSVAVGTPDYISPEILQ---------AMEDGMGKYGPECDWWSLGVCMYEMLYG 277

  Fly   317 TTPFHEDNVHETYSKILSHCEESHLKELISFPADL-KVSVNYRNLIESLVTNPSKRL---SYERI 377
            .|||:.:::.|||.||::|      :|...||:.: .||.:.::||:.|:.:..:||   ..|..
Zfish   278 ETPFYAESLVETYGKIMNH------EERFQFPSHITDVSEDAKDLIQRLICSRERRLGQHGIEEF 336

  Fly   378 KNHPFFSEIPWGSIRSQVPPIIPTVRSDDDTSNF--EDGIRHKTRREQGVAKKSLTTNMKSNDFS 440
            :.|.|||.|.|.:||:...|.||.|.|..|||||  :|.:         :....:...:....|:
Zfish   337 RKHAFFSGIDWENIRNMEAPYIPDVSSPSDTSNFDVDDDV---------LKNPDIAPPVSHTGFT 392

  Fly   441 GKDLPFIGYSFV---------HMEKSAIS-ATTDEKLQ------EKLKELLQKLKTRENEISMLK 489
            |:.|||:|:::.         .|...|:| ..|.|.||      |..::.::.|:..:.|::...
Zfish   393 GQHLPFVGFTYTTESCFSDGGSMRGVALSDGGTGEDLQDGGMQVEAFEKRIRCLEQEKLELNRKL 457

  Fly   490 QDLLRAQQSLRKTDNKSQVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKK 554
            |:..:|.|||..:...:..:...| |||||.:                       :||
Zfish   458 QESTQAVQSLHGSGRGAGTLGRDK-EIKKLNE-----------------------EID------- 491

  Fly   555 EATITDLLRLNRQKYEEAKIASEQRYEKQLADK---KQELASTLQKLDARELEFNAKFEECKHLS 616
                    ||.:      |:|...|.|.||.:.   :|:..|:..||.|.:.:..|
Zfish   492 --------RLKK------KLADSDRLEHQLEEAVTLRQDFESSSTKLKALDKQVKA--------- 533

  Fly   617 MKLQNYKDMLQQIKE--QNLKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEI 679
            :||:. :|:.:|:.|  ..|||:|...:...|..:|..|:.:::.:::.:.:...:|::.::::
Zfish   534 LKLEK-EDIHKQLVESLDRLKSQTKELKDAHQQRKLAMQEFSEVNERMAELRSQKQRLSRQLRD- 596

  Fly   680 RTELDESISSSKSTQEAKNATERNIEEILRRLNEEIASNNELH-AEKVKLETKLQLKENETQEVR 743
                                .|..:|.::::::   |...::. .||.:.|.:.||     ::.|
Zfish   597 --------------------KEEEMEVVMQKID---AMRQDIRKTEKARKELESQL-----EDAR 633

  Fly   744 AECHRLEREL-QLAECRCQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKG 807
            ||..: ||:| :.:|...:..||.|.|                          |..|:......|
Zfish   634 AEASK-ERKLREHSEVYSKQLESELET--------------------------LKVKQGTGRASG 671

  Fly   808 RADQLQTLVTKLEQMLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVE 872
            ...:.|..:|||:..|                                    ||.....|:.:|.
Zfish   672 LGAETQQELTKLKSEL------------------------------------DKKGLYYEEELVR 700

  Fly   873 RQAARTANLSLWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQRES 937
            |:|:.|..:.  .:.|:|:::                          |.|::
Zfish   701 REASHTTEMK--NLRKELQDS--------------------------EGQQL------------- 724

  Fly   938 RIEELKQELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETELRQKLRQIQSRF 1002
               .|.:||.|.|..:       |||::||.
Zfish   725 ---SLHKELLALKEKL-------EKAKRERQ---------------------------------- 745

  Fly  1003 DGVTLEQKNTIRELQEEREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQLTEVETMLKS 1067
                :|.:..|..|:|:.|:.|.      ::.::.::||....||   ||..|
Zfish   746 ----IEMEEAINALKEQYERERN------LMSEDNRKLTAETDRL---CSFVD------------ 785

  Fly  1068 EQERNKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKRLAEQRAQVLASEIDELRLNLKEQQ 1132
                             ||..:|.||.|..::|.:  .::.:|...||:  :||.:...:.|:.:
Zfish   786 -----------------KLTAQNRQLEDELQELAS--KKESVAHWEAQI--AEIIQWVSDEKDAR 829

  Fly  1133 KKLVAQQDQLVEQTNALFATQ------------ERAELLDGQNANYEAQTADSNREMVSLKEENA 1185
            ..|.|...::.|:..:|.::.            .|::.|| .:|..|.|:|
Zfish   830 GYLQALASKMTEELESLRSSSLGSRTLDPLWKVRRSQKLD-MSARLELQSA-------------- 879

  Fly  1186 RILSELFHKKEEVGNLQAEIRGLESAQANLHAEIDSLQDTLAEKEQFYVQRDIKSNATLAQHKKL 1250
                           |:||||    |:..:|   |.|:...|....|    :.|...|.|::::|
Zfish   880 ---------------LEAEIR----AKQLVH---DELRKVKAANISF----ESKLKDTEAKNREL 918

  Fly  1251 ---IDYLQLKVEDLSAKKKKTLADKLFGSSHTNKENVSPNDVESSILYRALKEELK-REQKMNSL 1311
               ::.::.::|:..::..|.|....|..|..:..|.||           |..||. |:...:|.
Zfish   919 EEQLENMKKEMEESRSRSDKGLKLPDFQDSIFDYFNTSP-----------LAHELTFRDSVSSSS 972

