DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sti and PRKX

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	NP_005035.1	Gene:	PRKX / 5613	HGNCID:	9441	Length:	358	Species:	Homo sapiens

Alignment Length:	314	Identity:	116/314 - (36%)
Similarity:	169/314 - (53%)	Gaps:	40/314 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 DFLIKTLIGQGYFGNVHLVVERQTNDIYAMKKIK-KSVVTTSQ---VKEERDIMSIRNSEWLINL 172
            ||.....:|.|.||.||||.|:.....:|:|.:. ..|:...|   |..|:.::...:..:||.|
Human    48 DFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRL 112

  Fly   173 QYAFQDNDNLYLVMEYMPGGDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPEN 237
            .:.:.|...||::|||:|||:|.|.:...|.|......||.||:..|:..||....|:||:||||
Human   113 FWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPEN 177

  Fly   238 ILIDRFGHIKLADFGNAAAL-DRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSC 301
            ||:||.|||||.|||.|..| ||     :.:..|||:|:|||::|       ||. |  .|.|
Human   178 ILLDRDGHIKLTDFGFAKKLVDR-----TWTLCGTPEYLAPEVIQ-------SKG-H--GRAV-- 225

  Fly   302 DYWSMGIIGYELICETTPFHEDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRNLIES-LV 365
            |:|::||:.:|::....||.:||....|.|||:        ..|.||..|...|  ::||:. ||
Human   226 DWWALGILIFEMLSGFPPFFDDNPFGIYQKILA--------GKIDFPRHLDFHV--KDLIKKLLV 280

  Fly   366 TNPSKRLSYER-----IKNHPFFSEIPWGSI--RSQVPPIIPTVRSDDDTSNFE 412
            .:.::||...:     :|:|.:|..:.|.::  |...|||:|.:..|.||||||
Human   281 VDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFE 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	116/314 (37%)
		S_TKc	113..383	CDD:214567	101/280 (36%)
		Smc	487..1222	CDD:224117
		CNH	1503..1774	CDD:279162
PRKX	NP_005035.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		PTZ00263	39..358	CDD:140289	116/314 (37%)
		STKc_PRKX_like	47..338	CDD:270763	116/314 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910