DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sti and PRKACG

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	NP_002723.2	Gene:	PRKACG / 5568	HGNCID:	9382	Length:	351	Species:	Homo sapiens

Alignment Length:	373	Identity:	125/373 - (33%)
Similarity:	198/373 - (53%)	Gaps:	62/373 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 KDTLKKRDRNIAEFVNKFR---------PIIEETRKLRVNADDFLIKTLIGQGYFGNVHLVVERQ 134
            |||  :::.::.||:.|.|         | .:.|    .::|.|.....:|.|.||.|.||..::
Human     8 KDT--EQEESVNEFLAKARGDFLYRWGNP-AQNT----ASSDQFERLRTLGMGSFGRVMLVRHQE 65

  Fly   135 TNDIYAMKKI-KKSVVTTSQVK---EERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPGGDLL 195
            |...||||.: |:.||...||:   .|:.|:...:..:|:.||::|:||..|||||||:|||::.
Human    66 TGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMF 130

  Fly   196 SLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNAAALDRD 260
            |.:.|.|.|.|..|.||.|::.:|:..||.:..:|||:||||:|||:.|::::.|||.|..:  .
Human   131 SRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRV--K 193

  Fly   261 GHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSCDYWSMGIIGYELICETTPFHEDNV 325
            |...:|  .|||:|:|||::       |||..:.     :.|:|::|::.||:.....||:.|..
Human   194 GRTWTL--CGTPEYLAPEII-------LSKGYNK-----AVDWWALGVLIYEMAVGFPPFYADQP 244

  Fly   326 HETYSKILSHCEESHLKELISFPADLKVSVNYRNLIESLV-TNPSKRLSYER-----IKNHPFFS 384
            .:.|.||:|        ..:.||:  |:|.:.::|:.||: .:.:||....|     ||||.:|:
Human   245 IQIYEKIVS--------GRVRFPS--KLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFA 299

  Fly   385 EIPWGSI--RSQVPPIIPTVRSDDDTSNFED--------GIRHKTRRE 422
            ...|.:|  :....|.||......|.|||:|        .|..|..:|
Human   300 TTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKE 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	116/332 (35%)
		S_TKc	113..383	CDD:214567	101/279 (36%)
		Smc	487..1222	CDD:224117
		CNH	1503..1774	CDD:279162
PRKACG	NP_002723.2	PTZ00426	36..351	CDD:173616	117/342 (34%)
PRKACG	NP_002723.2	STKc_PKA	42..331	CDD:271111	112/314 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910