DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and AgaP_AGAP003005

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_003436351.1	Gene:	AgaP_AGAP003005 / 4577135	VectorBaseID:	AGAP003005	Length:	1422	Species:	Anopheles gambiae

Alignment Length:	1313	Identity:	260/1313 - (19%)
Similarity:	469/1313 - (35%)	Gaps:	363/1313 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 RVNADD------FLIKTLIGQGYFGNVHLVVERQTNDIYAMKKIKKSVV---TTSQVKEERDIMS 162
            ||...|      :.|:..||:|.|..|.|...|.|.:..|:|.|.||.:   ...:|..|.:||.
Mosquito   197 RVKCKDPIRVGFYEIEKTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDPGNLQKVYREVEIMK 261

  Fly   163 IRNSEWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMG 227
            ..:...:|.|....:....:|:|.||...|::...::::|..:|..||....::..|:...|..|
Mosquito   262 RLDHPHVIKLYQVMETQSMIYIVSEYASQGEIFDYIAKYGRLNERAARNKFWQILSAVEYCHNKG 326

  Fly   228 YVHRDIKPENILIDRFGHIKLADFGNAAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSM 292
            .||||:|.||:|:|....||:|||| .:...:.|.:|: :..|:|.|.|||:.:.
Mosquito   327 IVHRDLKAENLLLDSKMDIKIADFG-FSNFYKKGELLA-TWCGSPPYAAPEVFEG---------- 379

  Fly   293 HDVSRIV--SCDYWSMGIIGYELICETTPFHEDNVHETYSKILSHCEESHLKELISFPADLKVSV 355
               .|..  ..|.||:|::.|.|:|...||...::.....::||.          .|.....:|.
Mosquito   380 ---KRYTGPEIDIWSLGVVLYVLVCGALPFDGSSLQSLRDRVLSG----------RFRIPFFMSS 431

  Fly   356 NYRNLI-ESLVTNPSKRLSYERIKNHPFFSEIPWGSIRSQVPPIIPTVRSDDDTSNFEDGIRHKT 419
            :..:|| :.||.:||:|.|.::||.|           |..:..||
Mosquito   432 DCESLIRKMLVLDPSRRFSIDQIKRH-----------RWMMVEII-------------------- 465

  Fly   420 RREQGVAKKSLTTNMKSNDFSGKDLPFIGYSFVHMEKSAISATTDEKLQEKLKELLQKLKTRENE 484
                                   |.|.|....::...|.:||...|. .|::.:::|.|..
Mosquito   466 -----------------------DTPKISSIVINGSVSEVSALETEP-NEQILKIMQNLGI---- 502

  Fly   485 ISMLKQDLLRAQQSLRKTDNKSQVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEE 549
                  |:|:.::|| |..:.....|...:.:::|    |.:|:...........:........|
Mosquito   503 ------DILKTRESL-KLHSYDHYTAFYLLLLERL----KSRTVSHENATAVAGCIGGGKSGMHE 556

  Fly   550 MWSKKEATITDLLRLNRQKYEEAKIASEQRYEK-QLADKKQELASTLQKLDARELEFNAKFEECK 613
            ...::.:.:.:      |...:..|:::.:.:: ..:.|.|:::|.|.                .
Mosquito   557 SQRRRPSNVAE------QAMRKLAISAQHKSDQPSSSPKHQQVSSGLN----------------N 599

  Fly   614 HLSMKLQNYKDMLQQIKE------------QNLKSETNHEEQRRQM------------------- 647
            |.|..|.......||:..            ..|..:|:..||:..:
Mosquito   600 HSSETLHGLLSAAQQVGSGVSPALPAMAPGMMLLRDTSIREQQPVLKDSSYFRGVSYTSSSGFTD 664

  Fly   648 AELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISS------SKSTQEAKNATERNIEE 706
            |.||:  |..||:  ||...|....|:.:      |..|:||      :.:...|.:::.|....
Mosquito   665 ASLYQ--LASLRE--RDCSSTYLTGTVGL------LPSSLSSNVAGTLAAAAAGASSSSARESNS 719

  Fly   707 ILRR----LNEEIASNNELHAEKVKLETKLQLKENETQEVRAECHRL---ERELQLAECRCQL-- 762
            |:.|    |:..|:|:..|.:         .:.:...|:...:|.||   .|.:.:.|.....
Mosquito   720 IVLRESGILSSRISSSRLLSS---------NIDKRILQQSTEDCRRLLQQARPVSMGESNRYTKP 775