  Fly  1312 LKEQLAQLNGTATLR----SPRK--------SAAVNGDSDAPKQRPVSIAALPRSPQKQQQPLKR 1364
            ....||..:.|:::.    :|:|        |||...|.....|     |..|.:|....||
Zfish   973 ASSLLAFWDETSSVGDVDVAPQKTDIPPSSPSAATEQDEAVKPQ-----ATTPATPSPMYQP--- 1029

  Fly  1365 TTSQVELKTTAEKPTKVTIENQAHHRFELALQESKVDAVNCVVCEKAVVAGS--PFWKCKECKDV 1427
                   ..||.||..        |:..:....|.....:|.    :::.|.  ..:.|:.|..:
Zfish  1030 -------TLTAPKPKA--------HQLSIKTFSSPTQCTHCT----SLMVGQMRQGYACEVCSFI 1075

  Fly  1428 THRKCRSNVQSHCGSTKPTAPSADDLSSIQSVSSLTLDSVDVAGGTTSGGEYIGSLVYSSDGAED 1492
            .|..|:.|....|    |..|.       |:...|   .:||..|.  |..|.|.:
Zfish  1076 CHVSCKDNAPQLC----PIPPE-------QTKRPL---GIDVQRGI--GTAYKGFV--------- 1115

  Fly  1493 QARKEIEVNCAFEVAEQQILLLGCNTGLYAYHL----DSQRLVHISGL-----ESVSCMSICKRL 1548
                .|......:...|:...:.|:..|:.|.:    .:|.:|..|.:     |..|..|:   |
Zfish  1116 ----RIPKPTGVKKGWQRAYAVVCDCKLFLYEVPEGKSTQPVVMASQVLDLRDEEFSVSSV---L 1173

  Fly  1549 AKAIMVGTVGEKLYQCDYRQLESRCQSSSSCHKPV----LETSAIELPFANRTPSEKW------- 1602
            |..::  ....|...|.:|...|..:||.   :||    |..|..|        ..||
Zfish  1174 ASDVI--HANHKDVPCIFRVTSSALKSSI---RPVPLLILAESEAE--------KRKWVGILEGL 1225

  Fly  1603 KLVLISDEAENALDSVAIAATSTRIVILKYDLKLHMFKPVR-ALDTATPVTSIFFTRHSAIVSSD 1666
            :.:|..:..:|.:..|...|..:.:..:|..|...:....| .|.|...:..:..||...:.::|
Zfish  1226 QSILAKNRLKNRVVHVLHEAYDSSLPAIKTTLSAAIVDRERIVLGTEDGLFVVEITRDVIVRAAD 1290

  Fly  1667 --KFYEIDLDNYAAEEFVDL----------------------SDKSMESTAKCQPLT-------- 1699
              |..:|:|  ...|:.|.|                      .|..:..|..||.:|
Zfish  1291 CKKVCQIEL--IPKEKMVALLSGRNRHVHLYPWAALEGAEGGFDTKLTDTRGCQAMTIGNLRPGG 1353

  Fly  1700 ----------------------------------------------------------------- 1699
                                                                             
Zfish  1354 PACLFAGVKRQVFCYEITRAKPHHRKLWEVQAPGVVQWLGIIRERICVGYPSGFALLAMQGESSP 1418

  Fly  1700 -----------------------AVRISRQEYLLCFAEYGVFVDEFGCRSRPYDLNWVYAPTG-- 1739
                                   |:.:...|.||||::.||:||..|.|||..:|.|...|..
Zfish  1419 VSLVSPGDPSLAFLAQQPLDALHAMEVGSNELLLCFSQLGVYVDATGRRSRTQELMWPSTPLACS 1483

  Fly  1740 ------FVYRD--PFLFISH-YQSVQIVRLHR---------------------SFSKEMASG--- 1771
                  .||.|  ..:|..| .:.||.:.|.:                     .||...:.|
Zfish  1484 SNSNCLTVYSDYGVDVFDVHTMEWVQTISLRKIRPLNVEGSLNLLSIEQPHLIYFSNNSSDGCDL 1548

  Fly  1772 --DNASENSES---------------PELQRVYL-------PHYMSTLLANSGDVNLYA------ 1806
              ...|:||:.               ||.:|:..       |...|.|:::..:.|..|
Zfish  1549 AIPETSDNSKKLMVRTRSKRKFLFKVPEEERLQQRREMLRDPEMRSKLISHPTNFNHVAHMGPGD 1613

  Fly  1807 ---VAIDQ------------------RPCNGTQKIYHLDTMQA--FKQKFNISMETL-------S 1841
               |.:|.                  .|....:.:||:..:.|  :.||...|.::|       |
Zfish  1614 GMQVLMDLPLPSETPSPSSSRHHALISPPTNFEHVYHMSPVSAGLYLQKEPSSQQSLLQFSSSSS 1678

  Fly  1842 SVATSVTLGSTVTGNS 1857
            |.:|| :||.:|..:|
Zfish  1679 SPSTS-SLGRSVMPSS 1693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	Protein Kinases, catalytic domain	111..452	CDD:473864	138/353 (39%)
		SMC_prok_B	481..1254	CDD:274008	141/794 (18%)
		C1	1389..1440	CDD:410341	9/52 (17%)
		CNH	1509..1779	CDD:459938	78/447 (17%)
cdc42bpb	XP_021324167.2	None