  Fly   763 -----AESSLATQVSPYETAPGSLTELNAI-EDQLRADLLAAKESENHQKGRADQLQTLVT---- 817
                 ..|.|....:|...:..|..:.:|: :.|..:|.|.. .|:::....:...:|.:|
Mosquito   776 PSHSPVNSDLHQTAAPQPPSQSSPAQSSAVPQSQRYSDPLNG-FSKDYLTSASSNAETSITVPPF 839

  Fly   818 --KLEQM-----LERFNEQ---------------SLSPTKSHSSRKQEG-------ETVGDMLER 853
              .|..|     |:.:...               :.|.|..:||...||       |.|...:::
Mosquito   840 KDYLNNMQTYSYLQHYEPNLTVASSVASGHTPPPATSITAQYSSSTDEGCETDLGDEDVQQSIDK 904

  Fly   854 QNEKLEDKLAAVREQMIVE--RQAARTANLSL------WKVEKQLEEALSEKKLLARRM---ELT 907
            ..::|....::.....:|.  ...:.:.|||.      :...:.|:..||:...||..:   ..|
Mosquito   905 SIQRLNSFASSSSSSGVVTNIHPKSLSQNLSCDSSRSNFSTFESLDLNLSDCAELAGSLPSCTAT 969

  Fly   908 EDRIKKVQNASDEAQRMLKTSQEETRQRES-------------RIEELKQEL-AAAKRDVLK--- 955
            .:..:.|  |.|||.....||.....|.:.             |...:.|:: ....|.:.:
Mosquito   970 TEAYESV--AKDEATFRAVTSAACINQPQCVYAMSDKVVSSFLRANTVYQDVHNGDHRSITRSPV 1032

  Fly   956 EHRQWEKA-----------------------EQERMK--CKSE-IIEHLANVHRLEQQETELRQK 994
            :.|:..:|                       ..:|:.  ||:: ::|    :|.|:::..:|:.|
Mosquito  1033 DFREGRRASDGLVTQGLVHASDHPLNSPVAFNSQRLNETCKAKGVLE----LHLLQKEAAQLKVK 1093

  Fly   995 -----------LRQIQ-SRF-----DGVTLEQKNTIRELQEEREKSRKANDSCLVLQKELKQLTD 1042
                       :||:| |:|     ||:.|            :..:..|:.|..:........|.
Mosquito  1094 YQANVPQDEINVRQLQHSQFRVNPLDGLLL------------KPLAGSAHGSACLDPASGGTATG 1146

  Fly  1043 NFQR----------LKYACS-ITDSQLTEVETMLKSEQERNKSQKSQLDTLHEKLRERNDQLTDL 1096
            .:.:          :|..|: ....|.......|::||...::..::.|.|.....::..|...|
Mosquito  1147 YYNKVADYVALSLGVKGGCAGSAGGQPEPALGKLEAEQLLLRAGVARSDQLSAAAVQQLQQKPPL 1211

  Fly  1097 RKQLTTVESEKRLAEQRAQVL----ASEIDELRLNLKEQQKKLVAQQDQLVEQTNALFATQERAE 1157
            ::||    .:.||.:|:.|:|    |.|....|..:..|....:|||.|::..    ....|..|
Mosquito  1212 QQQL----MQHRLLQQKRQILQKQGAMEAGLSRRQMLRQHSYKIAQQTQILPP----LPYGEMGE 1268

  Fly  1158 LLDGQNANYEAQTADSNREMVSLKEENARILSEL-------------FHKKEEVGNLQAEIRGLE 1209
            ..||....|  .|..|.||...|:.|..:.|.|.             .|.:::....|.:..||
Mosquito  1269 PGDGPAGGY--PTLQSVRETAILETEPGQTLKEQLELYTHLQAHHSHMHHQQQQHQQQQQQHGL- 1330

  Fly  1210 SAQANLHAEIDSL 1222
            .|.::|.|:..:|
Mosquito  1331 GAGSHLGADRGAL 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	87/352 (25%)
		S_TKc	113..383	CDD:214567	80/275 (29%)
		Smc	487..1222	CDD:224117	163/919 (18%)
		CNH	1503..1774	CDD:279162
AgaP_AGAP003005	XP_003436351.1	STKc_SIK	208..460	CDD:270973	81/287 (28%)
		S_TKc	209..460	CDD:214567	81/286 (28%)
		UBA_SIK	490..533	CDD:270523	11/57 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910